Microglial self-defence mediated through GLT-1 and glutathione

[1]  J. Kong,et al.  Oxidative stress in neurodegenerative diseases , 2012, Neural regeneration research.

[2]  E. Hansson,et al.  Microglial GLT‐1 is upregulated in response to herpes simplex virus infection to provide an antiviral defence via glutathione , 2007, Glia.

[3]  M. Persson.  Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions , 2007 .

[4]  E. Hansson,et al.  Corticosterone inhibits expression of the microglial glutamate transporter GLT-1 in vitro , 2006, Neuroscience.

[5]  G. Gras,et al.  The glutamate‐glutamine cycle as an inducible, protective face of macrophage activation , 2006, Journal of leukocyte biology.

[6]  G. Gras,et al.  Glutamate metabolism in HIV-infected macrophages: implications for the CNS. , 2006, American journal of physiology. Cell physiology.

[7]  E. Hansson,et al.  Microglial glutamate uptake is coupled to glutathione synthesis and glutamate release , 2006, The European journal of neuroscience.

[8]  G. Gras,et al.  Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production. , 2006, Virology.

[9]  D. Pow,et al.  Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1 , 2006, Neurochemistry International.

[10]  G. Raivich.  Like cops on the beat: the active role of resting microglia , 2005, Trends in Neurosciences.

[11]  C. Behl,et al.  Differential Promotion of Glutamate Transporter Expression and Function by Glucocorticoids in Astrocytes from Various Brain Regions* , 2005, Journal of Biological Chemistry.

[12]  D. Knipe,et al.  Herpes simplex virus and toll-like receptors. , 2005, Viral immunology.

[13]  Rajagopal N. Aravalli,et al.  Cutting Edge: TLR2-Mediated Proinflammatory Cytokine and Chemokine Production by Microglial Cells in Response to Herpes Simplex Virus1 , 2005, The Journal of Immunology.

[14]  V. Hukkanen,et al.  Immune Response to Herpes Simplex Virus and ?134.5 Deleted HSV Vectors , 2005 .

[15]  E. Hansson,et al.  Lipopolysaccharide increases microglial GLT‐1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF‐α , 2005, Glia.

[16]  L. Minghetti.  Role of inflammation in neurodegenerative diseases , 2005, Current opinion in neurology.

[17]  M. Nilsson,et al.  Astrocyte activation and reactive gliosis , 2005, Glia.

[18]  K. Nakano,et al.  HSV trafficking and development of gene therapy vectors with applications in the nervous system , 2005, Gene Therapy.

[19]  K. Pfeffer,et al.  The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games , 2005, Immunology.

[20]  H. Kettenmann,et al.  Physiology of microglial cells , 2005, Brain Research Reviews.

[21]  M. Schwartz,et al.  Protective autoimmunity: interferon‐γ enables microglia to remove glutamate without evoking inflammatory mediators , 2005, Journal of neurochemistry.

[22]  W. Colledge.  Faculty Opinions recommendation of Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. , 2005 .

[23]  P. Fisher,et al.  β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression , 2005, Nature.

[24]  E. Hansson,et al.  On the potential role of glutamate transport in mental fatigue , 2004, Journal of Neuroinflammation.

[25]  D. Dormont,et al.  Expression of Excitatory Amino Acid Transporter‐1 (EAAT‐1) in Brain Macrophages and Microglia of Patients with Prion Diseases , 2004, Journal of neuropathology and experimental neurology.

[26]  K. Schlett,et al.  Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation , 2004, Journal of Biological Chemistry.

[27]  K. Tyler.  Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's. , 2004, Herpes : the journal of the IHMF.

[28]  O. Hurtado,et al.  In Vitro Ischemic Tolerance Involves Upregulation of Glutamate Transport Partly Mediated by the TACE/ADAM17-Tumor Necrosis Factor-α Pathway , 2004, The Journal of Neuroscience.

[29]  D. Kimberlin.  Neonatal Herpes Simplex Infection , 2004, Clinical Microbiology Reviews.

[30]  S. Baruchel,et al.  Functional Expression of the Multidrug Resistance Protein 1 in Microglia , 2003, Journal of Pharmacology and Experimental Therapeutics.

[31]  R. Hohlfeld,et al.  Molecular pathogenesis of neuroinflammation , 2003, Journal of neurology, neurosurgery, and psychiatry.

[32]  M. Schwartz,et al.  Protective autoimmunity against the enemy within: fighting glutamate toxicity , 2003, Trends in Neurosciences.

[33]  S. Brooke,et al.  Effects of glucocorticoids in the gp120-induced inhibition of glutamate uptake in hippocampal cultures , 2003, Brain Research.

