Natural History of UCAs in Elderly Patients Prevalence of UCAs

The prevalence of unruptured cerebral aneurysms (UCAs) in elderly patients is increasing in our aging population. UCA management in elderly patients has some difficulties, such as reduced life expectancy, increased comorbidities and treatment risks, and poor prognosis in case of rupture. In this review article, we summarize the most recent findings on the natural history, therapeutic options and treatment results for UCAs exclusively in elderly patients, and describe possible medical treatments for patients with UCAs.

[1]  M. Lawton,et al.  Comparison of clipping and coiling in elderly patients with unruptured cerebral aneurysms. , 2017, Journal of neurosurgery.

[2]  D. Kallmes,et al.  Age-related outcomes following intracranial aneurysm treatment with the Pipeline Embolization Device: a subgroup analysis of the IntrePED registry. , 2016, Journal of neurosurgery.

[3]  T. Kawada.  Risk of rupture of unruptured cerebral aneurysms in elderly patients , 2016, Neurology.

[4]  E. Connolly,et al.  International study of unruptured intracranial aneurysms. , 2014, Journal of neurosurgery.

[5]  Robert D. Brown,et al.  Age-related differences in unruptured intracranial aneurysms: 1-year outcomes. , 2014, Journal of neurosurgery.

[6]  A. Qureshi,et al.  Comparison of long-term outcomes associated with endovascular treatment vs surgical treatment among Medicare beneficiaries with unruptured intracranial aneurysms. , 2014, Neurosurgery.

[7]  T. Hishikawa,et al.  Cerebral Vasospasm in Patients over 80 Years Treated by Coil Embolization for Ruptured Cerebral Aneurysms , 2014, BioMed research international.

[8]  Bruno Lunenfeld,et al.  The clinical consequences of an ageing world and preventive strategies. , 2013, Best practice & research. Clinical obstetrics & gynaecology.

[9]  S. Juvela,et al.  Natural History of Unruptured Intracranial Aneurysms: A Long-term Follow-up Study , 2013, Stroke.

[10]  M. Ichinose,et al.  Prevalence of unruptured intracranial aneurysms in healthy asymptomatic Japanese adults: differences in gender and age , 2013, Acta Neurochirurgica.

[11]  J. Öhman,et al.  The connection between ruptured cerebral aneurysms and odontogenic bacteria , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[12]  David F. Kallmes,et al.  Endovascular Treatment of Intracranial Aneurysms With Flow Diverters: A Meta-Analysis , 2013, Stroke.

[13]  W. Koch,et al.  Biology of Intracranial Aneurysms: Role of Inflammation , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  S. Fukuhara,et al.  The natural course of unruptured cerebral aneurysms in a Japanese cohort. , 2012, The New England journal of medicine.

[15]  M. Tymianski.  Aspirin as a promising agent for decreasing incidence of cerebral aneurysm rupture. , 2011, Stroke.

[16]  A. Algra,et al.  Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis , 2011, The Lancet Neurology.

[17]  D. Kallmes,et al.  Effect of Age on Outcomes of Treatment of Unruptured Cerebral Aneurysms: A Study of the National Inpatient Sample 2001–2008 , 2011, Stroke.

[18]  M. Sonobe,et al.  Small Unruptured Intracranial Aneurysm Verification Study: SUAVe Study, Japan , 2010, Stroke.

[19]  HaruhikoKikuchi,et al.  Small Unruptured Intracranial Aneurysm Verification Study , 2010 .

[20]  A. Alshekhlee,et al.  Hospital Mortality and Complications of Electively Clipped or Coiled Unruptured Intracranial Aneurysm , 2010, Stroke.

[21]  T. Tominaga,et al.  Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats , 2010, Brain Research.

[22]  K. Nozaki,et al.  Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox−/− mice , 2009, Laboratory Investigation.

[23]  K. Nozaki,et al.  PITAVASTATIN SUPPRESSES FORMATION AND PROGRESSION OF CEREBRAL ANEURYSMS THROUGH INHIBITION OF THE NUCLEAR FACTOR κB PATHWAY , 2009, Neurosurgery.

[24]  Yuichi Murayama,et al.  Unruptured Intracranial Aneurysms: Incidence of Rupture and Risk Factors , 2009, Stroke.

[25]  Per Enblad,et al.  International Subarachnoid Aneurysm Trial of Neurosurgical Clipping Versus Endovascular Coiling: Subgroup Analysis of 278 Elderly Patients , 2008, Stroke.

[26]  K. Nozaki,et al.  Simvastatin Suppresses the Progression of Experimentally Induced Cerebral Aneurysms in Rats , 2008, Stroke.

[27]  Irene C van der Schaaf,et al.  Risk of Rupture of Unruptured Intracranial Aneurysms in Relation to Patient and Aneurysm Characteristics: An Updated Meta-Analysis , 2007, Stroke.

[28]  C. Ogilvy,et al.  Age-dependent Differences in Short-term Outcome after Surgical or Endovascular Treatment of Unruptured Intracranial Aneurysms in the United States, 1996–2000 , 2004, Neurosurgery.

[29]  D. Nichols,et al.  Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment , 2003, The Lancet.

[30]  Peter Sandercock,et al.  For Personal Use. Only Reproduce with Permission from the Lancet Publishing Group , 2022 .

[31]  M. Fujishima,et al.  Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study. , 1999, Stroke.

[32]  M. Murad,et al.  Endovascular Treatment of Intracranial Aneurysms in Elderly Patients , 2013 .

[33]  牧野 洋.  Pharmacological stabilization of intracranial aneurysms in mice : a feasibility study , 2013 .

[34]  C. Hong,et al.  Benefits of surgical treatment for unruptured intracranial aneurysms in elderly patients. , 2011, Journal of Korean Neurosurgical Society.