The Ubiquitin System, Autophagy, and Regulated Protein Degradation.

This brief disquisition about the early history of studies on regulated protein degradation introduces several detailed reviews about the ubiquitin system and autophagy.

[1]  W. Tansey,et al.  Proteolytic control of the oncoprotein transcription factor Myc. , 2011, Advances in cancer research.

[2]  A. Varshavsky.  The N‐end rule pathway and regulation by proteolysis , 2011, Protein science : a publication of the Protein Society.

[3]  F. Wellmer,et al.  The plant N-end rule pathway: structure and functions. , 2010, Trends in plant science.

[4]  Ronald T. Hay,et al.  An additional role for SUMO in ubiquitin-mediated proteolysis , 2009, Nature Reviews Molecular Cell Biology.

[5]  Danny T. Huang,et al.  Structural insights into the catalysis and regulation of E3 ubiquitin ligases , 2016, Nature Reviews Molecular Cell Biology.

[6]  Alexander Varshavsky,et al.  An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes , 2017, Science.

[7]  N. Zheng,et al.  Ubiquitin Ligases: Structure, Function, and Regulation. , 2017, Annual review of biochemistry.

[8]  R. Fahlman,et al.  The-N-End Rule: The Beginning Determines the End. , 2016, Protein Peptide Letters.

[9]  S. Jentsch,et al.  Principles of ubiquitin and SUMO modifications in DNA repair , 2009, Nature.

[10]  W. Tansey,et al.  Damage control: DNA repair, transcription, and the ubiquitin-proteasome system. , 2009, DNA repair.

[11]  Xiaodong Huang,et al.  Drugging the undruggables: exploring the ubiquitin system for drug development , 2016, Cell Research.

[12]  B. Schulman,et al.  Twists and turns in ubiquitin‐like protein conjugation cascades , 2011, Protein science : a publication of the Protein Society.

[13]  A. Varshavsky.  The early history of the ubiquitin field , 2006, Protein science : a publication of the Protein Society.

[14]  I. Dikic,et al.  Bacteria-host relationship: ubiquitin ligases as weapons of invasion , 2016, Cell Research.

[15]  F. Förster,et al.  Unveiling the long-held secrets of the 26S proteasome. , 2013, Structure.

[16]  A Ciechanover,et al.  Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[17]  D. Komander,et al.  Mechanisms of Deubiquitinase Specificity and Regulation. , 2017, Annual review of biochemistry.

[18]  I. Dikič.  Proteasomal and Autophagic Degradation Systems. , 2017, Annual review of biochemistry.

[19]  Thomas Sommer,et al.  The Ubiquitin–Proteasome System of Saccharomyces cerevisiae , 2012, Genetics.

[20]  A. Varshavsky.  Naming a targeting signal , 1991, Cell.

[21]  P. Brzovic,et al.  Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases* , 2015, The Journal of Biological Chemistry.

[22]  A. Ciechanover,et al.  The ubiquitin-proteasome system and autophagy: Coordinated and independent activities. , 2016, The international journal of biochemistry & cell biology.

[23]  Ivan Dikic,et al.  Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins. , 2009, Chemical reviews.

[24]  A. Ciechanover,et al.  N-terminal Arginylation Targets Endoplasmic Reticulum Chaperone BiP to Autophagy Through p62 Binding , 2015, Nature Cell Biology.

[25]  J. Brodsky,et al.  The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation. , 2017, The Biochemical journal.

[26]  K. Truscott,et al.  The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases. , 2012, Biochimica et biophysica acta.

[27]  Yong Tae Kwon,et al.  The N-end rule pathway. , 2012, Annual review of biochemistry.

[28]  H. Ulrich,et al.  Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress , 2016, Front. Genet..

[29]  D. Finley,et al.  Gates, Channels, and Switches: Elements of the Proteasome Machine. , 2016, Trends in biochemical sciences.

[30]  Klaus Schulten,et al.  Structure of the human 26S proteasome at a resolution of 3.9 Å , 2016, Proceedings of the National Academy of Sciences.

[31]  Ivan Dikic,et al.  Ubiquitination in disease pathogenesis and treatment , 2014, Nature Medicine.

[32]  M. Hochstrasser,et al.  Origin and function of ubiquitin-like proteins , 2009, Nature.

[33]  M. Rapé,et al.  The increasing complexity of the ubiquitin code , 2016, Nature Cell Biology.

[34]  J Wade Harper,et al.  Quantifying ubiquitin signaling. , 2015, Molecular cell.

[35]  Alexander Varshavsky,et al.  N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals , 2010, Science.

[36]  J. Bacardit,et al.  The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions. , 2014, Trends in cell biology.

[37]  Y. Ohsumi.  Historical landmarks of autophagy research , 2013, Cell Research.

[38]  Bernd Bukau,et al.  The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies. , 2007, Trends in cell biology.

[39]  Alexander Varshavsky,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[40]  J. Huibregtse,et al.  Ubiquitination of newly synthesized proteins at the ribosome. , 2015, Biochimie.

[41]  Youdong Mao,et al.  Structural basis for dynamic regulation of the human 26S proteasome , 2016, Proceedings of the National Academy of Sciences.

[42]  R. Deshaies,et al.  Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy , 2014, BMC Biology.

[43]  A. Varshavsky.  Discovery of Cellular Regulation by Protein Degradation , 2008, Journal of Biological Chemistry.

[44]  J. Hurley,et al.  Mechanisms of Autophagy Initiation. , 2017, Annual review of biochemistry.

[45]  L. Aravind,et al.  Structure and evolution of ubiquitin and ubiquitin-related domains. , 2012, Methods in molecular biology.

[46]  R. Dohmen,et al.  Catalytic mechanism and assembly of the proteasome. , 2009, Chemical reviews.