Non-cytotoxic systemic treatment in malignant peripheral nerve sheath tumors (MPNST): A systematic review from bench to bedside.
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C. Verhoef | Y. Versleijen-Jonkers | I. Desar | E. Martin | J. H. Coert | N. Lamba | U. Flucke | J. Coert | Enrico Martin
[1] D. Liebler,et al. Fatty Acid , 2020, Definitions.
[2] L. Zheng,et al. Oncolytic Viruses and Their Application to Cancer Treatment , 2019, International Archives of Clinical Pharmacology.
[3] J. Connor,et al. MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors. , 2019, Journal of neurosurgery.
[4] A. Stemmer-Rachamimov,et al. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. , 2018, Cancer cell.
[5] Andrew A. Rooney,et al. Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies , 2018, PloS one.
[6] Franziska Michor,et al. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. , 2017, Cancer discovery.
[7] Robin L. Jones,et al. SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors , 2017, Sarcoma.
[8] Frank McCormick,et al. RAS Proteins and Their Regulators in Human Disease , 2017, Cell.
[9] J. Blay,et al. Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial. , 2017, The Lancet. Oncology.
[10] J. Chernoff,et al. Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1. , 2017, Biochimie.
[11] A. Lazar,et al. Targeting Group I p21-Activated Kinases to Control Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis , 2017, Oncogene.
[12] G. Schwartz,et al. Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin , 2017, Clinical Cancer Research.
[13] N. Ratner,et al. Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation , 2017, Oncotarget.
[14] N. Ishiguro,et al. Antitumor effects of 4‐methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor , 2017, International journal of cancer.
[15] A. Look,et al. Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors , 2016, Oncogene.
[16] Robin L. Jones,et al. SARC 006 : Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors , 2017 .
[17] Elizabeth E. Sweeney,et al. Photothermal therapy improves the efficacy of a MEK inhibitor in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors , 2016, Scientific Reports.
[18] D. Lev,et al. Verticillin A Inhibits Leiomyosarcoma and Malignant Peripheral Nerve Sheath Tumor Growth via Induction of Apoptosis , 2016, Clinical & experimental pharmacology.
[19] G. Schwartz,et al. Phase II study of MLN8237 (Alisertib) in advanced/metastatic sarcoma. , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.
[20] D. Largaespada,et al. CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin , 2016, Oncotarget.
[21] E. Legius,et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. , 2016, The Journal of clinical investigation.
[22] S. Steinberg,et al. SARC016: Phase II study of everolimus in combination with bevacizumab in sporadic and neurofibromatosis type 1 (NF1) related refractory malignant peripheral nerve sheath tumors (MPNST). , 2016 .
[23] Dafydd G. Thomas,et al. SARC009: Phase 2 study of dasatinib in patients with previously treated, high‐grade, advanced sarcoma , 2016, Cancer.
[24] F. Bertucci,et al. Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO). , 2016, European journal of cancer.
[25] Kai Huang,et al. Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor , 2016, Cancer biology & therapy.
[26] N. Ratner,et al. Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. , 2015, Neuro-oncology.
[27] A. Carnero,et al. Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA , 2015, Oncotarget.
[28] G. Schwartz,et al. Inhibition of polo like kinase 1 in sarcomas induces apoptosis that is dependent on Mcl-1 suppression , 2015, Cell cycle.
[29] R. Pollock,et al. HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST) , 2015, PloS one.
[30] D. Babovic‐Vuksanovic,et al. Oncolytic measles virus as a novel therapy for malignant peripheral nerve sheath tumors. , 2015, Gene.
[31] X. Puente,et al. Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine , 2015, EMBO molecular medicine.
[32] A. Kim,et al. Current Treatment Options for Malignant Peripheral Nerve Sheath Tumors , 2015, Current Treatment Options in Oncology.
[33] A. Lazar,et al. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway , 2015, Molecular Cancer.
[34] K. Camphausen,et al. Radiation Therapy in Management of Sporadic and Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors , 2014, Front. Oncol..
