Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway

[1]  G. Montana,et al.  The Keap1 signaling in the regulation of HSP90 pathway , 2022, Cell Stress and Chaperones.

[2]  Y. Jia,et al.  Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway. , 2022, Food & function.

[3]  Qin M. Chen,et al.  Nrf2 Signaling in Heart Failure: Expression of Nrf2, Keap1, Antioxidant and Detoxification Genes in Dilated or Ischemic Cardiomyopathy. , 2022, Physiological genomics.

[4]  Yifei Liu,et al.  Nrf2 Promotes Inflammation in Early Myocardial Ischemia-Reperfusion via Recruitment and Activation of Macrophages , 2021, Frontiers in Immunology.

[5]  Tim Baldensperger,et al.  Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases , 2021, Redox biology.

[6]  I. Juric,et al.  Oxidative Stress in Ischemic Heart Disease , 2020, Oxidative medicine and cellular longevity.

[7]  Min Zhang,et al.  Inducible expression of heat shock protein 20 protects airway epithelial cells against oxidative injury involving the Nrf2-NQO-1 pathway , 2020, Cell & bioscience.

[8]  M. J. Hashim,et al.  Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study , 2020, Cureus.

[9]  H. Qiu,et al.  Insights of heat shock protein 22 in the cardiac protection against ischemic oxidative stress , 2020, Redox biology.

[10]  W. Boelens Structural aspects of the human small heat shock proteins related to their functional activities , 2020, Cell Stress and Chaperones.

[11]  Ke Peng,et al.  Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling , 2020, Oxidative medicine and cellular longevity.

[12]  M. Yohda,et al.  Functional and structural characterization of HspB1/Hsp27 from Chinese hamster ovary cells , 2019, FEBS open bio.

[13]  Jian-xi Wang,et al.  Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration , 2019, Cell Death & Disease.

[14]  Dean P. Jones,et al.  Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice , 2019, Redox biology.

[15]  H. Watkins,et al.  HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C , 2019, Science Advances.

[16]  Huali Zhang,et al.  N-acetylcysteine alleviates H2O2-induced damage via regulating the redox status of intracellular antioxidants in H9c2 cells , 2018, International journal of molecular medicine.

[17]  J. Zou,et al.  Heat‐shock protein B1 upholds the cytoplasm reduced state to inhibit activation of the Hippo pathway in H9c2 cells , 2018, Journal of cellular physiology.

[18]  A. Bax,et al.  Local unfolding of the HSP27 monomer regulates chaperone activity , 2018, Nature Communications.

[19]  G. Aldini,et al.  N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why , 2018, Free radical research.

[20]  A. Witkowska,et al.  Endogenous non-enzymatic antioxidants in the human body. , 2018, Advances in medical sciences.

[21]  A. Arrigo Mammalian HspB1 (Hsp27) is a molecular sensor linked to the physiology and environment of the cell , 2017, Cell Stress and Chaperones.

[22]  K. Davies,et al.  The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome , 2016, Free radical biology & medicine.

[23]  Chi-Tan Hu,et al.  Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2 , 2016, Oncotarget.

[24]  P. Celi,et al.  Oxidant/Antioxidant Balance in Animal Nutrition and Health: The Role of Protein Oxidation , 2015, Front. Vet. Sci..

[25]  T. Horino,et al.  Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury , 2015, PloS one.

[26]  M. Katsogiannou,et al.  Heat shock protein 27 phosphorylation state is associated with cancer progression , 2014, Front. Genet..

[27]  P. Semenyuk,et al.  Effect of disulfide crosslinking on thermal transitions and chaperone-like activity of human small heat shock protein HspB1 , 2014, Cell Stress and Chaperones.

[28]  D. Gelain,et al.  The oxidation of HSP70 is associated with functional impairment and lack of stimulatory capacity , 2014, Cell Stress and Chaperones.

[29]  K. Mearow,et al.  Cell Stress Promotes the Association of Phosphorylated HspB1 with F-Actin , 2013, PloS one.