[34]  D. Dormont,et al.  Expression of Excitatory Amino Acid Transporter‐1 in Brain Macrophages and Microglia of HIV‐Infected Patients. A Neuroprotective Role for Activated Microglia? , 2003, Journal of neuropathology and experimental neurology.

[35]  J. Hirrlinger,et al.  Glutathione Pathways in the Brain , 2003, Biological chemistry.

[36]  M. Cheeran,et al.  Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis. , 2002, The Journal of infectious diseases.

[37]  J. Hallenbeck.  The many faces of tumor necrosis factor in stroke , 2002, Nature Medicine.

[38]  R. O'Shea.  Roles and regulation of glutamate transporters in the central nervous system , 2002, Clinical and experimental pharmacology & physiology.

[39]  D. Dormont,et al.  Expression of excitatory amino acid transporter‐2 (EAAT‐2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251‐infected macaques , 2002, Neuropathology and applied neurobiology.

[40]  J. Herman,et al.  Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampus , 2002, Brain Research.

[41]  E. Melamed,et al.  Antioxidant Therapy in Acute Central Nervous System Injury: Current State , 2002, Pharmacological Reviews.

[42]  N. Ballatori,et al.  Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2. , 2002, Biochimica et biophysica acta.

[43]  D. Dormont,et al.  Role of glutamate transporters in the regulation of glutathione levels in human macrophages. , 2001, American journal of physiology. Cell physiology.

[44]  F. Piehl,et al.  Neuroinflammation in the rat – CNS cells and their role in the regulation of immune reactions , 2001, Immunological reviews.

[45]  F. Aloisi.  Immune function of microglia , 2001, Glia.

[46]  P. Eriksson,et al.  Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes. , 2001, American journal of physiology. Cell physiology.

[47]  E. Benveniste,et al.  Immune function of astrocytes , 2001, Glia.

[48]  N. Matsuki,et al.  Transient upregulation of the glial glutamate transporter GLAST in response to fibroblast growth factor, insulin-like growth factor and epidermal growth factor in cultured astrocytes. , 2001, Journal of cell science.

[49]  N. Danbolt.  Glutamate uptake , 2001, Progress in Neurobiology.

[50]  I. Bechmann,et al.  Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat , 2001, Glia.

[51]  S. Kohsaka,et al.  Ability of rat microglia to uptake extracellular glutamate , 2001, Neuroscience Letters.

[52]  E. Schmutzhard.  Viral infections of the CNS with special emphasis on herpes simplex infections , 2001, Journal of Neurology.

[53]  S. Liao,et al.  Differential effects of cytokines and redox potential on glutamate uptake in rat cortical glial cultures , 2001, Neuroscience Letters.

[54]  A. Goryachev,et al.  Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response , 2001, Journal of Virology.

[55]  R. Dringen,et al.  Metabolism and functions of glutathione in brain , 2000, Progress in Neurobiology.

[56]  J. Hirrlinger,et al.  Microglial Cells in Culture Express a Prominent Glutathione System for the Defense against Reactive Oxygen Species , 2000, Developmental Neuroscience.

[57]  Jon Sinclair,et al.  Astroglia and glutamate in physiology and pathology: aspects on glutamate transport, glutamate-induced cell swelling and gap-junction communication , 2000, Neurochemistry International.

[58]  H. Abe,et al.  Protective effect of microglial conditioning medium on neuronal damage induced by glutamate , 2000, Neuroscience Letters.

[59]  A. Unterberg,et al.  Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-α in relation to brain edema and contusion following controlled cortical impact injury in rats , 2000, Neuroscience Letters.

[60]  Y. Nakamura,et al.  [Regulating factors for microglial activation]. , 2000, Seikagaku. The Journal of Japanese Biochemical Society.

[61]  D. Dormont,et al.  Na+-Dependent High-Affinity Glutamate Transport in Macrophages1 , 2000, The Journal of Immunology.

[62]  M. Figiel,et al.  Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a Neuron-Derived Peptide Regulating Glial Glutamate Transport and Metabolism , 2000, The Journal of Neuroscience.

[63]  S. Kohsaka,et al.  Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy. , 2000, Brain research. Molecular brain research.

[64]  M. Tymianski,et al.  Molecular mechanisms of calcium-dependent excitotoxicity , 2000, Journal of Molecular Medicine.

[65]  J. Hirrlinger,et al.  Purification of Glutathione Reductase from Bovine Brain, Generation of an Antiserum, and Immunocytochemical Localization of the Enzyme in Neural Cells , 1999, Journal of neurochemistry.

[66]  S. Rogers,et al.  Inflammatory Cytokines IL-1α, IL-1β, IL-6, and TNF-α Impart Neuroprotection to an Excitotoxin Through Distinct Pathways , 1999, The Journal of Immunology.

