Transcatheter vascular occlusion therapy with isobutyl 2-cyanoacrylate (bucrylate) for control of massive upper-gastrointestinal bleeding.

Transcatheter embolization with bucrylate, a tissue adhesive, was performed in 16 patients with massive upper-gastrointestinal bleeding. Control of arterial bleeding from the stomach was achieved in 6 of 8 patients, and from the duodenum in 3 of 4. Embolization of gastric veins resulted in temporary control of esophageal variceal bleeding in 3 of 4 patients. Histological study showed no evidence of bucrylate causing histotoxicity in 2 patients. Because bucrylate polymerizes rapidly, a localized vascular occlusion mimicking a surgical ligation is produced. Because collateral vessels are not occluded. localized tissue ischemia is unlikely. Tissue adhesives are, however, difficult to use.

[1]  M. Viamonte,et al.  Pitfalls in transhepatic portography. , 1977, Radiology.

[2]  M. Viamonte,et al.  New techniques for interruption of gastroesophageal venous blood flow. , 1977, Radiology.

[3]  L. Adelman,et al.  Spinal cord infarction following therapeutic renal artery embolization. , 1977, JAMA.

[4]  Z. Braf,et al.  Gangrene of bladder. Complication of hypogastric artery embolization. , 1977, Urology.

[5]  J. Kattwinkel,et al.  Renal infarction: a complication of gelfoam embolization of a hemangioendothelioma of the liver. , 1977, AJR. American journal of roentgenology.

[6]  M. Wholey,et al.  Bronchial artery embolization for massive hemoptysis. , 1976, JAMA.

[7]  I. Beck,et al.  Atheromatous embolization to the stomach , 1976, The American journal of digestive diseases.

[8]  E. Bradley,et al.  Transcatheter therapeutic embolization in the management of massive upper gastrointestinal bleeding. , 1976, Radiology.

[9]  G. Simonetti,et al.  Transcatheter therapeutic arterial embolization. , 1976, Radiology.

[10]  J. Anderson,et al.  Transcatheter occlusion of abdominal tumors. , 1976, Radiology.

[11]  J. Doppman,et al.  Paraspinal muscle infarction. A painful complication of lumbar artery embolization associated with pathognomonic radiographic and laboratory findings. , 1976, Radiology.

[12]  J. Woodside,et al.  Peripheral embolization complicating bilateral renal infarction with gelfoam. , 1976, AJR. American journal of roentgenology.

[13]  Bradley Rd,et al.  Gastric infarction after therapeutic embolization. , 1976 .

[14]  M. Steer,et al.  The nonoperative treatment of massive pyloroduodenal hemorrhage by retracted autologous clot embolization. , 1976, Surgery.

[15]  R. Bree,et al.  Selective arterial embolization for control of massive upper gastrointestinal bleeding. , 1975, The American journal of roentgenology, radium therapy, and nuclear medicine.

[16]  J. Rösch,et al.  Experimental catheter obstruction of the gastric coronary vein. Possible technique for percutaneous intravascular tamponade of the gastroesophageal varices. , 1975, Investigative radiology.

[17]  J. Bookstein,et al.  Transcatheter hemostasis of gastrointestinal bleeding using modified autogenous clot. , 1974, Radiology.

[18]  J. Prochaska,et al.  Left gastric artery embolization for control of gastric bleeding: a complication. , 1973, Radiology.

[19]  E. Ring,et al.  Arteriography in the management of hemorrhage from pelvic fractures. , 1972, The New England journal of medicine.

[20]  R. Harvey,et al.  Infarction of the stomach following atheromatous embolization. Report of a case and literature review. , 1972, Gastroenterology.

[21]  J. Rösch,et al.  Selective arterial embolization. A new method for control of acute gastrointestinal bleeding. , 1972, Radiology.

[22]  U. Tylén,et al.  Follow-up of patients with portal hypertension and esophageal varices treated with percutaneous obliteration of gastric coronary vein. , 1977, Radiology.

[23]  J. Remy,et al.  Treatment of hemoptysis by embolization of bronchial arteries. , 1977, Radiology.

[24]  J. Rösch,et al.  Instant selective arterial occlusion with isobutyl 2-cyanoacrylate. , 1975, Radiology.

[25]  C. Kerber.  Experimental arteriovenous fistula. Creation and percutaneous catherter obstruction with cyanoacrylate. , 1975, Investigative radiology.