Problems with enuresis management—A personal view

Much has happened since the end of the era when enuresis was blamed on the parents or the children themselves. Still, there are large gaps in our knowledge and large parts of modern enuresis management guidelines are (still) not based on firm evidence. In this review I will question the following commonly made assumptions regarding enuresis evaluation and treatment: • It is important to subdivide enuresis according to the presence of daytime symptoms • Voiding charts are crucial in the primary evaluation of the enuretic child • All children with enuresis need to be screened for behavioral or psychiatric issues • Concomittant daytime incontinence needs to be successfully treated before addressing the enuresis • Concomittant constipation needs to be successfully treated before addressing the enuresis • Urotherapy is a first-line treatment against enuresis In this review I will argue that much of what we do with these children is based more on experience and well-meant but poorly supported assumptions than on evidence. Some advice and therapies are probably ineffective whereas for other treatments we lack reliable predictors of treatment response. More research is obviously needed, but awaiting new results enuresis management could be substantially simplified.

[1]  T. Nevéus,et al.  Constipation treatment does not make enuretic children dry at night , 2022, Journal of Pediatric Urology.

[2]  J. Walle,et al.  Impact of New vs. Old International Children’s Continence Society Standardization on the Classification of Treatment Naïve Enuresis Children at Screening: The Value of Voiding Diaries and Questionnaires , 2022, Frontiers in Pediatrics.

[3]  T. Nevéus,et al.  Daytime urotherapy in nocturnal enuresis: a randomised, controlled trial , 2022, Archives of Disease in Childhood.

[4]  K. Kaneko,et al.  Desmopressin response in nocturnal enuresis without nocturnal polyuria in Japanese children , 2021, International journal of urology : official journal of the Japanese Urological Association.

[5]  A. von Gontard,et al.  Definitions, indications and practice of urotherapy in children and adolescents: - A standardization document of the International Children's Continence Society (ICCS). , 2020, Journal of pediatric urology.

[6]  R. Kirschner-Hermanns,et al.  Overactive bladder syndrome – focus onto detrusor overactivity , 2020, Scandinavian journal of urology.

[7]  M. Rodríguez-Ruiz,et al.  [Influence of constipation on enuresis]. , 2020, Anales de pediatria.

[8]  Sang Don Lee,et al.  Evaluation of Functional Bladder Capacity in Children with Nocturnal Enuresis According to Type and Treatment Outcome , 2020, Research and reports in urology.

[9]  Mu-Hong Chen,et al.  Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study , 2020, Clinical epidemiology.

[10]  A. Kawauchi,et al.  Management and treatment of nocturnal enuresis-an updated standardization document from the International Children's Continence Society. , 2020, Journal of pediatric urology.

[11]  C. Hsieh,et al.  Association between constipation and childhood nocturnal enuresis in Taiwan: a population-based matched case-control study , 2020, BMC Pediatrics.

[12]  R. Stein,et al.  Practical recommendations of the EAU‐ESPU guidelines committee for monosymptomatic enuresis—Bedwetting , 2019, Neurourology and Urodynamics.

[13]  S. Guarino,et al.  'Frequently recurring' nocturnal polyuria is predictive of response to desmopressin in monosymptomatic nocturnal enuresis in childhood. , 2019, Journal of Pediatric Urology.

[14]  T. Nevéus The amount of urine voided in bed by children with enuresis. , 2019, Journal of pediatric urology.

[15]  A. Teixeira-Pinto,et al.  Prevalence, patient and consultation characteristics of enuresis in Australian paediatric practice , 2018, Journal of Paediatrics and Child Health.

[16]  C. Wolfe‐Christensen,et al.  Children with nocturnal enuresis and attention deficit hyperactivity disorder: A separate entity? , 2017, Journal of pediatric urology.

[17]  M. Tkaczyk,et al.  Evaluation of the effect of 3-month bladder basic advice in children with monosymptomatic nocturnal enuresis. , 2017, Journal of pediatric urology.

[18]  S. Rittig,et al.  Enuresis: practical guidelines for primary care , 2017, The British journal of general practice : the journal of the Royal College of General Practitioners.

[19]  T. Nevéus Pathogenesis of enuresis: Towards a new understanding , 2017, International journal of urology : official journal of the Japanese Urological Association.

[20]  S. Bauer,et al.  Treatment of daytime urinary incontinence: A standardization document from the International Children's Continence Society , 2017, Neurourology and urodynamics.

[21]  J. M. Bastos Netto,et al.  Constipation and Lower Urinary Tract Dysfunction in Children and Adolescents: A Population-Based Study , 2016, Front. Pediatr..

[22]  Kiyoto Kasai,et al.  Enuresis and Hyperactivity-Inattention in Early Adolescence: Findings from a Population-Based Survey in Tokyo (Tokyo Early Adolescence Survey) , 2016, PloS one.

