The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans
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[1] R. Wiseman,et al. Brca2‐Null Embryonic Survival is Prolonged on the BALB/c Genetic Background , 2000, Molecular Carcinogenesis.
[2] Yudong D. He,et al. Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.
[3] Douglas F Easton,et al. BRCA1 and BRCA2 mutations in a population-based study of male breast cancer , 2001, Breast Cancer Research.
[4] Jong-Soo Lee,et al. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response , 2000, Nature.
[5] C. Begg. On the use of familial aggregation in population-based case probands for calculating penetrance. , 2002, Journal of the National Cancer Institute.
[6] Sandra J Shin,et al. Solid Variant of Mammary Adenoid Cystic Carcinoma With Basaloid Features: A Study of Nine Cases , 2002, The American journal of surgical pathology.
[7] A. Berns,et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer , 2001, Nature Genetics.
[8] F. Couch,et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. , 1998, Molecular cell.
[9] Douglas F Easton,et al. Cancer Incidence in BRCA1 mutation carriers. , 2002, Journal of the National Cancer Institute.
[10] M. J. van de Vijver,et al. The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] J. Peto,et al. p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours , 1998, Oncogene.
[12] C. Barlow,et al. Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice. , 2001, Carcinogenesis.
[13] M. Jasin,et al. BRCA2 is required for homology-directed repair of chromosomal breaks. , 2001, Molecular cell.
[14] K S Panageas,et al. Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[15] C. Deng,et al. A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability , 1998, Oncogene.
[16] T. Mak,et al. Animal models of tumor-suppressor genes. , 2001, Annual review of genetics.
[17] C. Deng,et al. Knockout mouse models and mammary tumorigenesis. , 2001, Seminars in cancer biology.
[18] Yonghong Xiao,et al. Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells , 1997, Cell.
[19] A. Monteiro,et al. Participation of BRCA1 in DNA Repair Response...Via Transcription , 2002, Cancer biology & therapy.
[20] W. El-Deiry,et al. BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets , 2002, Molecular and Cellular Biology.
[21] K A McAllister,et al. Mammary Tumor Induction and Premature Ovarian Failure in ApcMin Mice Are Not Enhanced by Brca2 Defi ciency , 2001, Toxicologic pathology.
[22] F. Kittrell,et al. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. , 2000, The American journal of pathology.
[23] M. King,et al. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. , 2001, Human molecular genetics.
[24] Thomas Ludwig,et al. Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice , 2001, Oncogene.
[25] M. King,et al. Linkage of early-onset familial breast cancer to chromosome 17q21. , 1990, Science.
[26] C. Deng,et al. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer , 2002, Oncogene.
[27] C. Deng. Roles of BRCA1 in centrosome duplication , 2002, Oncogene.
[28] L. Donehower,et al. Environmental carcinogens and p53 tumor‐suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis , 2002, Environmental and molecular mutagenesis.
[29] A. Ashworth,et al. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification , 1999, Current Biology.
[30] S. Seal,et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. , 1994, Science.
[31] X. Wang,et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. , 1999, Molecular cell.
[32] S C West,et al. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. , 2001, Molecular cell.
[33] S. Eisenberg,et al. A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[34] V. Godfrey,et al. Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice , 1999, Molecular and Cellular Biology.
[35] M. King,et al. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[36] Thomas Ludwig,et al. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity. , 2002, Current opinion in genetics & development.
[37] C. Liu,et al. Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. , 1996, Genes & development.
[38] C. Deng,et al. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice , 2001, Oncogene.
[39] S. Elledge,et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. , 2000, Genes & development.
[40] J. Rossant,et al. The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse , 1996, Cell.
[41] S. Elledge,et al. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. , 1999, Science.
[42] T. Julian,et al. Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers. , 2001, Cytometry.
[43] Steven E. Bayer,et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.
[44] H. Olsson. Cancer risks in BRCA2 mutation carriers. , 1999, Journal of the National Cancer Institute.
[45] Lawrence C. Brody,et al. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage , 2002, Nature Genetics.
[46] P. Chappuis,et al. TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution. , 2001, Cancer research.
[47] Christos Sotiriou,et al. Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers. , 2002, Journal of the National Cancer Institute.
[48] B. Koller,et al. Brca1 controls homology-directed DNA repair. , 1999, Molecular cell.
[49] P. Devilee,et al. A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage , 2001, Oncogene.
[50] T. Mak,et al. Brca1 required for T cell lineage development but not TCR loci rearrangement , 2000, Nature Immunology.
[51] G. Eichele,et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 , 1997, Nature.
[52] B. Koller,et al. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities , 1996, Nature Genetics.
[53] A. Ashworth,et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation , 1997, Nature Genetics.
[54] A. Ashworth,et al. Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation , 2002, EMBO reports.
[55] S. Gruber,et al. Cancer risks in BRCA1 carriers: time for the next generation of studies. , 2002, Journal of the National Cancer Institute.
[56] Thomas Ried,et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation , 1999, Nature Genetics.
[57] G. G. Stokes. "J." , 1890, The New Yale Book of Quotations.
[58] S. Lakhani,et al. CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation , 2001, British Journal of Cancer.
[59] E. Dougherty,et al. Gene-expression profiles in hereditary breast cancer. , 2001, The New England journal of medicine.
[60] Curtis C. Harris,et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis , 2001, Nature Genetics.
[61] T. Ludwig,et al. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. , 1997, Genes & development.
[62] T. Ludwig,et al. Tumorigenesis in mice carrying a truncating Brca1 mutation. , 2001, Genes & development.
[63] B. Rosen,et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. , 2001, American journal of human genetics.
[64] Bo Xu,et al. Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation , 2001, Molecular and Cellular Biology.
[65] B. Gusterson,et al. Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions , 1999, Oncogene.