Orobol, an Enzyme-Convertible Product of Genistein, exerts Anti-Obesity Effects by Targeting Casein Kinase 1 Epsilon

[1]  Ximing Qin,et al.  Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε. , 2017, Cellular signalling.

[2]  D. Bechtold,et al.  Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity , 2016, Scientific Reports.

[3]  S. Lim,et al.  Dehydroglyasperin C suppresses TPA‐induced cell transformation through direct inhibition of MKK4 and PI3K , 2016, Molecular carcinogenesis.

[4]  Byung-Gee Kim,et al.  NAD+-specific glutamate dehydrogenase (EC.1.4.1.2) in Streptomyces coelicolor; in vivo characterization and the implication for nutrient-dependent secondary metabolism , 2016, Applied Microbiology and Biotechnology.

[5]  G. Frühbeck,et al.  Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. , 2015, American journal of physiology. Endocrinology and metabolism.

[6]  S. Imai Soybean and Processed Soy Foods Ingredients, and Their Role in Cardiometabolic Risk Prevention. , 2015, Recent patents on food, nutrition & agriculture.

[7]  D. Agyei Bioactive Proteins and Peptides from Soybeans. , 2015, Recent patents on food, nutrition & agriculture.

[8]  S. Kim,et al.  A fermented barley and soybean formula enhances skin hydration , 2015, Journal of clinical biochemistry and nutrition.

[9]  Alan L. Hutchison,et al.  Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. , 2015, Cell host & microbe.

[10]  A. Bode,et al.  A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer. , 2015, Cancer research.

[11]  M. Dastmalchi,et al.  Proteomic insights into synthesis of isoflavonoids in soybean seeds , 2015, Proteomics.

[12]  E. Rosen Two paths to fat , 2015, Nature Cell Biology.

[13]  I. Farooqi,et al.  The Hunger Genes: Pathways to Obesity , 2015, Cell.

[14]  F. Turek,et al.  Chronobiology and obesity: Interactions between circadian rhythms and energy regulation. , 2014, Advances in nutrition.

[15]  E. Nakakura,et al.  Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors , 2013, Oncogene.

[16]  Philippe P Roux,et al.  Casein kinase 1ε promotes cell proliferation by regulating mRNA translation. , 2014, Cancer research.

[17]  A. Bode,et al.  Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma , 2013, Cancer Prevention Research.

[18]  P. Scherer,et al.  Tracking adipogenesis during white adipose tissue development, expansion and regeneration , 2013, Nature Medicine.

[19]  K. Lee,et al.  A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K. , 2013, Molecular nutrition & food research.

[20]  Yung-Hun Yang,et al.  Development of Colorimetric HTS Assay of Cytochrome P450 for ortho‐Specific Hydroxylation, and Engineering of CYP102D1 with Enhanced Catalytic Activity and Regioselectivity , 2013, Chembiochem : a European journal of chemical biology.

[21]  S. Rahbar,et al.  Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. , 2013, International journal of molecular medicine.

[22]  D. Ruggero Translational control in cancer etiology. , 2012, Cold Spring Harbor perspectives in biology.

[23]  V. Preedy Isoflavones : chemistry, analysis, function and effects , 2013 .

[24]  Xin Huang,et al.  Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. , 2012, Journal of medicinal chemistry.

[25]  J. Stephens The Fat Controller: Adipocyte Development , 2012, PLoS biology.

[26]  K. Cheng,et al.  Soyfoods and soybean products: from traditional use to modern applications , 2012, Applied Microbiology and Biotechnology.

[27]  M. Symonds Adipose Tissue Biology , 2012, Springer New York.

[28]  M. Lazar,et al.  Forming functional fat: a growing understanding of adipocyte differentiation , 2011, Nature Reviews Molecular Cell Biology.

[29]  S. Ramón y. Cajal,et al.  The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model. , 2011, International journal of oncology.

[30]  A. Willis,et al.  The biological and therapeutic relevance of mRNA translation in cancer , 2011, Nature Reviews Clinical Oncology.

[31]  Zigang Dong,et al.  Molecular targets of phytochemicals for cancer prevention , 2011, Nature Reviews Cancer.

[32]  D. Cunningham,et al.  Targeted drug therapies and cancer. , 2011, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[33]  J. Yun Possible anti-obesity therapeutics from nature--a review. , 2010, Phytochemistry.

[34]  Myong-Jo Kim,et al.  A new isoflavone glycoside from the stem bark of Sophora japonica , 2010, Archives of pharmacal research.

[35]  A. Levitzki,et al.  Signal transduction therapy of cancer. , 2010, Molecular aspects of medicine.

[36]  Yuanyuan Wu,et al.  Adipose tissue remodeling in pathophysiology of obesity , 2010, Current opinion in clinical nutrition and metabolic care.

[37]  Paolo Sassone-Corsi,et al.  Metabolism and cancer: the circadian clock connection , 2009, Nature Reviews Cancer.

[38]  David M. Sabatini,et al.  An Emerging Role of mTOR in Lipid Biosynthesis , 2009, Current Biology.

[39]  C. Bousquet,et al.  4E‐BP1 is a target of Smad4 essential for TGFβ‐mediated inhibition of cell proliferation , 2009, The EMBO journal.

[40]  M. Harrington,et al.  Casein Kinase‐1‐Epsilon (CK1ε) and Circadian Photic Responses in Hamsters , 2009, Chronobiology international.

[41]  Anne Ørgaard,et al.  The Effects of Soy Isoflavones on Obesity , 2008, Experimental biology and medicine.

[42]  D. Bechtold,et al.  Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins , 2008, Neuron.

[43]  M. Devonald,et al.  Current opinion in clinical nutrition and metabolic care. , 2008, Current opinion in clinical nutrition and metabolic care.

[44]  K. Vafeiadou,et al.  Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway. , 2007, Archives of biochemistry and biophysics.

[45]  M. Bray,et al.  Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte , 2007, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[46]  N. Sonenberg,et al.  Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. , 2007, The Journal of clinical investigation.

[47]  C. Rice-Evans,et al.  The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. , 2006, Free radical biology & medicine.

[48]  A. Greenberg,et al.  Obesity and the role of adipose tissue in inflammation and metabolism. , 2006, The American journal of clinical nutrition.

[49]  K. Klus,et al.  Formation of polyhydroxylated isoflavones from the soybean seed isoflavones daidzein and glycitein by bacteria isolated from tempe , 1995, Archives of Microbiology.

[50]  Andreas Gocht,et al.  The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. , 2005, Cellular signalling.

[51]  Fred W. Turek,et al.  Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice , 2005, Science.

[52]  H. Jha,et al.  Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay , 2005, British Journal of Nutrition.

[53]  N. Sonenberg,et al.  Regulation of cap-dependent translation by eIF4E inhibitory proteins , 2005, Nature.

[54]  A. Sorisky,et al.  Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1 , 2004, International Journal of Obesity.

[55]  L. Fajas Adipogenesis: a cross-talk between cell proliferation and cell differentiation , 2003, Annals of medicine.

[56]  E. Jéquier Pathways to obesity , 2002, International Journal of Obesity.

[57]  B. Spiegelman,et al.  Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1 , 2001, Nature Medicine.

[58]  S. Gygi,et al.  Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. , 1999, Genes & development.