The Relationship between the Dietary Inflammatory Index (DII) and Metabolic Syndrome (MetS) in Middle-Aged and Elderly Individuals in the United States

(1) Background: With the aging demographic shift in society, there is a growing number of middle-aged and elderly individuals affected by metabolic syndrome (MetS), a risk factor contributing to all causes of mortality. Inflammation plays a crucial role in the development of MetS. This study aims to examine the correlation between MetS and pro-inflammatory diets in middle-aged and elderly individuals, utilizing the Dietary Inflammation Index (DII) as a measure. (2) Methods: Data were extracted from the 2007–2016 National Health and Nutrition Examination Survey (NHANES) database for individuals who were 45 years of age or older. The DII was determined for each participant through 24-h dietary recall interviews. The relationship between DII and MetS was assessed using binary logistic regression analysis, and the association between DII and MetS-related indicators was further explored through generalized linear model (GLM) and quantile regression analysis. (3) Results: A total of 3843 middle-aged and elderly individuals were included in the study. After controlling for confounding factors, the highest quartile of DII was associated with a higher risk of MetS (ORQ4:Q1 = 1.339; 95% CI: 1.013, 1.769; p for trend = 0.018). The top DII quartile also increased the risk of reduced HDL-C (ORQ4:Q1 = 1.499; 95% CI: 1.005, 2.234; p for trend = 0.048) and raised FG (ORQ4:Q1 = 1.432; 95% CI: 1.095, 1.873; p for trend = 0.010) compared to the lowest DII quartile. The levels of DII were found to be positively correlated with BMI (β = 0.258, p = 0.001), FPG (β = 0.019, p = 0.049), TG (β = 2.043, p = 0.013), waistline (β = 0.580, p = 0.002), and negatively correlated with HDL-C (β = −0.672, p = 0.003). (4) Conclusions: In middle-aged and elderly individuals in the United States, a high DII score has been linked to the presence of MetS, low HDL-C, and hyperglycemia. Therefore, dietary recommendations for the middle-aged and elderly should focus on reducing the DII by choosing foods rich in antioxidants, dietary fiber, and unsaturated fatty acids.

[1]  Fan Zhang,et al.  Metaflammation in glucolipid metabolic disorders: Pathogenesis and treatment. , 2023, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[2]  G. Frühbeck,et al.  The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome , 2022, Nutrients.

[3]  Rohit Sharma,et al.  Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review , 2022, Food Science and Biotechnology.

[4]  Xian-ping Wu,et al.  Prevalence of metabolic syndrome among the adult population in western China and the association with socioeconomic and individual factors: four cross-sectional studies , 2022, BMJ Open.

[5]  YunJae Jung,et al.  Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women , 2021, Nutrients.

[6]  Qingxiang Li,et al.  Association of dietary inflammatory index and metabolic syndrome in the elderly over 55 years in Northern China , 2021, British Journal of Nutrition.

[7]  M. Wolters,et al.  The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society , 2021, Nutrients.

[8]  M. Harding,et al.  Emotional Eating in Adults: The Role of Sociodemographics, Lifestyle Behaviors, and Self-Regulation—Findings from a U.S. National Study , 2020, International journal of environmental research and public health.

[9]  N. Shivappa,et al.  Dietary Inflammatory Index is associated with Healthy Eating Index, Alternative Healthy Eating Index, and dietary patterns among Iranian adults , 2020, Journal of clinical laboratory analysis.

[10]  E. Denova-Gutiérrez,et al.  Dietary Inflammatory Index and metabolic syndrome in Mexican adult population. , 2020, The American journal of clinical nutrition.

[11]  S. Hanash,et al.  Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study , 2020, British Journal of Nutrition.

[12]  A. Akyol,et al.  Is there a relationship between the dietary inflammatory index and metabolic syndrome among adolescents? , 2020, Journal of pediatric endocrinology & metabolism : JPEM.

[13]  A. Esteghamati,et al.  Association between dietary inflammatory index and components of metabolic syndrome , 2019, Journal of cardiovascular and thoracic research.

[14]  Md. Hafiz Uddin,et al.  Advancing age, influence of dietary sugars, salts, and fats on chronic diseases and metabolic disorders , 2020 .

[15]  S. Pavičić Žeželj,et al.  Metabolic syndrome and its association with the Dietary Inflammatory Index (DII)® in a Croatian working population. , 2019, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

[16]  Alejandro Lucia,et al.  Chronic inflammation in the etiology of disease across the life span , 2019, Nature Medicine.

[17]  B. Balkau,et al.  Dietary inflammatory index and type 2 diabetes risk in a prospective cohort of 70,991 women followed for 20 years: the mediating role of BMI , 2019, Diabetologia.

[18]  B. Heude,et al.  Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review , 2019, Nutrients.

[19]  I. Jialal,et al.  Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes. , 2019, Clinica chimica acta; international journal of clinical chemistry.

