Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography

[1]  Axel Montagne,et al.  Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease , 2017, Nature Reviews Neuroscience.

[2]  R. Ritch,et al.  STRUCTURAL AND FUNCTIONAL ASSESSMENT OF GLAUCOMATOUS PATIENTS WITH HIGH AND LOW-TENSION OPTIC DISC HEMORRHAGES: A COMPARATIVE STUDY , 2016 .

[3]  W. Brown,et al.  Review: Cerebral microvascular pathology in ageing and neurodegeneration , 2011, Neuropathology and applied neurobiology.

[4]  Ruikang K. Wang,et al.  Cerebral capillary velocimetry based on temporal OCT speckle contrast. , 2016, Biomedical optics express.

[5]  Philippe Pouliot,et al.  Effects of anesthesia on the cerebral capillary blood flow in young and old mice , 2015, Photonics West - Biomedical Optics.

[6]  Anna Devor,et al.  Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation , 2016, Front. Comput. Neurosci..

[7]  M. Feldman,et al.  Aging in the rat medial nucleus of the trapezoid body. III. Alterations in capillaries , 1985, Neurobiology of Aging.

[8]  T. Mori,et al.  Advance of age decreases the minimum alveolar concentrations of isoflurane and sevoflurane for maintaining bispectral index below 50. , 2009, British journal of anaesthesia.

[9]  R. Vos,et al.  Are Alzheimer’s disease, hypertension, and cerebrocapillary damage related?☆ , 2000, Neurobiology of Aging.

[10]  Egill Rostrup,et al.  Cerebral Blood Flow Response to Functional Activation , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  J. Krejza,et al.  Transcranial color Doppler sonography of basal cerebral arteries in 182 healthy subjects: age and sex variability and normal reference values for blood flow parameters. , 1999, AJR. American journal of roentgenology.

[12]  Cynthia A. Reinhart-King,et al.  Age-related vascular stiffening: causes and consequences , 2015, Front. Genet..

[13]  L. Vidal,et al.  Stereological changes in the capillary network of the aging dorsal lateral geniculate nucleus. , 2003, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[14]  M. Marion,et al.  Morphometric Analysis of Arteriolar Tortuosity in Human Cerebral White Matter of Preterm, Young, and Aged Subjects , 2007, Journal of neuropathology and experimental neurology.

[15]  M. A. Bell,et al.  Morphometric comparison of hippocampal microvasculature in ageing and demented people: Diameters and densities , 1981, Acta Neuropathologica.

[16]  David A. Boas,et al.  Quantitative cerebral blood flow with Optical Coherence Tomography , 2010, Optics express.

[17]  Ruikang K. Wang,et al.  Three dimensional optical angiography. , 2007, Optics express.

[18]  P. R. Hof,et al.  Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders , 1994, Acta Neuropathologica.

[19]  Kim Mouridsen,et al.  Capillary Dysfunction: Its Detection and Causative Role in Dementias and Stroke , 2015, Current Neurology and Neuroscience Reports.

[20]  D. Mann,et al.  Quantitative changes in cerebral cortical microvasculature in ageing and dementia , 1986, Neurobiology of Aging.

[21]  Arthur F. Kramer,et al.  Resting hippocampal blood flow, spatial memory and aging , 2010, Brain Research.

[22]  M. Goligorsky,et al.  Microvascular rarefaction , 2010, Organogenesis.

[23]  A. Hofman,et al.  Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study , 1997, The Lancet.

[24]  J. Hinds,et al.  Capillaries in aging rat olfactory bulb: A quantitative light and electron microscopic analysis , 1982, Neurobiology of Aging.

[25]  Ruikang K. Wang,et al.  Multimodal optical imaging can reveal changes in microcirculation and tissue oxygenation during skin wound healing , 2014, Lasers in surgery and medicine.

[26]  Christakis Constantinides,et al.  Effects of isoflurane anesthesia on the cardiovascular function of the C57BL/6 mouse. , 2011, ILAR journal.