[23]  M. A. Karagoz,et al.  Prevalence of nocturnal enuresis and its influence on quality of life in school-aged children. , 2016, Journal of pediatric urology.

[24]  M. Benninga,et al.  Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. , 2016, Gastroenterology.

[25]  O. Kurt,et al.  Nocturnal enuresis with spina bifida occulta: Does it interfere behavioral management success? , 2015, International Urology and Nephrology.

[26]  A. Sarkadi,et al.  No effect of basic bladder advice in enuresis: A randomized controlled trial. , 2015, Journal of pediatric urology.

[27]  A. Gontard,et al.  Comorbidity of ADHD and incontinence in children , 2015, European Child & Adolescent Psychiatry.

[28]  E. Erdem Faculty Opinions recommendation of The standardization of terminology of lower urinary tract function in children and adolescents: update report from the Standardization Committee of the International Children's Continence Society. , 2014 .

[29]  N. Rittig,et al.  Outcome of a standardized approach to childhood urinary symptoms—long‐term follow‐up of 720 patients , 2014, Neurourology and urodynamics.

[30]  Jun-Mo Kim,et al.  Evaluation of nocturnal bladder capacity and nocturnal urine volume in nocturnal enuresis. , 2014, Journal of pediatric urology.

[31]  S. Bauer,et al.  The standardization of terminology of lower urinary tract function in children and adolescents: update report from the Standardization Committee of the International Children's Continence Society. , 2006, The Journal of urology.

[32]  U. Barroso,et al.  Constipation in children with isolated overactive bladders. , 2013, Journal of pediatric urology.

[33]  S. Bauer,et al.  Management of functional constipation in children with lower urinary tract symptoms: report from the Standardization Committee of the International Children's Continence Society. , 2013, The Journal of urology.

[34]  H. Suh,et al.  A Nationwide Epidemiological Study of Nocturnal Enuresis in Korean Adolescents and Adults: Population Based Cross Sectional Study , 2013, Journal of Korean medical science.

[35]  H. Hashim,et al.  Bladder wall thickness and urodynamic correlation in children with primary nocturnal enuresis. , 2013, Journal of pediatric urology.

[36]  M. Dijkgraaf,et al.  Functional defecation disorders in children with lower urinary tract symptoms. , 2013, The Journal of urology.

[37]  S. Rittig,et al.  Bladder and bowel dysfunction and the resolution of urinary incontinence with successful management of bowel symptoms in children , 2013, Acta paediatrica.

[38]  A. von Gontard,et al.  Evaluation and treatment of nonmonosymptomatic nocturnal enuresis: a standardization document from the International Children's Continence Society. , 2013, Journal of pediatric urology.

[39]  M. Hiradfar,et al.  Monosymptomatic and non-monosymptomatic nocturnal enuresis: a clinical evaluation. , 2012, Archives of Iranian medicine.

[40]  Ronak A Gor,et al.  A retrospective observational study of enuresis, daytime voiding symptoms, and response to medical therapy in children with attention deficit hyperactivity disorder and autism spectrum disorder. , 2012, Journal of pediatric urology.

[41]  K. Schweitzer,et al.  Associations between subjective overactive bladder symptoms and objective parameters on bladder diary and filling cystometry , 2012, International Urogynecology Journal.

[42]  Serdar Tekgul,et al.  Practical consensus guidelines for the management of enuresis , 2012, European Journal of Pediatrics.

[43]  J. Kim,et al.  The Prevalence and Therapeutic Effect of Constipation in Pediatric Overactive Bladder , 2011, International neurourology journal.

[44]  J. Heron,et al.  Family history of nocturnal enuresis and urinary incontinence: results from a large epidemiological study. , 2011, The Journal of urology.

[45]  V. Khullar,et al.  Rectal distension: The effect on bladder function , 2011, Neurourology and urodynamics.

[46]  I. Franco The Central Nervous System and its Role in Bowel and Bladder Control , 2011, Current urology reports.

[47]  Kwan Park,et al.  The efficacy of enuresis alarm treatment in pharmacotherapy-resistant nocturnal enuresis. , 2011, Urology.

[48]  C. Di Lorenzo,et al.  Effect of rectal distention on lower urinary tract function in children. , 2010, The Journal of urology.

[49]  J. Djurhuus,et al.  Timer watch assisted urotherapy in children: a randomized controlled trial. , 2010, The Journal of urology.

[50]  P. Eggert,et al.  Evaluation of and treatment for monosymptomatic enuresis: a standardization document from the International Children's Continence Society. , 2010, The Journal of urology.

[51]  A. Bordallo,et al.  Lower urinary tract symptoms in enuretic and nonenuretic children. , 2009, The Journal of urology.

[52]  A. Szabo,et al.  Objective differences between overactive bladder patients with and without urodynamically proven detrusor overactivity , 2009, International Urogynecology Journal.

