Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation

[1]  M. Peschanski,et al.  Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease. , 2004, Brain : a journal of neurology.

[2]  B. Weill,et al.  Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. , 2004, Transplantation.

[3]  C. Chagneau,et al.  Fluorescent activated cell sorting (FACS): a rapid and reliable method to estimate the number of neurons in a mixed population , 2003, Journal of Neuroscience Methods.

[4]  F. Cicchetti,et al.  Immune parameters relevant to neural xenograft survival in the primate brain , 2003, Xenotransplantation.

[5]  Mathias Hoehn,et al.  Monitoring of implanted stem cell migration in vivo: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[6]  U. Grohmann,et al.  CTLA-4–Ig regulates tryptophan catabolism in vivo , 2002, Nature Immunology.

[7]  P. Sanberg,et al.  Neural transplantation for treatment of Parkinson's disease. , 2002, Drug discovery today.

[8]  B. Melchior,et al.  Temporal analysis of cytokine gene expression during infiltration of porcine neuronal grafts implanted into the rat brain , 2002, Journal of neuroscience research.

[9]  B. Melchior,et al.  Different mechanisms mediate the rejection of porcine neurons and endothelial cells transplanted into the rat brain , 2001, Xenotransplantation.

[10]  Michiyasu Suzuki,et al.  Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirus , 2001, Brain Research.

[11]  Anne-Catherine Bachoud-Lévi,et al.  Motor and cognitive improvements in patients with Huntington's disease after neural transplantation , 2000, The Lancet.

[12]  H. Widner,et al.  Xenotransplantation for CNS repair: immunological barriers and strategies to overcome them , 2000, Trends in Neurosciences.

[13]  W. Low,et al.  Visualization of Antigen-Specific T Cell Activation in Vivo in Response to Intracerebral Administration of a Xenopeptide , 2000, Experimental Neurology.

[14]  J. Bloch,et al.  Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. , 2000, Human gene therapy.

[15]  J. Streilein,et al.  Systemic Immune Deviation in the Brain That Does Not Depend on the Integrity of the Blood-Brain Barrier1 , 2000, The Journal of Immunology.

[16]  R. Barker,et al.  A Role for Complement in the Rejection of Porcine Ventral Mesencephalic Xenografts in a Rat Model of Parkinson's Disease , 2000, The Journal of Neuroscience.

[17]  P. Brundin,et al.  Intrastriatal Ventral Mesencephalic Xenografts of Porcine Tissue in Rats: Immune Responses and Functional Effects , 2000, Cell transplantation.

[18]  R. Penn,et al.  Porcine Xenografts in Parkinson's Disease and Huntington's Disease Patients: Preliminary Results , 2000, Cell transplantation.

[19]  M. Ideguchi,et al.  Local adenovirus-mediated CTLA4-immunoglobulin expression suppresses the immune responses to adenovirus vectors in the brain , 1999, Neuroscience.

[20]  J. Marcilloux,et al.  Stereotaxic atlas of the pig brain , 1999, Brain Research Bulletin.

[21]  M. Dallman,et al.  Local gene therapy with CTLA4‐immunoglobulin fusion protein in experimental allergic encephalomyelitis , 1998, European journal of immunology.

[22]  A. Edge,et al.  Xenogeneic cell therapy: current progress and future developments in porcine cell transplantation. , 1998, Cell transplantation.

[23]  J. Zimmer,et al.  Proliferative response of human T lymphocytes to porcine fetal brain cells. , 1997, Cell transplantation.

[24]  T. Deacon,et al.  Neural transplantation studies reveal the brain's capacity for continuous reconstruction , 1997, Trends in Neurosciences.

[25]  R. Tanaka,et al.  Treatment of rat hemiparkinson model with xenogeneic neural transplantation: Tolerance induction by anti‐T‐cell antibodies , 1997, Journal of neuroscience research.

[26]  J. Zimmer,et al.  Triple immunosuppression protects murine intracerebral, hippocampal xenografts in adult rat hosts: effects on cellular infiltration, major histocompatibility complex antigen induction and blood–brain barrier leakage , 1997, Neuroscience.

[27]  Ole Isacson,et al.  Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease , 1997, Nature Medicine.

[28]  T. Deacon,et al.  Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology , 1996, Experimental Neurology.

[29]  D. Olive,et al.  Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association (*) , 1996, The Journal of Biological Chemistry.

[30]  M. Wood,et al.  Indefinite survival of neural xenografts induced with anti-CD4 monoclonal antibodies , 1996, Neuroscience.

[31]  T. Deacon,et al.  Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres , 1995, Nature Medicine.

[32]  O. Isacson,et al.  Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex. , 1995, Cell transplantation.

[33]  P. Linsley,et al.  Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment. , 1995, Journal of immunology.

[34]  T. Deacon,et al.  A novel mode of immunoprotection of neural xenotransplants: Masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system , 1995, Neuroscience.

[35]  G. Hoffman,et al.  cFos immunoreactivity is enhanced with biotin amplification. , 1994, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[36]  O. Isacson,et al.  Cytoarchitectonic Development, Axon-Glia Relationships, and Long Distance Axon Growth of Porcine Striatal Xenografts in Rats , 1994, Experimental Neurology.

[37]  P. Linsley,et al.  CTLA4Ig treatment ameliorates the lethality of murine graft-versus-host disease across major histocompatibility complex barriers. , 1994, Transplantation.

[38]  T. Terasaki,et al.  Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. , 1993, Biochemical pharmacology.

[39]  P. Linsley,et al.  CTLA-4 is a second receptor for the B cell activation antigen B7 , 1991, The Journal of experimental medicine.

[40]  Richard S. J. Frackowiak,et al.  Transplanted allogeneic fetal dopamine neurons survive and improve motor function in idiopathic Parkinson's disease. , 1991, Transplantation proceedings.

[41]  R. Palmiter,et al.  Expression and performance in transgenic pigs. , 1990, Journal of reproduction and fertility. Supplement.

[42]  M. Nerenberg,et al.  Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control , 1990, Neuron.

[43]  C D Marsden,et al.  Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. , 1990, Science.

[44]  A. Graybiel,et al.  Cellular substrate of the histochemically defined striosome/matrix system of the caudate nucleus: A combined golgi and immunocytochemical study in cat and ferret , 1988, Neuroscience.