[27]  G. Hutchins,et al.  Tortuosity as an index of the age and diameter increase of coronary collateral vessels in patients after acute myocardial infarction. , 1978, The American journal of cardiology.

[28]  G. Cold,et al.  Effects of dose‐dependent levels of isoflurane on cerebral blood flow in healthy subjects studied using positron emission tomography , 2006, Acta anaesthesiologica Scandinavica.

[29]  Junyang Jung,et al.  Age-related changes in pial arterial structure and blood flow in mice , 2016, Neurobiology of Aging.

[30]  M. Breteler.  Vascular Involvement in Cognitive Decline and Dementia: Epidemiologic Evidence from the Rotterdam Study and the Rotterdam Scan Study , 2000, Annals of the New York Academy of Sciences.

[31]  O. Yildiz.  Vascular Smooth Muscle and Endothelial Functions in Aging , 2007, Annals of the New York Academy of Sciences.

[32]  V. Challa,et al.  Cerebrovascular Pathology in Alzheimer's Disease and Leukoaraiosis , 2000, Annals of the New York Academy of Sciences.

[33]  H. Reinhold,et al.  A QUANTITATIVE STUDY OF AGE‐RELATED CHANGES IN THE VASCULAR ARCHITECTURE OF THE RAT CEREBRAL CORTEX , 1981, Neuropathology and applied neurobiology.

[34]  M. Chakravarty,et al.  Brain Energy Metabolism and Blood Flow Differences in Healthy Aging , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  A. Dorrance,et al.  Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles. , 2016, American journal of physiology. Heart and circulatory physiology.

[36]  D. Sane,et al.  Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. , 2002, Cardiovascular research.

[37]  Cha-Min Tang,et al.  Coherence-gated Doppler: a fiber sensor for precise localization of blood flow , 2013, Biomedical optics express.

[38]  Ruikang K. Wang,et al.  Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry , 2018, Scientific Reports.

[39]  Stephen R. Aylward,et al.  The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography , 2010, Neurobiology of Aging.

[40]  M. A. Bell,et al.  Does tortuosity in cerebral arterioles impair down-autoregulation in hypertensives and elderly normotensives? A hypothesis and computer model. , 1991, Clinical neurosurgery.

[41]  Tianxiang Chen,et al.  Age-related Impairment of Vascular Structure and Functions , 2017, Aging and disease.

[42]  B. Weber,et al.  Topology and hemodynamics of the cortical cerebrovascular system , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[43]  P. Hutchins,et al.  Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. , 1997, Endocrinology.

[44]  Thomas L. Smith,et al.  Effects of anesthetics on systemic hemodynamics in mice. , 2004, American journal of physiology. Heart and circulatory physiology.

[45]  Nick Efford,et al.  Digital Image Processing: A Practical Introduction Using Java , 2000 .

[46]  Ruikang K. Wang,et al.  Application of Thinned-Skull Cranial Window to Mouse Cerebral Blood Flow Imaging Using Optical Microangiography , 2014, PloS one.

[47]  Ruikang K. Wang,et al.  Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography , 2011, Biomedical optics express.

[48]  David Kleinfeld,et al.  Penetrating arterioles are a bottleneck in the perfusion of neocortex , 2007, Proceedings of the National Academy of Sciences.

[49]  Michèle Desjardins,et al.  Aging-related differences in cerebral capillary blood flow in anesthetized rats , 2014, Neurobiology of Aging.

[50]  Carmen A. Puliafito,et al.  Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography , 2016, Investigative ophthalmology & visual science.

[51]  Michael Hermes,et al.  Resting cerebral blood flow, attention, and aging , 2009, Brain Research.

[52]  Moody Dm,et al.  Does tortuosity in cerebral arterioles impair down-autoregulation in hypertensives and elderly normotensives? A hypothesis and computer model. , 1991 .

[53]  W. Denk,et al.  Deep tissue two-photon microscopy , 2005, Nature Methods.

[54]  Leif Østergaard,et al.  The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[55]  N C Andreasen,et al.  Age-related changes in regional cerebral blood flow among young to mid-life adults. , 1999, Neuroreport.