[67]  Leif Hertz,et al.  Astrocytes: Glutamate producers for neurons , 1999, Journal of neuroscience research.

[68]  G. Keilhoff,et al.  Glutathione levels in primary glial cultures: Monochlorobimane provides evidence of cell type‐specific distribution , 1999, Glia.

[69]  J. Fawcett,et al.  The glial scar and central nervous system repair , 1999, Brain Research Bulletin.

[70]  J. Hallenbeck,et al.  Dual role of tumor necrosis factor alpha in brain injury. , 1999, Cytokine & growth factor reviews.

[71]  H. Nakanishi,et al.  Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide , 1999, Neuroscience.

[72]  W. Streit,et al.  Reactive microgliosis , 1999, Progress in Neurobiology.

[73]  T. Ishii,et al.  Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins* , 1999, The Journal of Biological Chemistry.

[74]  A. Palamara,et al.  Increased replication of Sendai virus in morphine-treated epithelial cells: evidence for the involvement of the intracellular levels of glutathione. , 1999, International journal of immunopharmacology.

[75]  R. Evers,et al.  Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. , 1999, The Biochemical journal.

[76]  H. Noack,et al.  Enhanced cellular glutathione peroxidase immunoreactivity in activated astrocytes and in microglia during excitotoxin induced neurodegeneration , 1998, Glia.

[77]  D. Watanabe,et al.  Glutamate receptors: brain function and signal transduction 1 Published on the World Wide Web on 21 October 1997. 1 , 1998, Brain Research Reviews.

[78]  J. Rothstein,et al.  Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons. , 1998, Molecular pharmacology.

[79]  A. Schousboe,et al.  Cellular Distribution and Kinetic Properties of High-Affinity Glutamate Transporters , 1998, Brain Research Bulletin.

[80]  R. Albin.  The Molecular and Genetic Basis of Neurological Disease , 1997 .

[81]  F. Homa,et al.  Capsid assembly and DNA packaging in herpes simplex virus , 1997, Reviews in medical virology.

[82]  H. Nawashiro,et al.  TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice , 1997 .

[83]  M. Kavanaugh,et al.  Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[84]  T. Ohtsuki,et al.  Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats , 1997, Brain Research.

[85]  H. Nawashiro,et al.  Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in Mice , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[86]  A. Palamara,et al.  Loss of GSH, Oxidative Stress, and Decrease of Intracellular pH as Sequential Steps in Viral Infection* , 1997, The Journal of Biological Chemistry.

[87]  R. Rosenberg.  The Molecular and Genetic Basis of Neurological Disease , 1997 .

[88]  A. Palamara,et al.  Cocaine increases Sendai virus replication in cultured epithelial cells: critical role of the intracellular redox status. , 1996, Biochemical and biophysical research communications.

[89]  A. Palamara,et al.  Glutathione inhibits HIV replication by acting at late stages of the virus life cycle. , 1996, AIDS research and human retroviruses.

[90]  Masahiko Watanabe,et al.  EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. , 1996, Neuroreport.

[91]  G. Kreutzberg.  Microglia: a sensor for pathological events in the CNS , 1996, Trends in Neurosciences.

[92]  P. Gebicke-haerter,et al.  Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases. , 1996, Neurochemistry international.

[93]  J. Rothstein,et al.  Tumor Necrosis Factor (cid:97) Inhibits Glutamate Uptake by Primary Human Astrocytes FOR PATHOGENESIS OF HIV-1 , 2022 .

[94]  G. Riedel.  Function of metabotropic glutamate receptors in learning and memory. , 1996, Trends in neurosciences.

[95]  S. Bannai,et al.  Glutathione Efflux from Cultured Astrocytes , 1996, Journal of neurochemistry.

[96]  A. Volterra,et al.  Peroxynitrite Inhibits Glutamate Transporter Subtypes (*) , 1996, The Journal of Biological Chemistry.

[97]  D. Keppler,et al.  ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. , 1996, The Biochemical journal.

[98]  K. Barron.  The microglial cell. A historical review , 1995, Journal of the Neurological Sciences.

[99]  M. Kavanaugh,et al.  An excitatory amino-acid transporter with properties of a ligand-gated chloride channel , 1995, Nature.

[100]  A. Palamara,et al.  Evidence for antiviral activity of glutathione: in vitro inhibition of herpes simplex virus type 1 replication. , 1995, Antiviral research.

[101]  R. Swanson,et al.  Journal of Cerebral Blood Flow and Metabolism Acidosis Causes Failure of Astrocyte Glutamate Uptake during Hypoxia , 2022 .

[102]  T. Marunouchi,et al.  Expression of glutamate transporters in cultured glial cells , 1995, Neuroscience Letters.

[103]  G. Kreutzberg,et al.  Microglia: Intrinsic immuneffector cell of the brain , 1995, Brain Research Reviews.

