Recent advances in the brain imaging of social anxiety disorder

Social anxiety disorder (SAD) is one of the most common and disabling anxiety disorders, yet much remains to be learned about its psychobiology. Although functional imaging has emphasized the role of the amygdala and other limbic structures in the neurobiology of SAD, structural and connectivity imaging techniques have emphasized the possibility of abnormalities in other regions and in whole‐brain networks. The involvement of a broad range of networks in SAD is consistent with current understandings of the neuroanatomy of emotion and of social processing. Copyright © 2012 John Wiley & Sons, Ltd.

[1]  P. Dechent,et al.  Reduced amygdalar and hippocampal size in adults with generalized social phobia. , 2010, Journal of psychiatry & neuroscience : JPN.

[2]  Patrick Dupont,et al.  Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram , 2010, Metabolic Brain Disease.

[3]  Daniel A. Fitzgerald,et al.  Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: A 4-Tesla functional MRI study , 2007, Psychiatry Research: Neuroimaging.

[4]  E. Skinhøj,et al.  Cerebral blood-flow. , 1972 .

[5]  N. Canteras,et al.  Neuroanatomy of anxiety. , 2010, Current topics in behavioral neurosciences.

[6]  L. Jäncke,et al.  White matter alterations in social anxiety disorder. , 2011, Journal of psychiatric research.

[7]  J. Haxby,et al.  Beyond amygdala: Default Mode Network activity differs between patients with Social Phobia and healthy controls , 2009, Brain Research Bulletin.

[8]  Clarissa Trzesniak,et al.  Neuroimaging in social anxiety disorder: A systematic review of the literature , 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[9]  C. Dalmaz,et al.  Oxidative imbalance and anxiety disorders. , 2014 .

[10]  Thomas Straube,et al.  Task-dependent neural correlates of the processing of verbal threat-related stimuli in social phobia , 2010, Biological Psychology.

[11]  D. Pine,et al.  Atypical modulation of medial prefrontal cortex to self-referential comments in generalized social phobia , 2011, Psychiatry Research: Neuroimaging.

[12]  Mats Fredrikson,et al.  Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia , 2004, Neuroscience Letters.

[13]  Huafu Chen,et al.  Disrupted functional connectivity in social anxiety disorder: a resting-state fMRI study. , 2011, Magnetic resonance imaging.

[14]  D. J. Stein,et al.  Resting brain perfusion in social anxiety disorder: A voxel-wise whole brain comparison with healthy control subjects , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[15]  Huafu Chen,et al.  Regional homogeneity changes in social anxiety disorder: A resting-state fMRI study , 2011, Psychiatry Research: Neuroimaging.

[16]  Dan J Stein,et al.  Functional brain imaging and pharmacotherapy in social phobia: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram , 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[17]  Wei Zhang,et al.  Selective aberrant functional connectivity of resting state networks in social anxiety disorder , 2010, NeuroImage.

[18]  Martin P Paulus,et al.  Influence of RGS2 on anxiety-related temperament, personality, and brain function. , 2008, Archives of general psychiatry.

[19]  Israel Liberzon,et al.  Preliminary Evidence of White Matter Abnormality in the Uncinate Fasciculus in Generalized Social Anxiety Disorder , 2009, Biological Psychiatry.

[20]  D. Stein,et al.  Grey matter abnormalities in social anxiety disorder: a pilot study , 2012, Metabolic Brain Disease.

[21]  Dan J Stein,et al.  The neuropsychiatry and neuropsychology of lipoid proteinosis. , 2008, The Journal of neuropsychiatry and clinical neurosciences.

[22]  Monique Ernst,et al.  Amygdala Function and 5-HTT Gene Variants in Adolescent Anxiety and Major Depressive Disorder , 2009, Biological Psychiatry.

[23]  T. Furmark,et al.  Size and burden of social phobia in Europe , 2005, European Neuropsychopharmacology.

[24]  S. Rombouts,et al.  Resting-state functional connectivity abnormalities in limbic and salience networks in social anxiety disorder without comorbidity , 2013, European Neuropsychopharmacology.

[25]  Philippe R Goldin,et al.  Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. , 2010, Emotion.

[26]  Heide Klumpp,et al.  Amygdala reactivity to faces at varying intensities of threat in generalized social phobia: An event-related functional MRI study , 2010, Psychiatry Research: Neuroimaging.

[27]  L. Jäncke,et al.  Evidence of frontotemporal structural hypoconnectivity in social anxiety disorder: A quantitative fiber tractography study , 2013, Human brain mapping.

[28]  Dan J Stein,et al.  Paradoxical Facilitation of Working Memory after Basolateral Amygdala Damage , 2012, PloS one.

[29]  Huafu Chen,et al.  Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder , 2011, Brain Research.

[30]  T. Furmark,et al.  Cerebral Blood Flow Changes After Treatment of Social Phobia with the Neurokinin-1 Antagonist GR205171, Citalopram, or Placebo , 2005, Biological Psychiatry.

[31]  Justin S. Feinstein,et al.  Fear Processing and Social Networking in the Absence of a Functional Amygdala , 2012, Biological Psychiatry.

[32]  Olga V. Demler,et al.  Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. , 2005, Archives of general psychiatry.

[33]  Pradeep J Nathan,et al.  Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. , 2009, Journal of psychiatry & neuroscience : JPN.

[34]  Darin D Dougherty,et al.  A PET Study of Tiagabine Treatment Implicates Ventral Medial Prefrontal Cortex in Generalized Social Anxiety Disorder , 2009, Neuropsychopharmacology.

[35]  T. Furmark,et al.  A Link between Serotonin-Related Gene Polymorphisms, Amygdala Activity, and Placebo-Induced Relief from Social Anxiety , 2008, The Journal of Neuroscience.

[36]  D. Stein,et al.  Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram , 2004, BMC psychiatry.

[37]  Ilya M. Veer,et al.  Neural sensitivity to social reward and punishment anticipation in social anxiety disorder , 2015, Front. Behav. Neurosci..

[38]  Wei Liao,et al.  Altered Effective Connectivity Network of the Amygdala in Social Anxiety Disorder: A Resting-State fMRI Study , 2010, PloS one.

[39]  T. Furmark,et al.  Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. , 2009, Journal of psychiatry & neuroscience : JPN.