[20]  S. Mazloomzadeh,et al.  Metabolic syndrome, its components and mortality: A population-based study , 2019, Medical journal of the Islamic Republic of Iran.

[21]  M. Libra,et al.  Dietary Inflammatory Index in Ageing and Longevity , 2019, Centenarians.

[22]  B. Yıldız,et al.  Metabolic syndrome during menopause. , 2019, Current vascular pharmacology.

[23]  N. Shivappa,et al.  Association between the Dietary Inflammatory Index (DII) and urinary enterolignans and C-reactive protein from the National Health and Nutrition Examination Survey-2003–2008 , 2019, European Journal of Nutrition.

[24]  I. Lambrinoudaki,et al.  Menopause and diabetes: EMAS clinical guide. , 2018, Maturitas.

[25]  N. Shivappa,et al.  The association between dietary inflammatory index and metabolic syndrome components in Iranian adults. , 2018, Primary care diabetes.

[26]  S. Khaliq,et al.  Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links , 2018, Hormones.

[27]  B. Larijani,et al.  Dietary Inflammatory Index and its Association with the Risk of Cardiovascular Diseases, Metabolic Syndrome, and Mortality: A Systematic Review and Meta-Analysis , 2018, Hormone and Metabolic Research.

[28]  Jeongseon Kim,et al.  Association between Dietary Inflammatory Index and Metabolic Syndrome in the General Korean Population , 2018, Nutrients.

[29]  D. Giugliano,et al.  From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome , 2018, Journal of Endocrinological Investigation.

[30]  M. Saklayen.  The Global Epidemic of the Metabolic Syndrome , 2018, Current Hypertension Reports.

[31]  T. Simoncini,et al.  Symptoms of menopause — global prevalence, physiology and implications , 2018, Nature Reviews Endocrinology.

[32]  Chien-Yeh Hsu,et al.  Association of Dietary Patterns with Components of Metabolic Syndrome and Inflammation among Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan , 2018, Nutrients.

[33]  M. Correa-Rodríguez,et al.  Dietary Inflammatory Index and Cardiometabolic Risk Parameters in Overweight and Sedentary Subjects , 2017, International journal of environmental research and public health.

[34]  C. Drevon,et al.  Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation , 2017, Nutrition reviews.

[35]  W. Liao,et al.  Influence of diet on the gut microbiome and implications for human health , 2017, Journal of Translational Medicine.

[36]  M. Mendez,et al.  Metabolism disrupting chemicals and metabolic disorders. , 2017, Reproductive toxicology.

[37]  R. Jayawardena,et al.  Prevalence and trends of metabolic syndrome among adults in the asia-pacific region: a systematic review , 2017, BMC Public Health.

[38]  C. Sohn,et al.  Analysis of Dietary Inflammatory Index of Metabolic Syndrome in Korean: Data from the Health Examinee Cohort (2012-2014) , 2016 .

[39]  James R Hébert,et al.  Anti-inflammatory Dietary Inflammatory Index scores are associated with healthier scores on other dietary indices. , 2016, Nutrition research.

[40]  D. Azagury,et al.  Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA). , 2016, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[41]  J. Dwyer,et al.  Update on NHANES Dietary Data: Focus on Collection, Release, Analytical Considerations, and Uses to Inform Public Policy , 2016, Advances in nutrition.

[42]  M. Touvier,et al.  Prospective association between the dietary inflammatory index and metabolic syndrome: findings from the SU.VI.MAX study. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[43]  R. Wong,et al.  Prevalence of the metabolic syndrome in the United States, 2003-2012. , 2015, JAMA.

[44]  J. Martínez,et al.  Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. , 2015, The British journal of nutrition.

[45]  L. O’Driscoll,et al.  Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies , 2015, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[46]  G. Escobedo,et al.  [Low-grade systemic inflammation and the development of metabolic diseases: from the molecular evidence to the clinical practice]. , 2015, Cirugia y cirujanos.

[47]  James R Hébert,et al.  Association of a Dietary Inflammatory Index With Inflammatory Indices and Metabolic Syndrome Among Police Officers , 2014, Journal of occupational and environmental medicine.

[48]  K. Herzig,et al.  A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects , 2014, European Journal of Nutrition.

[49]  N. Shivappa,et al.  Designing and developing a literature-derived, population-based dietary inflammatory index , 2013, Public Health Nutrition.

[50]  D. Panagiotakos,et al.  The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. , 2011, Journal of the American College of Cardiology.

[51]  L. Galland.  Diet and inflammation. , 2010, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[52]  W. Janssens,et al.  METABOLIC SYNDROME IN THE ELDERLY: AN OVERVIEW OF THE EVIDENCE , 2009, Acta clinica Belgica.

[53]  L. Miles,et al.  Physical activity and health , 2007 .

[54]  S. Grundy,et al.  The metabolic syndrome , 2003, The Lancet.