Illustrated State‐of‐the‐Art Capsules of the ISTH 2020 Congress

This year's Congress of the International Society of Thrombosis and Haemostasis (ISTH) was hosted virtually from Philadelphia July 17–21, 2021. The conference, now held annually, highlighted cutting‐edge advances in basic, population and clinical sciences of relevance to the Society. Despite being held virtually, the 2021 congress was of the same scope and quality as an annual meeting held in person. An added feature of the program is that talks streamed at the designated times will then be available on‐line for asynchronous viewing. The program included 77 State of the Art (SOA) talks, thematically grouped in 28 sessions, given by internationally recognized leaders in the field. The SOA speakers were invited to prepare brief illustrated reviews of their talks that were peer reviewed and are included in this article. The topics, across the main scientific themes of the congress, include Arterial Thromboembolism, Coagulation and Natural Anticoagulants, COVID‐19 and Coagulation, Diagnostics and Omics, Fibrinogen, Fibrinolysis and Proteolysis, Hemophilia and Rare Bleeding Disorders, Hemostasis in Cancer, Inflammation and Immunity, Pediatrics, Platelet Disorders, von Willebrand Disease and Thrombotic Angiopathies, Platelets and Megakaryocytes, Vascular Biology, Venous Thromboembolism and Women's Health. These illustrated capsules highlight the major scientific advances with potential to impact clinical practice. Readers are invited to take advantage of the excellent educational resource provided by these illustrated capsules. They are also encouraged to use the image in social media to draw attention to the high quality and impact of the science presented at the congress.

[1]  C. Dubois,et al.  DNAse-dependent, NET-independent pathway of thrombus formation in vivo , 2021, Proceedings of the National Academy of Sciences.

[2]  Lara A. Kahale,et al.  American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. , 2021, Blood advances.

[3]  H. Spencer,et al.  Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor. , 2021, Blood.

[4]  P. Hogg Multiple Disulfide-Bonded States of Native Proteins: Estimate of Number Using Probabilities of Disulfide Bond Formation , 2020, Molecules.

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[9]  C. Dubois,et al.  Cancer animal models in thrombosis research. , 2020, Thrombosis research.

[10]  W. Ageno,et al.  Anticoagulant therapy for splanchnic vein thrombosis , 2020, Journal of thrombosis and haemostasis : JTH.

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[13]  J. O’Sullivan,et al.  Von Willebrand factor and cancer; metastasis and coagulopathies , 2020, Journal of thrombosis and haemostasis : JTH.

[14]  K. Downes,et al.  Strengths and limitations of high‐throughput sequencing for the diagnosis of inherited bleeding and platelet disorders , 2020, Journal of thrombosis and haemostasis : JTH.

[15]  Weikai Li,et al.  Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy. , 2020, Blood advances.

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[22]  V. Schroeder,et al.  Identification of amino acid residues that are crucial for FXIII-A intersubunit interactions and stability. , 2019, Blood.

[23]  D. Strickland,et al.  Fibrin-VLDL Receptor-Dependent Pathway Promotes Leukocyte Transmigration by Inhibiting Src Kinase Fyn and is a Target for Fibrin β15-42 Peptide , 2019, Thrombosis and Haemostasis.

[24]  W. Aird,et al.  The in vivo endothelial cell translatome is highly heterogeneous across vascular beds , 2019, Proceedings of the National Academy of Sciences.

[25]  W. Ouwehand,et al.  Curated disease‐causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH , 2019, Journal of thrombosis and haemostasis : JTH.

[26]  F. Rosendaal,et al.  Endogenous sex hormones and risk of venous thromboembolism in young women , 2019, Journal of thrombosis and haemostasis : JTH.

[27]  R. Collis,et al.  Management of postpartum haemorrhage: from research into practice, a narrative review of the literature and the Cardiff experience. , 2019, International journal of obstetric anesthesia.

[28]  V. Venkatesh,et al.  Randomized Trial of Platelet‐Transfusion Thresholds in Neonates , 2019, The New England journal of medicine.