[53]  M. Michel,et al.  Basic mechanisms of urgency: preclinical and clinical evidence. , 2009, European urology.

[54]  H. Roeyers,et al.  Adherence in children with nocturnal enuresis. , 2009, Journal of pediatric urology.

[55]  J. Djurhuus,et al.  The effect of desmopressin on renal water and solute handling in desmopressin resistant monosymptomatic nocturnal enuresis. , 2008, The Journal of urology.

[56]  R. Baker,et al.  A POPULATION-BASED CROSS-SECTIONAL STUDY , 2008 .

[57]  I. Franco Pediatric Overactive Bladder Syndrome , 2007, Paediatric drugs.

[58]  V. Loening-Baucke Prevalence rates for constipation and faecal and urinary incontinence , 2006, Archives of Disease in Childhood.

[59]  S. Bauer,et al.  The standardization of terminology of lower urinary tract function in children and adolescents: Report from the standardization committee of the International Children's Continence Society (ICCS) , 2006, The Journal of urology.

[60]  Katsumi Inoue,et al.  Nocturnal enuresis and overactive bladder in children: An epidemiological study , 2006, International journal of urology : official journal of the Japanese Urological Association.

[61]  Vanessa Hill,et al.  Prevalence of diurnal voiding symptoms and difficult arousal from sleep in children with nocturnal enuresis. , 2004, The Journal of urology.

[62]  A. Hjern,et al.  Urinary and faecal incontinence: a population‐based study , 2004, Acta paediatrica.

[63]  A. J. van der Heijden,et al.  Alarm treatment is successful in children with day‐ and night‐time wetting , 2004, Scandinavian journal of urology and nephrology.

[64]  M. Pennesi,et al.  Behavioral therapy for primary nocturnal enuresis. , 2004, The Journal of urology.

[65]  C. Wong,et al.  Reduction in nocturnal functional bladder capacity is a common factor in the pathogenesis of refractory nocturnal enuresis , 2002, BJU international.

[66]  Magnus Fall,et al.  The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. , 2003, Urology.

[67]  J. Wyndaele,et al.  Voiding Habits and Wetting in a Population of 4332 Belgian Schoolchildren Aged Between 10 and 14 Years , 2002, Scandinavian journal of urology and nephrology.

[68]  T. Nevéus Oxybutynin, desmopressin and enuresis. , 2001, The Journal of urology.

[69]  J. Djurhuus,et al.  Intra-individual variability in nighttime urine production and functional bladder capacity estimated by home recordings in patients with nocturnal enuresis. , 2001, The Journal of urology.

[70]  T. Jørgensen,et al.  Changes in nocturnal bladder capacity during treatment with the bell and pad for monosymptomatic nocturnal enuresis. , 1998, The Journal of urology.

[71]  A. Hellström,et al.  Standardization and definitions in lower urinary tract dysfunction in children. International Children's Continence Society. , 1998, British journal of urology.

[72]  P. Austin,et al.  Daytime Functional Bladder Capacity as a Predictor of Response to Desmopressin in Monosymptomatic Nocturnal Enuresis , 1998, European Urology.

[73]  A. Hansen,et al.  Alarm treatment: influence on functional bladder capacity. , 1997, Scandinavian Journal of Urology and Nephrology, Supplementum.

[74]  E. Bergström,et al.  Self-esteem before and after treatment in children with nocturnal enuresis and urinary incontinence. , 1997, Scandinavian journal of urology and nephrology. Supplementum.

[75]  R. Shepherd,et al.  The epidemiology of childhood enuresis in Australia. , 1996, British journal of urology.

[76]  H. G. Rushton,et al.  The influence of small functional bladder capacity and other predictors on the response to desmopressin in the management of monosymptomatic nocturnal enuresis. , 1996, The Journal of urology.

[77]  S. Rittig,et al.  Polyuric and non-polyuric bedwetting--pathogenic differences in nocturnal enuresis. , 1995, Scandinavian journal of urology and nephrology. Supplementum.

[78]  S. Leeder,et al.  A population based study , 1993, The Medical journal of Australia.

[79]  T. Esen,et al.  Rationale of urodynamic assessment in adult enuresis. , 1992, European Urology.

[80]  E. B. Pedersen,et al.  Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis. , 1989, The American journal of physiology.

[81]  X. Triviño,et al.  [Unstable bladder in childhood]. , 1985, Revista chilena de pediatria.

[82]  I. Berg,et al.  Response of bedwetting to the enuresis alarm. Influence of psychiatric disturbance and maximum functional bladder capacity. , 1982, Archives of disease in childhood.

[83]  M. Oermann,et al.  [Clinical evaluation]. , 1981, Ugeskrift for laeger.

[84]  W. Silverman "PRECLINICAL" AND "CLINICAL" EVIDENCE , 1968, Pediatrics.

[85]  H. Sutton AN EPIDEMIOLOGICAL STUDY , 1937 .