Indocyanine green-laser thermolysis of acne vulgaris

The near-infrared (NIR) laser radiation due to its high penetration depth is widely used in phototherapy and photothermolysis. In application to skin appendages a high selectivity of laser treatment is needed to prevent light action on surrounding tissues. Indocyanine Green (ICG) dye may provide a high selectivity of treatment due to effective ICG uploading by a target and its narrow band of considerable absorption just at the wavelength of the NIR diode laser. The goal of this study is to demonstrate the efficacy of the NIR diode laser photothermolysis in combination with topical application of ICG suggested for treatment of acne vulgaris. Two volunteers with back-located acne were enrolled. Skin sites of subjects were stained by ICG and irradiated by NIR laser-diode light (803 or 809 nm). The individual acne lesions were photothermally treated at 18 W/cm2 (803 nm, 0.5 sec) without skin surface cooling or at 200 W/cm2 (809 nm, 0.5 sec) with cooling. The results of the observations during a month after the treatment have shown that ICG stained acne inflammatory elements were destructed for light exposures of 0.5 sec.

[1]  H. Pass,et al.  Photodynamic therapy in oncology: mechanisms and clinical use. , 1993, Journal of the National Cancer Institute.

[2]  Griffin Jp.  A review of the literature on benign intracranial hypertension associated with medication. , 1992, Adverse drug reactions and toxicological reviews.

[3]  W. Cunliffe,et al.  Phototherapy and acne vulgaris , 2000, The British journal of dermatology.

[4]  F. Green,et al.  The Sigma-Aldrich Handbook of Stains, Dyes and Indicators , 1990 .

[5]  F. Dunstan,et al.  Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996-8 , 1999, BMJ.

[6]  Christoph Abels,et al.  Indocyanine green (ICG) and laser irradiation induce photooxidation , 2000, Archives of Dermatological Research.

[7]  Alan R. Shalita,et al.  Acne phototherapy using UV-free high-intensity narrow-band blue light: a three-center clinical study , 2001, SPIE BiOS.

[8]  J. Czernielewski,et al.  Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne , 2001, Journal of the European Academy of Dermatology and Venereology : JEADV.

[9]  K. Bartels,et al.  Photothermal effects on murine mammary tumors using indocyanine green and an 808-nm diode laser: an in vivo efficacy study. , 1996, Cancer letters.

[10]  K. Charalabopoulos,et al.  Two new adverse effects of isotretinoin , 2003, The British journal of dermatology.

[11]  R. Anderson,et al.  Contact cooling of the skin. , 1999, Physics in medicine and biology.

[12]  Valery V. Tuchin,et al.  In-vitro study of penetration of magnetic particles into the human skin , 2000, Optics and Optoelectronic Inspection and Control.

[13]  Kai-Ming Lo,et al.  Uptake of indocyanine green by hamster sebaceous glands , 2001, SPIE BiOS.

[14]  W. Cunliffe,et al.  Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage. , 1993, BMJ.

[15]  R. Stern.  When a uniquely effective drug is teratogenic. The case of isotretinoin. , 1989, The New England journal of medicine.

[16]  M. Mihm,et al.  Photodynamic Therapy for Nevus Sebaceus With Topical δ-Aminolevulinic Acid , 1999 .

[17]  S. Mashiko,et al.  Singlet Oxygen (1Δg) Generation from Coproporphyrin inPropionibacterium acneson Irradiation , 1996 .

[18]  M Landthaler,et al.  Photo-oxidative killing of human colonic cancer cells using indocyanine green and infrared light , 1999, British Journal of Cancer.

[19]  P. Papageorgiou,et al.  Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris , 2000, The British journal of dermatology.

[20]  J. Prins,et al.  Apoptosis of human adipocytes in vitro. , 1994, Biochemical and biophysical research communications.

[21]  A. Johnsson,et al.  AN ACTION SPECTRUM FOR BLUE AND NEAR ULTRAVIOLET IN ACTIVATION OF Propionibacterium acnes; WITH EMPHASIS ON A POSSIBLE PORPHYRIN PHOTOSENSITIZATION , 1986, Photochemistry and photobiology.

[22]  I. Schweitzer,et al.  The Association Between Depression and Isotretinoin Use in Acne , 2003, The Australian and New Zealand journal of psychiatry.

[23]  S. Mordon,et al.  A new method to improve penetration depth of dyes into the follicular duct: potential application for laser hair removal. , 1999, Journal of the American Academy of Dermatology.

[24]  J. Wolf,et al.  An update of recent clinical trials examining adapalene and acne , 2001, Journal of the European Academy of Dermatology and Venereology : JEADV.

[25]  Valery V Tuchin,et al.  In vitro and in vivo study of dye diffusion into the human skin and hair follicles. , 2002, Journal of biomedical optics.

[26]  A. Knulst,et al.  Phototherapy of acne vulgaris with visible light. , 1997, Dermatology.

[27]  Peter J. Dwyer,et al.  Photodynamic Therapy for Nevus Sebaceus With Topical δ-Aminolevulinic Acid , 1999 .

[28]  G. Altshuler,et al.  Extended theory of selective photothermolysis , 2001, Lasers in surgery and medicine.

[29]  E. Abel.  Minocycline-induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome , 1996 .

[30]  F. Carroll,et al.  Evaluation of Retinoids as Therapeutic Agents in Dermatology , 1994, Pharmaceutical Research.

[31]  Valery V. Tuchin,et al.  Double-wavelength laser scanning microphotometer (DWLSM) for in-vitro hair shaft and surrounding tissue imaging , 2001, SPIE BiOS.

[32]  B. Kitchell,et al.  The biology of melanocytes. , 2003, Veterinary dermatology.

[33]  Jenifer R. Lloyd,et al.  Selective photothermolysis of the sebaceous glands for acne treatment , 2002, Lasers in surgery and medicine.

[34]  F. Flowers,et al.  Extensive cutaneous hyperpigmentation caused by minocycline. , 1993, Journal of the American Academy of Dermatology.

[35]  M Landthaler,et al.  Indocyanine green: intracellular uptake and phototherapeutic effects in vitro. , 1997, Journal of photochemistry and photobiology. B, Biology.

[36]  K. Bartels,et al.  Chromophore-enhanced in vivo tumor cell destruction using an 808-nm diode laser. , 1995, Cancer letters.

[37]  R. Anderson,et al.  Topical ALA-photodynamic therapy for the treatment of acne vulgaris. , 2000, The Journal of investigative dermatology.

[38]  J. Griffin.  A review of the literature on benign intracranial hypertension associated with medication. , 1992, Adverse drug reactions and toxicological reviews.