Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

P. O’Reilly | M. Jarvelin | J. Danesh | D. Kiel | C. Gieger | A. Uitterlinden | T. Spector | L. Ferrucci | M. McCarthy | T. Lehtimäki | E. Boerwinkle | R. Vasan | H. Völzke | O. Raitakari | F. Rivadeneira | S. Booth | B. Kestenbaum | C. Robinson-Cohen | I. D. de Boer | D. Houston | K. Lohman | Yongmei Liu | S. Kritchevsky | K. Michaëlsson | Thomas J. Wang | P. Kraft | N. Sattar | S. Ripatti | E. Ingelsson | D. Albanes | S. Weinstein | J. Rotter | L. Lind | W. März | N. Freedman | N. Wareham | J. Dupuis | M. Beekman | J. Deelen | E. Hyppönen | J. Eriksson | C. Power | J. Richards | L. Cupples | J. Jukema | M. Heijer | M. Ikram | E. Slagboom | S. Rich | C. Hayward | P. Joshi | H. Campbell | M. Kähönen | James F. Wilson | H. Aschard | J. Luan | N. Forouhi | C. Langenberg | C. Ohlsson | M. Econs | Ching‐Ti Liu | E. Tikkanen | K. Khaw | M. Kleber | L. Lyytikäinen | E. Theodoratou | A. Butterworth | M. den Heijer | H. Wallaschofski | M. Zillikens | M. Lorentzon | L. Vandenput | L. Zgaga | A. Valdes | S. Trompet | S. Pilz | N. V. van Schoor | N. van der Velde | L. Broer | A. Cavadino | Y. Hsu | P. Lutsey | E. Michos | S. Farrington | M. Dunlop | Ang Zhou | M. Timofeeva | D. Karasik | M. Peacock | E. Streeten | Yanhua Zhou | Weihong Tang | Ju-Sheng Zheng | M. Shea | Xia Jiang | E. Sofianopoulou | D. Berry | A. Wood | D. Heemst | L. Yao | A. Enneman | L. Groot | N. Velde | Wen-Yi Huang | J. B. Richards | T. Gundersen | I. H. Boer | V. Mikkilä | A. Zhou | M. Kähönen | J. Eriksson | A. Uitterlinden | Natasja M. Schoor | J. Eriksson | M. McCarthy | J. B. Richards | Ian H. de Boer | M. McCarthy | M. den Heijer | Nathalie van der Velde

[1]  anonymous,et al.  Comprehensive review , 2019 .

[2]  D. Kiel,et al.  Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. , 2018, American journal of human genetics.

[3]  D. Kiel,et al.  Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. , 2017, American journal of human genetics.

[4]  David A. Jolliffe,et al.  Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data , 2017, British Medical Journal.

[5]  Ba,et al.  Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk , 2016, Neurology: Genetics.

[6]  Hugues Aschard,et al.  A perspective on interaction effects in genetic association studies , 2016, Genetic epidemiology.

[7]  W. März,et al.  Vitamin D and cardiovascular disease prevention , 2016, Nature Reviews Cardiology.

[8]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[9]  Jonathan P. Beauchamp,et al.  Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses , 2016, Nature Genetics.

[10]  M. Kwon,et al.  Analysis of 25‐Hydroxyvitamin D Status According to Age, Gender, and Seasonal Variation , 2016, Journal of clinical laboratory analysis.

[11]  C. Spencer,et al.  A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects: CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium , 2016, bioRxiv.

[12]  J. Rioux,et al.  Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus , 2015, Nature Genetics.

[13]  Casey S. Greene,et al.  International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways , 2015, Nature Communications.

[14]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[15]  C. Greenwood,et al.  Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study , 2015, PLoS medicine.

[16]  Duane D. Miller,et al.  The role of vitamin D in cancer prevention. , 2015, Chinese journal of natural medicines.

[17]  田原 康玄,et al.  生活習慣病とgenome-wide association study , 2015 .

[18]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[19]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[20]  Epidemiology Branch.  Genome-Wide Meta-Analysis of Joint Tests for Genetic and Gene-Environment Interaction Effects , 2015 .

[21]  N. Wray,et al.  Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins , 2014, Twin Research and Human Genetics.

[22]  Han Xu,et al.  Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. , 2014, American journal of human genetics.