[30]  A. Arrigo Human small heat shock proteins: Protein interactomes of homo‐ and hetero‐oligomeric complexes: An update , 2013, FEBS letters.

[31]  Masayuki Yamamoto,et al.  The absence of macrophage Nrf2 promotes early atherogenesis. , 2013, Cardiovascular research.

[32]  V. Adam,et al.  Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients. , 2012, Oncology letters.

[33]  N. Gusev,et al.  Heterooligomeric complexes of human small heat shock proteins , 2012, Cell Stress and Chaperones.

[34]  Yuzhen Shi,et al.  MicroRNA expression profiling during upland cotton gland forming age by microarray and quantitative reverse-transcription polymerase chain reaction (qRT- PCR) , 2011 .

[35]  R. Nagaraj,et al.  The role of the cysteine residue in the chaperone and anti‐apoptotic functions of human Hsp27 , 2010, Journal of cellular biochemistry.

[36]  J. S. Janicki,et al.  Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes , 2009, PloS one.

[37]  U. Moens,et al.  Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology , 2009, Cellular and Molecular Life Sciences.

[38]  P. Graceffa,et al.  Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone Function* , 2009, The Journal of Biological Chemistry.

[39]  Guo-xian Ding,et al.  Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation. , 2007, Chinese medical journal.

[40]  D. Bers,et al.  Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection. , 2007, Journal of molecular and cellular cardiology.

[41]  Y. Tao,et al.  Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis. , 2007, Biochemical and biophysical research communications.

[42]  S. Chaufour,et al.  Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels. , 2005, Antioxidants & redox signaling.

[43]  C. Diaz-latoud,et al.  Substitution of the unique cysteine residue of murine Hsp25 interferes with the protective activity of this stress protein through inhibition of dimer formation. , 2005, Antioxidants & redox signaling.

[44]  T. Veenstra,et al.  Identification of oxidized mitochondrial proteins in alcohol‐exposed human hepatoma cells and mouse liver , 2004, Proteomics.

[45]  Kenneth S. Kosik,et al.  Binding of Tau to Heat Shock Protein 27 Leads to Decreased Concentration of Hyperphosphorylated Tau and Enhanced Cell Survival* , 2004, Journal of Biological Chemistry.

[46]  P. Boekstegers,et al.  Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model. , 2004, Cardiovascular research.

[47]  K. Itoh,et al.  Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression* , 2003, Journal of Biological Chemistry.

[48]  N. Gusev,et al.  Structure and Properties of Small Heat Shock Proteins (sHsp) and Their Interaction with Cytoskeleton Proteins , 2002, Biochemistry (Moscow).

[49]  Guido Kroemer,et al.  Hsp27 negatively regulates cell death by interacting with cytochrome c , 2000, Nature Cell Biology.

[50]  A. Guimond,et al.  HSP27 Multimerization Mediated by Phosphorylation-sensitive Intermolecular Interactions at the Amino Terminus* , 1999, The Journal of Biological Chemistry.

[51]  M. Gaestel,et al.  The effect of the intersubunit disulfide bond on the structural and functional properties of the small heat shock protein Hsp25. , 1998, International journal of biological macromolecules.

[52]  R. Klemenz,et al.  Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart. , 1997, Circulation.

[53]  K. Kato,et al.  Dissociation as a result of phosphorylation of an aggregated form of the small stress protein, hsp27. , 1994, The Journal of biological chemistry.

[54]  C. Anderson,et al.  Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. , 1992, The Journal of biological chemistry.

[55]  A. Arrigo Analysis of HspB1 (Hsp27) Oligomerization and Phosphorylation Patterns and Its Interaction with Specific Client Polypeptides. , 2018, Methods in molecular biology.

[56]  A. Ibrahim,et al.  Acute myocardial infarction. , 2014, Critical care clinics.

[57]  Z. Motovska,et al.  Oxidative stress: Predictive marker for coronary artery disease. , 2013, Experimental and clinical cardiology.

[58]  P. Vallés,et al.  The Nrf2–Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO) , 2010, Cell Stress and Chaperones.

[59]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.