[104]  M. Kuhar,et al.  Nitric oxide inhibits 3H‐glutamate transport in synaptosomes , 1994, Synapse.

[105]  A. Volterra,et al.  Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[106]  R. Swanson.  Astrocyte glutamate uptake during chemical hypoxia in vitro , 1992, Neuroscience Letters.

[107]  M. Hediger,et al.  Primary structure and functional characterization of a high-affinity glutamate transporter , 1992, Nature.

[108]  E. Seeberg,et al.  Cloning and expression of a rat brain L-glutamate transporter , 1992, Nature.

[109]  A. Palamara,et al.  Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus. , 1992, Biochemical and biophysical research communications.

[110]  T. Storck,et al.  Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[111]  P. Rosenberg,et al.  Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[112]  R. Sapolsky,et al.  Glucocorticoids Inhibit Glucose Transport and Glutamate Uptake in Hippocampal Astrocytes: Implications for Glucocorticoid Neurotoxicity , 1991, Journal of neurochemistry.

[113]  G. Kaplan,et al.  Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes , 1991, The Journal of experimental medicine.

[114]  I. Silver,et al.  Metabolism and role of glutamate in mammalian brain , 1990, Progress in Neurobiology.

[115]  V. Perry,et al.  Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain , 1990, Neuroscience.

[116]  S. Bannai,et al.  Uptake of Glutamate and Cystine in C‐6 Glioma Cells and in Cultured Astrocytes , 1990, Journal of neurochemistry.

[117]  T. Murphy,et al.  Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[118]  T. Murphy,et al.  Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress , 1989, Neuron.

[119]  S. Bannai.  Exchange of cystine and glutamate across plasma membrane of human fibroblasts. , 1986, The Journal of biological chemistry.

[120]  H. Benveniste,et al.  Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis , 1984, Journal of neurochemistry.

[121]  R. Reichman.  Herpes simplex virus infections , 1984, European Journal of Clinical Microbiology.

[122]  F. Fonnum.  Glutamate: A Neurotransmitter in Mammalian Brain , 1984, Journal of neurochemistry.

[123]  B Chance,et al.  Hydroperoxide metabolism in mammalian organs. , 1979, Physiological reviews.

[124]  A. Meister,et al.  Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. , 1975, The Journal of biological chemistry.

[125]  J. Olney.  Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate , 1969, Science.

[126]  G. Gras,et al.  EAAT expression by macrophages and microglia: still more questions than answers , 2011, Amino Acids.

[127]  Hideyo Sato,et al.  The oxidative stress-inducible cystine/glutamate antiporter, system xc−: cystine supplier and beyond , 2011, Amino Acids.

[128]  L. Had‐Aissouni.  Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance , 2011, Amino Acids.

[129]  P. Maher,et al.  Regulation of xCT expression and system $$ x_{\text{c}}^{ - } $$ function in neuronal cells , 2011, Amino Acids.

[130]  E. Hansson,et al.  Astrocyte–endothelial interactions at the blood–brain barrier , 2006, Nature Reviews Neuroscience.

[131]  V. Hukkanen,et al.  Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors. , 2005, Current gene therapy.

[132]  P. Dodd.  Excited to death: different ways to lose your neurones , 2004, Biogerontology.

[133]  R. Hohlfeld,et al.  Molecular pathogenesis of neuroinflammation , 2003 .

[134]  M. Kúdelová,et al.  Early shutoff of host protein synthesis in cells infected with herpes simplex viruses. , 2001, Acta virologica.

[135]  M. Cheeran,et al.  Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus. , 2001, Journal of neurovirology.

[136]  A. Brawanski,et al.  S-100B Protein Serum Levels After Controlled Cortical Impact Injury in the Rat , 2000, Acta Neurochirurgica.

[137]  S. Rogers,et al.  Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. , 1999, Journal of immunology.

[138]  Louis Sokoloff,et al.  Circulation and Energy Metabolism of the Brain , 1999 .

[139]  A. Schousboe,et al.  Glutamate transport and metabolism in astrocytes. , 1997, Glia.

[140]  H. Nawashiro,et al.  TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice. , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[141]  H. Hartung,et al.  Molecular mechanisms of microglial activation. , 1996, Advances in neuroimmunology.

[142]  B. Sköldenberg.  Herpes simplex encephalitis. , 1991, Scandinavian journal of infectious diseases. Supplementum.

[143]  P. Molinoff,et al.  Basic Neurochemistry: Molecular, Cellular and Medical Aspects , 1989 .

[144]  A. Schousboe.  Transport and metabolism of glutamate and GABA in neurons are glial cells. , 1981, International review of neurobiology.

[145]  Arne Schousboe,et al.  Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells , 1981 .