STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks
暂无分享,去创建一个
D. Holtzman | G. Zipfel | A. Bauer | I. Singh | Eunjae Lee | Deepti Diwan | James W. Nelson | J. Mehla | Molly Lawrence
[1] D. Attwell,et al. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease , 2020, Acta Neuropathologica.
[2] 2020 Alzheimer's disease facts and figures , 2020, Alzheimer's & dementia : the journal of the Alzheimer's Association.
[3] R. Sperling,et al. Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways , 2019, Nature Reviews Neurology.
[4] H. Dodt,et al. Early Aβ reduction prevents progression of cerebral amyloid angiopathy , 2019, Annals of neurology.
[5] D. Holtzman,et al. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies , 2019, Cell.
[6] A. Halle,et al. Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model , 2019, EMBO molecular medicine.
[7] Adam Q. Bauer,et al. Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components , 2018, Neurobiology of Disease.
[8] Publisher's Note , 2018, Anaesthesia.
[9] L. Carey,et al. Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke , 2017, NeuroImage: Clinical.
[10] Sun Mi Gu,et al. (E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway , 2017, NeuroMolecular Medicine.
[11] G. Bu,et al. Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies , 2017, Journal of Lipid Research.
[12] Yuka Kanno,et al. Mechanisms and consequences of Jak–STAT signaling in the immune system , 2017, Nature Immunology.
[13] Eric E. Smith,et al. Cerebral Amyloid Angiopathy Is Associated With Executive Dysfunction and Mild Cognitive Impairment , 2016, Stroke.
[14] G. Bu,et al. Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells , 2016, Molecular Neurodegeneration.
[15] D. Peebles,et al. Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic‐ischaemic brain damage , 2016, Journal of neurochemistry.
[16] D. Holtzman,et al. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models , 2015, Acta neuropathologica communications.
[17] J. Schneider,et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease , 2015, Alzheimer's & Dementia.
[18] Rena Li,et al. Chronic Anatabine Treatment Reduces Alzheimer’s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD , 2015, PloS one.
[19] D. Houitte,et al. The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases , 2015, The Journal of Neuroscience.
[20] D. Holtzman,et al. Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice , 2015, Proceedings of the National Academy of Sciences.
[21] B. Maras,et al. Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid , 2015, Neurochemistry International.
[22] Abraham Z. Snyder,et al. Optical imaging of disrupted functional connectivity following ischemic stroke in mice , 2014, NeuroImage.
[23] R. Hammer,et al. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow , 2014, Molecular Neurodegeneration.
[24] Hong Jiang,et al. Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis , 2014, The Journal of Neuroscience.
[25] G. Bu,et al. The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease , 2014, Front. Aging Neurosci..
[26] B. Hutter-Paier,et al. Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer’s disease , 2014, Journal of Neuroinflammation.
[27] S. Itohara,et al. Single App knock-in mouse models of Alzheimer's disease , 2014, Nature Neuroscience.
[28] Sean M. Riordan,et al. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase , 2014, Molecular Neurodegeneration.
[29] Jialin C. Zheng,et al. A novel role of the STAT3 pathway in brain inflammation-induced human neural progenitor cell differentiation. , 2013, Current molecular medicine.
[30] Christina Chan,et al. Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes , 2013, Experimental Neurology.
[31] S. Zhuang. Regulation of STAT signaling by acetylation. , 2013, Cellular signalling.
[32] R. Deane,et al. Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance , 2013, Proceedings of the National Academy of Sciences.
[33] F. Faraci,et al. Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension , 2013, Hypertension.
[34] M. Verma,et al. Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation. , 2013, European journal of pharmacology.
[35] Nathan T. Ross,et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. , 2012, The Journal of clinical investigation.
[36] Max A Viergever,et al. Extent of Bilateral Neuronal Network Reorganization and Functional Recovery in Relation to Stroke Severity , 2012, The Journal of Neuroscience.
[37] Adam W. Bero,et al. Bidirectional Relationship between Functional Connectivity and Amyloid-β Deposition in Mouse Brain , 2012, The Journal of Neuroscience.
[38] L. Harrington,et al. Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation , 2012, Proceedings of the National Academy of Sciences.
[39] Jacob K. Greenberg,et al. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy , 2011, Molecular Neurodegeneration.
[40] Xue-feng Wang,et al. Role of Signal Transducer and Activator of Transcription-3 in Up-Regulation of GFAP After Epilepsy , 2011, Neurochemical Research.
[41] M. Raichle,et al. Resting-state activity in development and maintenance of normal brain function , 2011, Proceedings of the National Academy of Sciences.
[42] Abraham Z. Snyder,et al. Imaging of Functional Connectivity in the Mouse Brain , 2011, PloS one.
[43] O. Riess,et al. Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease , 2011, Molecular Neurodegeneration.
[44] D. Butterfield,et al. Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. , 2010, Free radical biology & medicine.
[45] Zhenguo Wu,et al. Tyk2/STAT3 Signaling Mediates β-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease , 2010, The Journal of Neuroscience.
[46] N. Durany,et al. Oxidative stress in Alzheimer disease , 2009, Cell adhesion & migration.
[47] X. Niu,et al. Leukocyte Antigen-related Protein Tyrosine Phosphatase Negatively Regulates Hydrogen Peroxide-induced Vascular Smooth Muscle Cell Apoptosis* , 2008, Journal of Biological Chemistry.
[48] Y. Hanakawa,et al. Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[49] Biyu J. He,et al. Electrophysiological correlates of the brain's intrinsic large-scale functional architecture , 2008, Proceedings of the National Academy of Sciences.
[50] J. Provias,et al. Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis. , 2008, Current Alzheimer research.
[51] S. Akira,et al. STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury , 2008, The Journal of Neuroscience.
[52] X. Tong,et al. Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease , 2008, Experimental physiology.
[53] Clara A. Scholl,et al. Synchronized delta oscillations correlate with the resting-state functional MRI signal , 2007, Proceedings of the National Academy of Sciences.
[54] S. Matsuda,et al. Microglia‐derived interleukin‐6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells , 2007, The European journal of neuroscience.
[55] B. Sakmann,et al. Phase-locking of hippocampal interneurons' membrane potential to neocortical up-down states , 2006, Nature Neuroscience.
[56] Hideyuki Okano,et al. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury , 2006, Nature Medicine.
[57] X. Tong,et al. Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. , 2005, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[58] Maurizio Corbetta,et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[59] C. Iadecola. Neurovascular regulation in the normal brain and in Alzheimer's disease , 2004, Nature Reviews Neuroscience.
[60] A. Nunomura,et al. Oxidative Damage Is the Earliest Event in Alzheimer Disease , 2001, Journal of neuropathology and experimental neurology.
[61] J. Ihle. The Stat family in cytokine signaling. , 2001, Current opinion in cell biology.
[62] C. Justicia,et al. Activation of the JAK/STAT pathway following transient focal cerebral ischemia: Signaling through Jak1 and Stat3 in astrocytes , 2000, Glia.
[63] M. Ross,et al. Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex , 2000, The Journal of Neuroscience.
[64] R. El Bekay,et al. Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes* , 1999, The Journal of Biological Chemistry.
[65] S. Younkin,et al. Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.
[66] M. Raichle,et al. Disease and the brain's dark energy , 2010, Nature Reviews Neurology.
[67] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[68] R. Deacon. Burrowing in rodents: a sensitive method for detecting behavioral dysfunction , 2006, Nature Protocols.