[A systematic review of using myorelaxants in treatment of low back pain].

A systematic review summarizes the results of studies on the efficacy of myorelaxants (tolperisone, tizanidine, thiocolchicoside or baclofen) in the treatment of acute nonspecific low back pain published up to Dec. 2017. The authors conclude that there are enough data to confirm the efficacy of myorelaxants in treatment of nonspecific low back pain, myorelaxants are recommended as monotherapy or in combination with analgesics or NSAID, the nonsedative drugs tolperisone or thiocolchicoside should be preferred.

[1]  Timothy J Wilt,et al.  Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. , 2017, Annals of internal medicine.

[2]  Kylie A. Williams,et al.  Efficacy and tolerability of muscle relaxants for low back pain: Systematic review and meta‐analysis , 2017, European journal of pain.

[3]  B. Koes,et al.  Red flags presented in current low back pain guidelines: a review , 2016, European Spine Journal.

[4]  S. Chatterji,et al.  Risk Factors and Disability Associated with Low Back Pain in Older Adults in Low- and Middle-Income Countries. Results from the WHO Study on Global AGEing and Adult Health (SAGE) , 2015, PloS one.

[5]  Gail M. Williams,et al.  A systematic review of the global prevalence of low back pain. , 2012, Arthritis and rheumatism.

[6]  A. Biswas,et al.  Effectiveness of Tolperisone Hydrochloride with Aceclofenac as Combined Therapy in Acute Low Back Pain. , 2012 .

[7]  P. Kotwal,et al.  Clinical Comparative Study: Efficacy and Tolerability of Tolperisone and Thiocolchicoside in Acute Low Back Pain and Spinal Muscle Spasticity , 2012, Asian spine journal.

[8]  B. Casazza.  Diagnosis and treatment of acute low back pain. , 2012, American family physician.

[9]  Martin Underwood,et al.  Non-specific low back pain , 2012, The Lancet.

[10]  P. Hodges,et al.  Moving differently in pain: A new theory to explain the adaptation to pain , 2011, PAIN.

[11]  L. Macedo,et al.  An updated overview of clinical guidelines for the management of non-specific low back pain in primary care , 2010, European Spine Journal.

[12]  C. Maher,et al.  How do we define the condition ‘recurrent low back pain’? A systematic review , 2010, European Spine Journal.

[13]  Anil Gupta,et al.  Aceclofenac–tizanidine in the treatment of acute low back pain: a double-blind, double-dummy, randomized, multicentric, comparative study against aceclofenac alone , 2009, European Spine Journal.

[14]  D. Soonawalla,et al.  Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. , 2008, Journal of the Indian Medical Association.

[15]  M. Friedrich.  Evidenz- und konsensusbasierte österreichische Leitlinien für das Management akuter und chronischer unspezifischer Kreuzschmerzen , 2007, Wiener klinische Wochenschrift.

[16]  J. Katz,et al.  Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. , 2006, The Journal of bone and joint surgery. American volume.

[17]  S. Karamursel,et al.  Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain , 2005, International journal of clinical practice.

[18]  E. Montané,et al.  Oral antispastic drugs in nonprogressive neurologic diseases , 2004, Neurology.

[19]  Roger Chou,et al.  Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. , 2004, Journal of pain and symptom management.

[20]  L M Bouter,et al.  Muscle relaxants for non-specific low back pain. , 2003, The Cochrane database of systematic reviews.

[21]  B. Kuran,et al.  Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. , 2003, Joint, bone, spine : revue du rhumatisme.

[22]  G. Abbruzzese.  The medical management of spasticity. , 2002, European journal of neurology.

[23]  F. Horvath,et al.  Evaluation of sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, randomized, double-blind, placebo-controlled trial. , 1998, Pharmacopsychiatry.

[24]  R. Alken,et al.  Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial , 1996, Pain.

[25]  M. Scheinin,et al.  The Sedative and Sympatholytic Effects of Oral Tizanidine in Healthy Volunteers , 1996, Anesthesia and analgesia.

[26]  M. J. Klein,et al.  Effects of acute and repeated doses of two muscle relaxants chlormezanone and thiocolchicoside, on vigilance and psychomotor performance of healthy volunteers , 1991 .

[27]  M. Revel,et al.  [Evaluation of thiocolchicoside as monotherapy in low back pain. Results of a randomized study versus placebo]. , 1990, Presse medicale.

[28]  H. Berry,et al.  Tizanidine and Ibuprofen in Acute Low-Back Pain: Results of a Double-Blind Multicentre Study in General Practice , 1988, The Journal of international medical research.

[29]  H. Berry,et al.  A Multicentre Placebo-Controlled Study in General Practice to Evaluate the Efficacy and Safety of Tizanidine in Acute Low-Back Pain , 1988, The Journal of international medical research.

[30]  M O Roland,et al.  A critical review of the evidence for a pain-spasm-pain cycle in spinal disorders. , 1986, Clinical biomechanics.

[31]  B. Northrup,et al.  Baclofen for the Treatment of Acute Low-Back Syndrome: A Double-Blind Comparison with Placebo , 1985, Spine.

[32]  A. Guekht,et al.  [Results of a randomized double blind parallel study on the efficacy and safety of tolpersione in patients with acute nonspecific low back pain]. , 2017, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.

[33]  H. Brisby.  Pain Origin and Mechanisms in Low Back Pain , 2016 .

[34]  J. Caro,et al.  A systematic review of low back pain cost of illness studies in the United States and internationally. , 2008, The spine journal : official journal of the North American Spine Society.

[35]  D. Streiner,et al.  Sleep and quality of life in clinical medicine , 2008 .

[36]  B. Koes,et al.  On behalf of the COST B13 Working Group on Guidelines for the Management of Acute Low Back Pain in Primary Care. , 2006 .

[37]  A. Woolf,et al.  Burden of major musculoskeletal conditions. , 2003, Bulletin of the World Health Organization.