Association Between Apolipoprotein E e4 and Sleep-Disordered Breathing in Adults

SLEEP-DISORDERED BREATHING (SDB) is prevalent but largely undiagnosed in adults. Persons with SDB are at increased risk for hypertension and have increased cardiovascular disease (CVD) morbidity and mortality. Characteristics of SDB, including changes in sleep architecture and electroencephalogram (EEG) slowing, are also present in persons with Alzheimer disease (AD). Apolipoprotein E (ApoE), a protein involved in lipid metabolism, has 3 major allelic variants: e2, e3, and e4. While a protective effect for AD may be conferred by the ApoE e2 allele, risks for CVD and AD are increased by the ApoE e4 allele. In this study, we assessed the contribution of ApoE genetic variation to SDB, sleep architecture, and other sleep parameters.

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