The impact of rTMS over the dorsolateral prefrontal cortex on cognitive processing

The purpose of the present study was to use event-related potentials (ERP) to clarify the effect of magnetic stimulation on cognitive processing. A figure eight-shaped flat repetitive transcranial magnetic stimulation (rTMS) coil was used to stimulate either the region over the left or the right dorsolateral prefrontal cortex, which is considered to be the origin of the P300 component. Stimulus frequencies were 1.00, 0.75 and 0.50 Hz rTMS. The strength of the magnetic stimulation was set at 80% of the motor threshold for each participant. The auditory oddball task was used to elicit P300s before and shortly after rTMS, and comprised a sequence of sounds containing standard (1 kHz pure tone, 80% of trials) and deviant (2 kHz pure tone, 20% of trials) stimuli. We found that a 1.00 Hz rTMS pulse train over the left dorsolateral prefrontal cortex increased P300 latencies by 8.50 ms at Fz, 12.85 ms at Cz, and 11.25 ms at Pz. In contrast, neither 0.75 and 0.50 Hz rTMS pulse trains over the left dorsolateral prefrontal cortex nor 1.00, 0.75 and 0.50 Hz rTMS pulse trains over the right dorsolateral prefrontal cortex altered P300 latencies. These results indicate that rTMS frequency affects cognitive processing. Thus, we suggest that the effects of rTMS vary according to the activity of excitatory and inhibitory neurons in the cerebral cortex.

[1]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[2]  R. Johnson.  Developmental evidence for modality-dependent P300 generators: a normative study. , 1989, Psychophysiology.

[3]  B. Steinhoff,et al.  Effects of antiepileptic drugs on motor cortex excitability in humans: A transcranial magnetic stimulation study , 1996, Annals of neurology.

[4]  T Takayanagi,et al.  The site of action of magnetic stimulation of human motor cortex in a patient with motor neuron disease. , 1993, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[5]  Barry Fowler,et al.  Biological determinants of P300: the effects of a barbiturate on latency and amplitude , 1997, Biological Psychology.

[6]  H Scheich,et al.  Rapid-rate transcranial magnetic stimulation in auditory cortex induces LTP and LTD and impairs discrimination learning of frequency-modulated tones. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[7]  J. Donoghue,et al.  Long-term potentiation and long-term depression of horizontal connections in rat motor cortex. , 1996, Acta neurobiologiae experimentalis.

[8]  Y Mano,et al.  Cortical reorganization in training. , 2003, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[9]  J. Rothwell,et al.  Facilitation of muscle evoked responses after repetitive cortical stimulation in man , 1998, Experimental Brain Research.

[10]  R J Croft,et al.  Effects of rTMS on an Auditory Oddball Task: A Pilot Study of Cortical Plasticity and the EEG , 2008, Clinical EEG and neuroscience.

[11]  R. Knight,et al.  Contributions of temporal-parietal junction to the human auditory P3 , 1989, Brain Research.

[12]  A. Barker,et al.  NON-INVASIVE MAGNETIC STIMULATION OF HUMAN MOTOR CORTEX , 1985, The Lancet.

[13]  Simone Rossi,et al.  TMS in cognitive plasticity and the potential for rehabilitation , 2004, Trends in Cognitive Sciences.

[14]  E. Halgren,et al.  Generators of the late cognitive potentials in auditory and visual oddball tasks. , 1998, Electroencephalography and clinical neurophysiology.

[15]  E. Wassermann.  Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. , 1998, Electroencephalography and clinical neurophysiology.

[16]  Hongkui Jing,et al.  Effects of high frequency repetitive transcranial magnetic stimulation on P300 event-related potentials , 2001, Clinical Neurophysiology.

[17]  Á. Pascual-Leone,et al.  Study and modulation of human cortical excitability with transcranial magnetic stimulation. , 1998, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[18]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[19]  M. Bear,et al.  Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M J Eckardt,et al.  Dose-related effects of ethanol on visual sustained attention and event-related potentials. , 1987, Alcohol.

[21]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[22]  M. Hallett,et al.  Depression of motor cortex excitability by low‐frequency transcranial magnetic stimulation , 1997, Neurology.

[23]  R. J. Ilmoniemi,et al.  Prefrontal transcranial magnetic stimulation produces intensity-dependent EEG responses in humans , 2005, NeuroImage.

[24]  J. Polich,et al.  Cognitive and biological determinants of P300: an integrative review , 1995, Biological Psychology.

[25]  Idil Cavus,et al.  Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. , 2002, The American journal of psychiatry.

[26]  K. Iramina,et al.  Effect of transcranial magnetic stimulation on P300 of event-related potential , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[27]  K. Meador,et al.  Cholinergic modulation of human P3 event‐related potentials , 1987, Neurology.

[28]  R. Johnson,et al.  Auditory and visual P300s in temporal lobectomy patients: evidence for modality-dependent generators. , 1989, Psychophysiology.

[29]  W. Marsden.  I and J , 2012 .

[30]  J. Rothwell,et al.  Is there a future for therapeutic use of transcranial magnetic stimulation? , 2007, Nature Reviews Neuroscience.

[31]  M. Bear,et al.  Common forms of synaptic plasticity in the hippocampus and neocortex in vitro. , 1993, Science.

[32]  J. Rothwell,et al.  Techniques and mechanisms of action of transcranial stimulation of the human motor cortex , 1997, Journal of Neuroscience Methods.

[33]  D. Schutter.  Quantitative review of the efficacy of slow-frequency magnetic brain stimulation in major depressive disorder , 2010, Psychological Medicine.

[34]  T Takayanagi,et al.  A clinicophysiologic study of central and peripheral motor conduction in hereditary demyelinating motor and sensory neuropathy. , 1993, Electromyography and clinical neurophysiology.

[35]  Peter Brugger,et al.  Suppressing versus releasing a habit: frequency-dependent effects of prefrontal transcranial magnetic stimulation. , 2005, Cerebral cortex.

[36]  M. Hallett.  Transcranial Magnetic Stimulation: A Primer , 2007, Neuron.

[37]  S H Lisanby,et al.  Animal models of the mechanisms of action of repetitive transcranial magnetic stimulation (RTMS): Comparisons with electroconvulsive shock (ECS) , 2000, Depression and anxiety.