[29]  T. Barbui,et al.  Hydroxyurea prevents arterial and late venous thrombotic recurrences in patients with myeloproliferative neoplasms but fails in the splanchnic venous district. Pooled analysis of 1500 cases , 2018, Blood Cancer Journal.

[30]  P. James,et al.  Significant gynecological bleeding in women with low von Willebrand factor levels. , 2018, Blood advances.

[31]  E. Fox,et al.  Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial. , 2018, Blood advances.

[32]  Junmei Chen,et al.  Inflammation, von Willebrand factor, and ADAMTS13. , 2018, Blood.

[33]  Troy Richardson,et al.  Increasing rate of pulmonary embolism diagnosed in hospitalized children in the United States from 2001 to 2014. , 2018, Blood advances.

[34]  N. Goldenberg,et al.  Recommendations for future research in relation to pediatric pulmonary embolism: communication from the SSC of the ISTH , 2018, Journal of thrombosis and haemostasis : JTH.

[35]  K. Hood,et al.  Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial , 2017, British journal of anaesthesia.

[36]  E. Amankwah,et al.  Pulmonary embolism and in situ pulmonary artery thrombosis in paediatrics , 2017, Thrombosis and Haemostasis.

[37]  M. Gross,et al.  Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer , 2016, Nature Structural &Molecular Biology.

[38]  J. O’Donnell,et al.  Emerging roles for hemostatic dysfunction in malaria pathogenesis. , 2016, Blood.

[39]  V. Schroeder,et al.  Factor XIII: Structure and Function , 2016, Seminars in Thrombosis & Hemostasis.

[40]  V. Schroeder,et al.  The activation peptide of coagulation factor XIII is vital for its expression and stability , 2015, Journal of thrombosis and haemostasis : JTH.

[41]  J. Eikenboom,et al.  Primary postpartum haemorrhage in women with von Willebrand disease or carriership of haemophilia despite specialised care: a retrospective survey , 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

[42]  B. Konkle,et al.  Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis , 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

[43]  A. Craig,et al.  A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. , 2014, Blood.

[44]  A. Weeks,et al.  Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. , 2014, Blood.

[45]  M. Nijziel,et al.  von Willebrand disease and aging: an evolving phenotype , 2014, Journal of thrombosis and haemostasis : JTH.

[46]  Özge Tunçalp,et al.  Global causes of maternal death: a WHO systematic analysis. , 2014, The Lancet. Global health.

[47]  S. le Cessie,et al.  Sex Difference in Risk of Second but Not of First Venous Thrombosis: Paradox Explained , 2014, Circulation.

[48]  Shannon L Meeks,et al.  Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. , 2013, Blood.

[49]  D. Cook,et al.  Heparin Thromboprophylaxis in Medical-Surgical Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Trials* , 2013, Critical care medicine.

[50]  M. Cazzola,et al.  Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study , 2013, Leukemia.

[51]  S. Assmann,et al.  The impact of platelet transfusion characteristics on posttransfusion platelet increments and clinical bleeding in patients with hypoproliferative thrombocytopenia. , 2012, Blood.

[52]  A. James,et al.  Postpartum hemorrhage: When uterotonics and sutures fail , 2012, American journal of hematology.

[53]  R. Cavallazzi,et al.  Central venous access sites for the prevention of venous thrombosis, stenosis and infection. , 2012, The Cochrane database of systematic reviews.

[54]  T. Barbui,et al.  Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[55]  A. Craig,et al.  Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. , 2010, Blood.

[56]  R. Palmiter,et al.  Cell-type-specific isolation of ribosome-associated mRNA from complex tissues , 2009, Proceedings of the National Academy of Sciences.

[57]  K. Wolff,et al.  The fibrin-derived peptide Bβ15–42 protects the myocardium against ischemia-reperfusion injury , 2005, Nature Medicine.

[58]  E. Samuelsson,et al.  Incidence of venous thromboembolism in young Swedish women and possibly preventable cases among combined oral contraceptive users , 2004, Acta obstetricia et gynecologica Scandinavica.

[59]  D. Altieri Regulation of Leukocyte-Endothelium Interaction by Fibrinogen , 1999, Thrombosis and Haemostasis.

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