Increased temperature of malignant urinary bladder tumors in vivo: the application of a new method based on a catheter technique.

PURPOSE The aim of this study was to investigate the existence of any thermal difference between malignant tumors and inflammatory benign lesions of the human urinary bladder and to determine whether it correlates with tumor angiogenesis quantification. PATIENTS AND METHODS A new method, developed in our institute, is introduced to detect temperature in human urinary bladder, in vivo. This method is based on a thermography catheter. We calculated the differences of the temperature of the solid tumor and of a normal area (Delta T) on 20 subjects (mean age, 72.5 years; 95% confidence interval [CI], 68.5 to 76.4). According to the biopsy histology, Eight (40%) patients had benign tumors, and 12 (60%) had malignant tumors. RESULTS We found significant differences of Delta T between patients with benign and malignant tumor (P <.001). Also, differences were found for the mean values of angiogenesis level between malignant and benign tumors (P =.0261), and a moderated positive correlation was estimated between the degree of angiogenesis and Delta T (P =.02). Based on logistic regression analysis, we found that a 1-degree increase of Delta T triples the odds of a patient having a malignant tumor (odds ratio = 2.91; 95% CI, 1.97 to 7.78; P <.001), adjusted for the degree of angiogenesis (P =.0236) and the grade of tumor (P <.001). A threshold point of Delta T = 0.7 degrees C was determined, with sensitivity 83% and specificity 75%. CONCLUSION These findings suggest that the calculated difference of temperature between normal tissue and neoplastic area could be a useful criterion in the diagnosis of malignancy in tumors of the human urinary bladder.

[1]  R M Henkelman,et al.  Prostate cancer: MR imaging and thermometry during microwave thermal ablation-initial experience. , 2000, Radiology.

[2]  A. Llombart‐Bosch,et al.  Angiogenesis in neuroblastoma: relationship to survival and other prognostic factors in a cohort of neuroblastoma patients. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  M. Eisen,et al.  Current imaging modalities for the diagnosis of breast cancer. , 1999, Delaware medical journal.

[4]  W. Ko,et al.  Epstein-Barr virus-containing T-cell lymphoma and atherosclerotic abdominal aortic aneurysm in a young adult. , 1999, Human pathology.

[5]  W. Ryder,et al.  Prognostic relevance of micro-vessel density in cancer of the urinary bladder. , 1999, Anticancer research.

[6]  P Toutouzas,et al.  Thermal heterogeneity within human atherosclerotic coronary arteries detected in vivo: A new method of detection by application of a special thermography catheter. , 1999, Circulation.

[7]  J. Isner,et al.  Cancer and atherosclerosis: the broad mandate of angiogenesis. , 1999, Circulation.

[8]  N Hosten,et al.  Comparison of four magnetic resonance methods for mapping small temperature changes , 1999, Physics in medicine and biology.

[9]  C. Stefanadis,et al.  In vivo local thermography of coronary artery atherosclerotic plaques in humans. , 1998, Annals of internal medicine.

[10]  A. Harris,et al.  Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer. , 1997, Cancer research.

[11]  G. Bastert,et al.  [Diagnosis of blood flow in breast tumors with increased blood pressure. New possibility in tumor field diagnosis]. , 1997, Der Radiologe.

[12]  S. Sengupta,et al.  Thermography: Its relation to pathologic characteristics, vascularity, proliferation rate, and survival of patients with invasive ductal carcinoma of the breast , 1996, Cancer.

[13]  T. Stephenson,et al.  Prognostic significance of angiogenesis in transitional cell carcinoma of the human urinary bladder. , 1996, British journal of urology.

[14]  A. Rademaker,et al.  Tumor angiogenesis correlates with metastatic disease, N-myc amplification, and poor outcome in human neuroblastoma. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  S Marakas,et al.  Pressure-diameter relation of the human aorta. A new method of determination by the application of a special ultrasonic dimension catheter. , 1995, Circulation.

[16]  A. Harris,et al.  Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  S. Fox,et al.  Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas. , 1994, British journal of urology.

[18]  C. Vlachopoulos,et al.  Retrograde Nontransseptal Balloon Mitral Valvuloplast: Immediate Results and Long‐term Follow‐up , 1992, Circulation.

[19]  F. Arnold.  Exploiting angiogenesis , 1991, The Lancet.

[20]  J. Folkman,et al.  Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. , 1991, The New England journal of medicine.

[21]  N Paweletz,et al.  Tumor-related angiogenesis. , 1989, Critical reviews in oncology/hematology.

[22]  R. Bouvier,et al.  Clinically occult bladder cancer diagnosis. Trial using ultraviolet cystoscopy , 1985, Cancer.

[23]  S. Kumar,et al.  Tumour angiogenesis factor in urological cancers. , 1984, British journal of urology.

[24]  K. Igarashi,et al.  In vivo staining test with methylene blue for bladder cancer. , 1983, The Journal of urology.

[25]  M. Melamed,et al.  Flow cytometry of low stage bladder tumors: Correlation with cytologic and cystoscopic diagnosis , 1982, Cancer.

[26]  M. Melamed,et al.  CARCINOGENESIS IN THE HUMAN URINARY BLADDER: OBSERVATIONS AFTER EXPOSURE TO PARA-AMINODIPHENYL. , 1965, The New England journal of medicine.