[56]  M. A. Bell,et al.  Microvascular Density of the Human Paraventricular Nucleus Decreases with Aging but Not Hypertension , 1993, Experimental Neurology.

[57]  L. Vutskits,et al.  Lasting impact of general anaesthesia on the brain: mechanisms and relevance , 2016, Nature Reviews Neuroscience.

[58]  C. Knox,et al.  Brain aging in normotensive and hypertensive strains of rats , 2004, Acta Neuropathologica.

[59]  Arne Møller,et al.  The capillary dysfunction hypothesis of Alzheimer's disease , 2013, Neurobiology of Aging.

[60]  Ş. Demirkaya,et al.  Normal blood flow velocities of basal cerebral arteries decrease with advancing age: a transcranial Doppler sonography study. , 2008, The Tohoku journal of experimental medicine.

[61]  David H. Salat,et al.  Age-associated reductions in cerebral blood flow are independent from regional atrophy , 2011, NeuroImage.

[62]  R. Weller,et al.  Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer’s disease Pro-CAA position statement , 2004, Neurobiology of Aging.

[63]  S M Blinkov,et al.  Rarefication of the arterioles and capillary network in the brain of rats with different forms of hypertension. , 1985, Microvascular research.

[64]  F. Amenta,et al.  Age-related changes in brain microanatomy: Sensitivity to treatment with the dihydropyridine calcium channel blocker darodipine (PY 108-068) , 1995, Brain Research Bulletin.

[65]  M. Burnett,et al.  Aging Causes Collateral Rarefaction and Increased Severity of Ischemic Injury in Multiple Tissues , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[66]  K. Bättig,et al.  Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network , 1990, Neurobiology of Aging.

[67]  Dixon M. Moody,et al.  Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well , 2007, Journal of the Neurological Sciences.

[68]  Chen Xin,et al.  Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography , 2016, Journal of biomedical optics.

[69]  Hai-Chao Han.  Twisted Blood Vessels: Symptoms, Etiology and Biomechanical Mechanisms , 2012, Journal of Vascular Research.

[70]  Ruikang K. Wang,et al.  Wide velocity range Doppler optical microangiography using optimized step-scanning protocol with phase variance mask , 2013, Journal of biomedical optics.

[71]  A. Fleisher,et al.  Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation , 2009, Human brain mapping.

[72]  Ruikang K. Wang,et al.  Vasodynamics of pial and penetrating arterioles in relation to arteriolo-arteriolar anastomosis after focal stroke , 2015, Neurophotonics.

[73]  Ruikang K. Wang,et al.  Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo. , 2009, Optics express.

[74]  K. Jellinger,et al.  The overlap between vascular disease and Alzheimer’s disease - lessons from pathology , 2014, BMC Medicine.

[75]  E. Burns,et al.  Changes with age in cerebral capillary morphology , 1981, Neurobiology of Aging.

[76]  Ruikang K. Wang,et al.  Optical coherence tomography angiography-based capillary velocimetry , 2017, Journal of biomedical optics.

[77]  V. Fischer,et al.  Altered angioarchitecture in selected areas of brains with Alzheimer's disease , 2004, Acta Neuropathologica.

[78]  J. C. Torre,et al.  Critical threshold cerebral hypoperfusion causes Alzheimer’s disease? , 1999, Acta Neuropathologica.

[79]  S. Bennett,et al.  Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats☆ , 1999, Neurobiology of Aging.

[80]  H. Goldman,et al.  Age-related changes in regional cerebral blood flow and behavior in Sprague-Dawley rats , 1988, Neurobiology of Aging.

[81]  Hirofumi Tanaka,et al.  Age-associated elongation of the ascending aorta in adults. , 2008, JACC. Cardiovascular imaging.

[82]  P. Luiten,et al.  Cerebral microvascular pathology in aging and Alzheimer's disease , 2001, Progress in Neurobiology.

[83]  M. A. Bell,et al.  Arteriolar Tortuosity of the White Matter in Aging and Hypertension. A Microradiographic Study , 1994, Journal of neuropathology and experimental neurology.