An in‐vitro–in‐vivo taste assessment of bitter drug: comparative electronic tongues study

The efficiency of the Astree e‐tongue and Taste Sensing system TS5000Z for the evaluation of the taste masking effect of hot melt extruded formulations was investigated in this study.

[1]  Mohammed Maniruzzaman,et al.  Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. , 2011, Colloids and surfaces. B, Biointerfaces.

[2]  Peter Kleinebudde,et al.  Taste sensing systems (electronic tongues) for pharmaceutical applications. , 2011, International journal of pharmaceutics.

[3]  S. Hoag,et al.  Influence of various drugs on the glass transition temperature of poly(vinylpyrrolidone): a thermodynamic and spectroscopic investigation. , 2001, International journal of pharmaceutics.

[4]  G. Mateescu,et al.  Infrared Spectroscopy: Applications in Organic Chemistry , 1972 .

[5]  P. Belton,et al.  Characterisation of solid dispersions of paracetamol and EUDRAGIT E prepared by hot-melt extrusion using thermal, microthermal and spectroscopic analysis. , 2008, International journal of pharmaceutics.

[6]  M. Maniruzzaman,et al.  An in‐vivo and in‐vitro taste masking evaluation of bitter melt‐extruded drugs , 2014, The Journal of pharmacy and pharmacology.

[7]  H. K. Lee,et al.  Propranolol:methacrylic acid copolymer binding interaction. , 1991, Journal of pharmaceutical sciences.

[8]  Patrycja Ciosek,et al.  Electronic tongue for the detection of taste-masking microencapsulation of active pharmaceutical substances. , 2010, Bioelectrochemistry.

[9]  P. Kleinebudde,et al.  Rational development of taste masked oral liquids guided by an electronic tongue. , 2010, International journal of pharmaceutics.

[10]  J. Boateng,et al.  Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[11]  Alisa Rudnitskaya,et al.  Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects , 2004, Analytical and bioanalytical chemistry.

[12]  J. Ley,et al.  Masking Bitter Taste by Molecules , 2008 .

[13]  Patrycja Ciosek,et al.  Sensor arrays for liquid sensing--electronic tongue systems. , 2007, The Analyst.

[14]  Patrycja Ciosek,et al.  The Recognition of Growth Conditions and Metabolic Type of Plants by a Potentiometric Electronic Tongue , 2006 .

[15]  David S. Jones,et al.  Hot-melt extrusion technology and pharmaceutical application. , 2012, Therapeutic delivery.

[16]  David S Jones,et al.  Understanding the performance of melt-extruded poly(ethylene oxide)-bicalutamide solid dispersions: characterisation of microstructural properties using thermal, spectroscopic and drug release methods. , 2012, Journal of pharmaceutical sciences.

[17]  P. Kleinebudde,et al.  A comparative study on two electronic tongues for pharmaceutical formulation development. , 2011, Journal of pharmaceutical and biomedical analysis.

[18]  Jun Wang,et al.  Discrimination and characterization of strawberry juice based on electronic nose and tongue: comparison of different juice processing approaches by LDA, PLSR, RF, and SVM. , 2014, Journal of agricultural and food chemistry.

[19]  M. Maniruzzaman,et al.  Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions. , 2013, International journal of pharmaceutics.

[20]  Sheng Qi,et al.  Characterisation and Prediction of Phase Separation in Hot-Melt Extruded Solid Dispersions: A Thermal, Microscopic and NMR Relaxometry Study , 2010, Pharmaceutical Research.

[21]  Patrycja Ciosek,et al.  The analysis of sensor array data with various pattern recognition techniques , 2006 .

[22]  J. Breitkreutz,et al.  Challenges of developing palatable oral paediatric formulations. , 2009, International journal of pharmaceutics.

[23]  G. Beauchamp,et al.  Optimizing oral medications for children. , 2008, Clinical therapeutics.