Microkeratome-Assisted Superficial Anterior Lamellar Keratoplasty for Anterior Stromal Corneal Opacities After Penetrating Keratoplasty

Purpose: To describe the surgical technique and report the outcomes of patients treated with microkeratome-assisted superficial anterior lamellar keratoplasty for anterior stromal corneal opacities developing after penetrating keratoplasty (PK). Methods: All patients with post-penetrating keratoplasty anterior stromal opacities treated with microkeratome-assisted superficial anterior lamellar keratoplasty between July 2005 and June 2007 were reviewed. A 130-μm superficial keratectomy was performed, followed by the placement of an appropriately sized donor graft, which was secured with overlay sutures. Refraction, corneal topography, and uncorrected and best-corrected visual acuities (UCVA, BCVA, respectively) were noted at each examination. Results: Nine eyes of 8 consecutive patients were identified. Causes of anterior stromal opacities included dystrophy recurrence (n = 3), post–photorefractive keratectomy haze (n = 2), and scarring after stromal melt (n = 4). BCVA improved in all 9 eyes at final follow-up, and 7 of 9 eyes achieved ≥20/40 within the first month. Average follow-up period was 28 ± 3.9 months. Refractive astigmatism also improved by an average of 0.7 diopters. Conclusions: Superficial anterior lamellar keratoplasty is a viable and effective alternative to repeat PK in treating anterior stromal scars. It avoids open-globe surgery and exposure to endothelial rejection associated with repeat PK, and visual rehabilitation is considerably quicker.

[1]  J. Mehta,et al.  Anterior lamellar keratoplasty over penetrating keratoplasty for optical, therapeutic, and tectonic indications: a case series. , 2009, American journal of ophthalmology.

[2]  Z. Yalniz-Akkaya,et al.  Repeat Penetrating Keratoplasty: Indications and Prognosis, 1995–2005 , 2009, European journal of ophthalmology.

[3]  C. McGhee,et al.  Rapid visual recovery after penetrating keratoplasty for keratoconus , 2008, Clinical & experimental ophthalmology.

[4]  J. Mehta,et al.  Future Directions in Lamellar Corneal Transplantation , 2007, Cornea.

[5]  R. Tandon,et al.  Automated lamellar therapeutic keratoplasty (ALTK) in the treatment of anterior to mid-stromal corneal pathologies. , 2006, Acta ophthalmologica Scandinavica.

[6]  M. Busin Microkeratome-Assisted Superficial Anterior Lamellar Keratoplasty , 2006 .

[7]  N. Sharma,et al.  Corneal lamellar flap retraction after LASIK following penetrating keratoplasty. , 2006, Cornea.

[8]  H. Al‐Mezaine,et al.  Repeat penetrating keratoplasty: indications, graft survival, and visual outcome , 2006, British Journal of Ophthalmology.

[9]  J. Qu,et al.  Automated lamellar keratoplasty for recurrent granular corneal dystrophy after phototherapeutic keratectomy. , 2005, Journal of refractive surgery.

[10]  D. Tan,et al.  Automated lamellar therapeutic keratoplasty for post-PRK corneal scarring and thinning. , 2004, American journal of ophthalmology.

[11]  E. Donnenfeld,et al.  Lamellar Keratectomy Using an Automated Microkeratome , 2004, Eye & contact lens.

[12]  R. Tandon,et al.  Laser in-situ keratomileusis after penetrating keratoplasty. , 2003, Survey of ophthalmology.

[13]  Robert W. Thompson,et al.  Long-term graft survival after penetrating keratoplasty. , 2003, Ophthalmology.

[14]  E. Cohen,et al.  Recurrence of Corneal Stromal Dystrophies After Penetrating Keratoplasty , 2003, Cornea.

[15]  J. Alió,et al.  New techniques in lamellar keratoplasty. , 2002, Current opinion in ophthalmology.

[16]  Mohammed Anwar,et al.  Big‐bubble technique to bare Descemet's membrane in anterior lamellar keratoplasty , 2002, Journal of cataract and refractive surgery.

[17]  I. Jiménez‐Alfaro,et al.  Therapeutic lamellar keratoplasty with an automated microkeratome. , 2001, Journal of cataract and refractive surgery.

[18]  M. Doğru,et al.  Refractive changes after excimer laser phototherapeutic keratectomy , 2001, Journal of cataract and refractive surgery.

[19]  N. P. Patel,et al.  Indications for and outcomes of repeat penetrating keratoplasty, 1989-1995. , 2000, Ophthalmology.

[20]  Y. Rabinowitz,et al.  Superficial lamellar keratectomy using an automated microkeratome to excise corneal scarring caused by photorefractive keratectomy. , 1999, Journal of cataract and refractive surgery.

[21]  A. Geerards,et al.  The future of lamellar keratoplasty. , 1999, Current opinion in ophthalmology.

[22]  D. Salchow,et al.  Laser in situ keratomileusis after automated lamellar keratoplasty and penetrating keratoplasty , 1997, Journal of cataract and refractive surgery.

[23]  E. Donnenfeld,et al.  Excimer laser phototherapeutic keratectomy. , 1997, Cornea.

[24]  A. Steele,et al.  Granular corneal dystrophy. Visual results and pattern of recurrence after lamellar or penetrating keratoplasty. , 1994, Ophthalmology.

[25]  T. Prager,et al.  Visual improvement as a function of time after lamellar keratoplasty for keratoconus. , 1993, American journal of ophthalmology.

[26]  E. Cohen,et al.  Indications for and outcomes of repeat penetrating keratoplasty. , 1990, American journal of ophthalmology.