Laminar flow velocity estimation by the use of narrow-band electronics with optical coherence tomography

Doppler optical coherence tomography (DOCT) technique is a new extension to the current OCT developments, that is capable of determining the frequency shift due to the moving scatterers, making it possible to map out the localised blood flows and vessels beneath tissue surface. Doppler OCT system, being employed with a broadband detection electronics to measure frequency shift, is more complex than a narrowband OCT system, because a follow up filter is needed to overcome its low signal-to-noise ratio (SNR) for structure imaging. We describe a simple technique to estimate accurately the laminar flow velocity by the use of narrowband OCT system that is simpler and has a high SNR. It utilises the limited band of electronics to reconstruct the whole laminar velocity profile across target by the use of the least square curve fitting technique. The experimental results demonstrate that the estimated velocity profile by using this method correlate very well with the theoretical predictions. It may, therefore, allow the simpler OCT system to determine the flow velocity functionally in a simple and economic way for monitoring blood flow in vivo.

[1]  M. V. van Gemert,et al.  Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. , 1997, Optics letters.

[2]  P ? ? ? ? ? ? ? % ? ? ? ? , 1991 .

[3]  J. Fujimoto,et al.  In vivo ultrahigh-resolution optical coherence tomography. , 1999, Optics letters.

[4]  T G van Leeuwen,et al.  High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography. , 1999, Optics letters.

[5]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[6]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[7]  L L Otis,et al.  Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. , 1998, Applied optics.

[8]  J. Izatt,et al.  High-resolution cross-sectional imaging of the gastrointestinal tract using optical coherence tomography: preliminary results. , 1998, Gastrointestinal endoscopy.

[9]  J M Schmitt,et al.  Subsurface imaging of living skin with optical coherence microscopy. , 1995, Dermatology.

[10]  J. Fujimoto,et al.  In vivo retinal imaging by optical coherence tomography. , 1993, Optics letters.

[11]  Ruikang K. Wang,et al.  Propylene glycol as a contrasting agent for optical coherence tomography to image gastrointestinal tissues , 2002, Lasers in surgery and medicine.

[12]  G. Hutchins,et al.  Correlation between wall shear and intimal thickness at a coronary artery branch. , 1987, Atherosclerosis.

[13]  Liu Wu Simultaneous measurement of flow velocity and Doppler angle by the use of Doppler optical coherence tomography , 2004 .

[14]  J B Fitzgerald,et al.  Real-time detection technique for Doppler optical coherence tomography. , 2000, Optics letters.

[15]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[16]  Valery V. Tuchin,et al.  Concurrent enhancement of imaging depth and contrast for optical coherence tomography by hyperosmotic agents , 2001 .

[17]  Zhongping Chen,et al.  Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media. , 1997, Optics letters.

[18]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[19]  J. Fujimoto,et al.  Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. , 2000, Neoplasia.

[20]  J. Nelson,et al.  Measurement of fluid-flow-velocity profile in turbid media by the use of optical Doppler tomography. , 1997, Applied optics.

[21]  J. D. de Boer,et al.  Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow. , 2000, Optics letters.

[22]  J. Izatt,et al.  Optimal interferometer designs for optical coherence tomography. , 1999, Optics letters.

[23]  E A Swanson,et al.  Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. , 1994, Archives of ophthalmology.

[24]  Siavash Yazdanfar,et al.  Real-time, high velocity-resolution color Doppler optical coherence tomography. , 2002, Optics letters.

[25]  P. Serruys,et al.  Evaluation of endothelial shear stress and 3D geometry as factors determining the development of atherosclerosis and remodeling in human coronary arteries in vivo. Combining 3D reconstruction from angiography and IVUS (ANGUS) with computational fluid dynamics. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[26]  Zhongping Chen,et al.  Phase-resolved optical coherence tomography and optical Doppler tomography for imaging blood flow in human skin with fast scanning speed and high velocity sensitivity. , 2000, Optics letters.

[27]  George J. Hademenos THE BIOPHYSICS OF STROKE , 1997 .