[23]  I. Ntalla,et al.  A genome-wide association study of anorexia nervosa , 2011, Molecular Psychiatry.

[24]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[25]  T. Meehan,et al.  An atlas of active enhancers across human cell types and tissues , 2014, Nature.

[26]  Jun S. Liu,et al.  Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .

[27]  R. Young,et al.  Super-Enhancers in the Control of Cell Identity and Disease , 2013, Cell.

[28]  Tanya M. Teslovich,et al.  Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.

[29]  M. Daly,et al.  Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis , 2013, The Lancet.

[30]  Buhm Han,et al.  Chromatin marks identify critical cell types for fine mapping complex trait variants , 2012 .

[31]  M. Gershwin,et al.  The Implication of Vitamin D and Autoimmunity: a Comprehensive Review , 2013, Clinical Reviews in Allergy & Immunology.

[32]  E. Rimm,et al.  Exploring the Genetic Architecture of Circulating 25‐Hydroxyvitamin D , 2013, Genetic epidemiology.

[33]  William Stafford Noble,et al.  Integrative annotation of chromatin elements from ENCODE data , 2012, Nucleic acids research.

[34]  Y. Shoenfeld,et al.  Vitamin D in Systemic and Organ-Specific Autoimmune Diseases , 2013, Clinical Reviews in Allergy & Immunology.

[35]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[36]  Data production leads,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[37]  Manolis Kellis,et al.  Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions , 2012, Science.

[38]  Tanya M. Teslovich,et al.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.

[39]  ENCODEConsortium,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[40]  P. Visscher,et al.  Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.

[41]  Disorder Working Group.  Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 , 2012, Nature Genetics.

[42]  Manuel A. R. Ferreira,et al.  Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 , 2011, Nature Genetics.

[43]  Albert J. Vilella,et al.  A high-resolution map of human evolutionary constraint using 29 mammals , 2011, Nature.

[44]  C. Haldeman-Englert,et al.  Cranio‐lenticulo‐sutural dysplasia associated with defects in collagen secretion , 2011, Clinical genetics.

[45]  N. Mehta.  Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. , 2011, Circulation. Cardiovascular genetics.

[46]  T. Spector,et al.  Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes , 2011, Diabetes.

[47]  Josée Dupuis,et al.  Meta‐analysis of gene‐environment interaction: joint estimation of SNP and SNP × environment regression coefficients , 2011, Genetic epidemiology.

[48]  J. Kim,et al.  Well-Differentiated Liposarcoma of the Oesophagus: Clinicopathological, Immunohistochemical and Array CGH Analysis , 2011, Pathology & Oncology Research.

[49]  Peter Kraft,et al.  Genome-Wide Meta-Analysis of Joint Tests for Genetic and Gene-Environment Interaction Effects , 2011, Human Heredity.

[50]  V. Vaccarino,et al.  Heritability and seasonal variability of vitamin D concentrations in male twins. , 2010, The American journal of clinical nutrition.

[51]  Daniel L. Koller,et al.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study , 2010, The Lancet.

[52]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[53]  C. Gieger,et al.  Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior , 2010, Nature Genetics.

[54]  William Wheeler,et al.  Genome-wide association study of circulating vitamin D levels , 2010, Human molecular genetics.

[55]  P. Deloukas,et al.  Multiple common variants for celiac disease influencing immune gene expression , 2010, Nature Genetics.

[56]  C. Gieger,et al.  Sequence variants at CHRNB 3 – CHRNA 6 and CYP 2 A 6 affect smoking behavior , 2010 .

[57]  D. Eyles,et al.  Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases , 2009, Psychoneuroendocrinology.

[58]  J. Moan,et al.  The dependency of vitamin D status on body mass index, gender, age and season. , 2009, Anticancer research.

[59]  Xiping Xu,et al.  Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent twins. , 2009, The Journal of clinical endocrinology and metabolism.

[60]  A. Morris,et al.  Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis , 2008, The American journal of clinical nutrition.

[61]  J. Christopher Fromme,et al.  Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking , 2006, Nature Genetics.

[62]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[63]  T. Spector,et al.  Genetic Contribution to Bone Metabolism, Calcium Excretion, and Vitamin D and Parathyroid Hormone Regulation , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  D. Karasik,et al.  Statistical genetic analysis of plasma levels of vitamin D: familial study , 1999, Annals of human genetics.