Visualization of microvascularity in glioblastoma multiforme with 8-T high-spatial-resolution MR imaging.

We used 8-T high-spatial-resolution gradient-echo MR imaging to directly visualize microvascularity in pathologically proved glioblastoma multiforme. Images were compared with 1.5-T high-spatial-resolution fast spin-echo T2-weighted images and digital subtraction angiograms. Preliminary data indicate that 8-T high-spatial-resolution MR imaging may enable the identification of areas of abnormal microvascularity in glioblastoma multiforme that are not visible with other routine clinical techniques.

[1]  M. Neeman,et al.  Neovascularization induced growth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging. , 1995, Cancer research.

[2]  P. Robitaille,et al.  Macroscopic susceptibility in ultra high field MRI. , 1999, Journal of computer assisted tomography.

[3]  M. Neeman,et al.  Stimulation of tumour angiogenesis by proximal wounds: spatial and temporal analysis by MRI. , 1998, British Journal of Cancer.

[4]  N. Weidner,et al.  Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow , 1998, The Journal of pathology.

[5]  A. Kangarlu,et al.  Human leptomeningeal and cortical vascular anatomy of the cerebral cortex at 8 Tesla. , 1999, Journal of computer assisted tomography.

[6]  R. Goebel,et al.  7T vs. 4T: RF power, homogeneity, and signal‐to‐noise comparison in head images , 2001, Magnetic resonance in medicine.

[7]  J. Folkman,et al.  Tumor angiogenesis: a quantitative method for histologic grading. , 1972, Journal of the National Cancer Institute.

[8]  H. Augustin,et al.  Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. , 2000, Cancer research.

[9]  A. Kangarlu,et al.  Macroscopic susceptibility in ultra high field MRI. II: acquisition of spin echo images from the human head. , 1999, Journal of computer assisted tomography.

[10]  Webster K. Cavenee,et al.  Pathology and genetics of tumours of the nervous system. , 2000 .

[11]  A. Kangarlu,et al.  High resolution MRI of the deep brain vascular anatomy at 8 Tesla: susceptibility-based enhancement of the venous structures. , 1999, Journal of computer assisted tomography.

[12]  M. Neeman Preclinical MRI Experience in Imaging Angiogenesis , 2004, Cancer and Metastasis Reviews.

[13]  B. Wolf,et al.  VEINS OF THE WHITE MATTER OF THE CEREBRAL HEMISPHERES (THE MEDULLARY VEINS). , 1964, The American journal of roentgenology, radium therapy, and nuclear medicine.