Sequentially degradable hydrogel-microsphere loaded with doxorubicin and pioglitazone synergistically inhibits cancer stemness of osteosarcoma.

[1]  Yong Zhang,et al.  Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma , 2022, Journal of experimental & clinical cancer research : CR.

[2]  W. Ye,et al.  The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway , 2021, Acta pharmaceutica Sinica. B.

[3]  Z. Qian,et al.  Curcumin-Microsphere/IR820 Hybrid Bifunctional Hydrogels for In Situ Osteosarcoma Chemo-co-Thermal Therapy and Bone Reconstruction. , 2021, ACS applied materials & interfaces.

[4]  R. Haag,et al.  Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy , 2020, Advanced Functional Materials.

[5]  Jianru Xiao,et al.  Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges. , 2020, Biomaterials.

[6]  Xu Zhou,et al.  Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells , 2020, Science Advances.

[7]  A. Shamloo,et al.  Development of a polyvinyl alcohol/sodium alginate hydrogel-based scaffold incorporating bFGF-encapsulated microspheres for accelerated wound healing , 2020, Scientific Reports.

[8]  Wen Peng,et al.  Targeting cancer stem cell pathways for cancer therapy , 2020, Signal Transduction and Targeted Therapy.

[9]  M. Najafi,et al.  Cancer stem cell (CSC) resistance drivers. , 2019, Life sciences.

[10]  N. Yamamoto,et al.  Pioglitazone, an agonist of PPARγ, reverses doxorubicin-resistance in an osteosarcoma patient-derived orthotopic xenograft model by downregulating P-glycoprotein expression. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  Peipei Xu,et al.  Overcoming Hypoxia by Multistage Nanoparticle Delivery System to Inhibit Mitochondrial Respiration for Photodynamic Therapy , 2019, Advanced Functional Materials.

[12]  Jie Luo,et al.  Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced tumor penetration. , 2018, Journal of colloid and interface science.

[13]  Xin Xiao,et al.  HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma , 2018, Journal of experimental & clinical cancer research : CR.

[14]  M. Ishida,et al.  Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell. , 2018, Molecular pharmaceutics.

[15]  Yang Ding,et al.  Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy , 2018, Nano Research.

[16]  R. G. Richards,et al.  Drug delivery systems functionalized with bone mineral seeking agents for bone targeted therapeutics , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[17]  V. Lewis,et al.  Current and future therapeutic approaches for osteosarcoma , 2018, Expert review of anticancer therapy.

[18]  H. Clevers,et al.  Cancer stem cells revisited , 2017, Nature Medicine.

[19]  Qiaojun He,et al.  Inhibition of KLF4 by Statins Reverses Adriamycin-Induced Metastasis and Cancer Stemness in Osteosarcoma Cells , 2017, Stem cell reports.

[20]  D. Heymann,et al.  Cancer stem cells in osteosarcoma. , 2017, Cancer letters.

[21]  Xuesi Chen,et al.  Injectable Hydrogel-Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy. , 2017, ACS applied materials & interfaces.

[22]  Zhen Gu,et al.  Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus , 2016, Advanced materials.

[23]  Fidel Ramírez,et al.  deepTools2: a next generation web server for deep-sequencing data analysis , 2016, Nucleic Acids Res..

[24]  M. Vallet‐Regí,et al.  Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues. , 2015, ACS applied materials & interfaces.

[25]  N. Syed,et al.  Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors , 2015, Molecular Cancer.

[26]  L. Mishra,et al.  EMT, CTCs and CSCs in tumor relapse and drug-resistance , 2015, Oncotarget.

[27]  X. Wang,et al.  Delivery of platinum(IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles. , 2014, Biomaterials.

[28]  R. Srinivas,et al.  Pioglitazone: A review of analytical methods , 2014, Journal of pharmaceutical analysis.

[29]  S. Ganta,et al.  Role of integrated cancer nanomedicine in overcoming drug resistance. , 2013, Advanced drug delivery reviews.

[30]  W. Tap,et al.  Long‐term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high‐grade, operable osteosarcoma , 2012, Cancer.

[31]  Christopher J. B. Nicol,et al.  PPAR Medicines and Human Disease: The ABCs of It All , 2012, PPAR research.

[32]  B. Cheirsilp,et al.  Production and properties of two collagenases from bacteria and their application for collagen extraction. , 2011, New biotechnology.

[33]  F. Papaccio,et al.  Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  R. Jain,et al.  Delivering nanomedicine to solid tumors , 2010, Nature Reviews Clinical Oncology.

[35]  Xian-Jun Qu,et al.  Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance. , 2008, Current medicinal chemistry.

[36]  R. Gorlick,et al.  Chemotherapy resistance in osteosarcoma: current challenges and future directions , 2006, Expert review of anticancer therapy.

[37]  Nicholas Denko,et al.  Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment , 2006, Molecular Cancer Research.

[38]  Kristian Pietras,et al.  High interstitial fluid pressure — an obstacle in cancer therapy , 2004, Nature Reviews Cancer.

[39]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[40]  Kinam Park,et al.  Environment-sensitive hydrogels for drug delivery. , 2001, Advanced drug delivery reviews.