Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study
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M. Laakso | T. Valle | F. T. E. Group | J. Eriksson | J. Lindström | H. Hämäläinen | P. Ilanne-Parikka | S. Keinänen-Kiukaanniemi | M. Uusitupa | J. Tuomilehto | T. Salopuro | L. Pulkkinen | P Ilanne-Parikka | J. Eriksson
[1] A. de Leiva,et al. Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test , 2000, Diabetologia.
[2] E. Ravussin,et al. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism , 2002, International Journal of Obesity.
[3] A. Golay,et al. Pathways from obesity to diabetes , 2002, International Journal of Obesity.
[4] E. Ravussin,et al. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. , 1997, Human molecular genetics.
[5] K. Nakao,et al. Association of Ob-R gene polymorphism and insulin resistance in Japanese men. , 2004, Metabolism: clinical and experimental.
[6] Y. Chagnon,et al. Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long‐term overfeeding , 2000, Journal of internal medicine.
[7] M. Saad,et al. Association of leptin receptor polymorphism with insulin resistance. , 2004, European journal of endocrinology.
[8] K. Hofbauer. Molecular pathways to obesity , 2002, International Journal of Obesity.
[9] W. Chung,et al. Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity. , 1997, Biochemical and biophysical research communications.
[10] H. Lakka,et al. The common pentanucleotide polymorphism of the 3′‐untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in non‐diabetic men: a prospective case–control study , 2000, Journal of internal medicine.
[11] K. Clément,et al. Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families , 1997, Human Genetics.
[12] T. Valle,et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. , 2001, The New England journal of medicine.
[13] R. Eastell,et al. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women , 2001, Human Genetics.
[14] C. Bouchard,et al. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. , 2000, The Journal of clinical endocrinology and metabolism.
[15] M. Hutz,et al. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil , 2002, International Journal of Obesity.
[16] J. Kaprio,et al. A common pentanucleotide polymorphism of the 3′-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals , 1998, International Journal of Obesity.
[17] E. Ravussin,et al. Human genomics and obesity: finding appropriate drug targets. , 2000, European journal of pharmacology.
[18] T. Saruta,et al. Effects of leptin receptor gene 3'-untranslated region polymorphism on metabolic profiles in young Japanese men. , 2004, Journal of atherosclerosis and thrombosis.
[19] O. Pedersen,et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference , 2002, International Journal of Obesity.
[20] P. McKeigue,et al. Leptin receptor gene variation and obesity: lack of association in a white British male population. , 1997, Human molecular genetics.
[21] W. Saris,et al. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. , 2003, Obesity research.
[22] C. Bouchard,et al. Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. , 2002, Obesity research.
[23] T. Valle,et al. The Finnish Diabetes Prevention Study , 2000, British Journal of Nutrition.
[24] J. Gerich,et al. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. , 1998, Endocrine reviews.
[25] Y. Chagnon,et al. Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women , 2001, International Journal of Obesity.
[26] J. Habener,et al. Leptin receptors expressed on pancreatic beta-cells. , 1996, Biochemical and biophysical research communications.
[27] T. Valle,et al. Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland Study design and 1-year interim report on the feasibility of the lifestyle intervention programme , 1999, Diabetologia.
[28] T. Valle,et al. Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort. , 2004, Diabetes care.
[29] C. Bouchard,et al. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study. , 2004, Diabetes.
[30] J. Chan,et al. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. , 2001, The Journal of clinical endocrinology and metabolism.
[31] C. Bouchard,et al. Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. , 2001, The Journal of clinical endocrinology and metabolism.