[35] J. F. Longo,et al. Combinatorial Therapy With Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades , 2014, Journal of neuropathology and experimental neurology.
[36] Eric Legius,et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies , 2014, Nature.
[37] O. Maertens,et al. Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers. , 2014, Cancer discovery.
[38] A. Kuramochi,et al. Translationally Controlled Tumor Protein Is a Novel Biological Target for Neurofibromatosis Type 1-associated Tumors* , 2014, The Journal of Biological Chemistry.
[39] R. Martuza,et al. Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus. , 2014, Neuro-oncology.
[40] C. Breitbach,et al. Going viral with cancer immunotherapy , 2014, Nature Reviews Cancer.
[41] G. Schwartz,et al. Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs , 2014, Clinical Cancer Research.
[42] J. Blay,et al. Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. , 2014, The Lancet. Oncology.
[43] S. Rabkin,et al. Oncolytic Viruses and Their Application to Cancer Immunotherapy , 2014, Cancer Immunology Research.
[44] G. Riggins,et al. Preclinical evaluation of the combination of mTOR and proteasome inhibitors with radiotherapy in malignant peripheral nerve sheath tumors , 2014, Journal of Neuro-Oncology.
[45] N. M. Powell,et al. Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity , 2014, Oncotarget.
[46] C. Liao,et al. BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. , 2014, Cell reports.
[47] M. Ghert,et al. Lost in translation: animal models and clinical trials in cancer treatment. , 2014, American journal of translational research.
[48] A. Stemmer-Rachamimov,et al. EGFR–STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors , 2014, Oncogene.
[49] A. Kurtz,et al. Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs) , 2013, Journal of Neuro-Oncology.
[50] L. Zelek,et al. Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review , 2013, Orphanet Journal of Rare Diseases.
[51] Jeffrey K. Mito,et al. NF1 Deletion Generates Multiple Subtypes of Soft-Tissue Sarcoma That Respond to MEK Inhibition , 2013, Molecular Cancer Therapeutics.
[52] I. Bièche,et al. MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis , 2013, BMC Genomics.
[53] N. Rosen,et al. ERK pathway inhibitors: how low should we go? , 2013, Cancer discovery.
[54] C. Creighton,et al. CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors , 2013, Cell.
[55] G. Page,et al. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. , 2013, The Journal of clinical investigation.
[56] J. Keats,et al. Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition , 2013, Oncotarget.
[57] Y. Yamashita,et al. Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β , 2013, BMC Cancer.
[58] Y. Iwamoto,et al. Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors , 2012, Clinical Cancer Research.
[59] M. Zhang,et al. Effect of Triptolide on Malignant Peripheral Nerve Sheath Tumours In Vitro and In Vivo , 2012, The Journal of international medical research.
[60] B. Aronow,et al. Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target , 2012, Clinical Cancer Research.
[61] J. Blay,et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial , 2012, The Lancet.
[62] D. Cooper,et al. Microarray‐based copy number analysis of neurofibromatosis type‐1 (NF1)‐associated malignant peripheral nerve sheath tumors reveals a role for Rho–GTPase pathway genes in NF1 tumorigenesis , 2012, Human mutation.
[63] C. Creighton,et al. Survivin Is a Viable Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors , 2012, Clinical Cancer Research.
[64] B. Pockaj,et al. Malignant Peripheral Nerve Sheath Tumors (MPNST): The Mayo Clinic Experience , 2012, Annals of Surgical Oncology.
[65] T. de Ravel,et al. Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors , 2011, Genes, chromosomes & cancer.
[66] Kwok-Kin Wong,et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. , 2011, Cancer cell.
[67] Jun Liu,et al. Activated MET Is a Molecular Prognosticator and Potential Therapeutic Target for Malignant Peripheral Nerve Sheath Tumors , 2011, Clinical Cancer Research.
[68] L. Mariani,et al. Non-metastatic unresected paediatric non-rhabdomyosarcoma soft tissue sarcomas: results of a pooled analysis from United States and European groups. , 2011, European journal of cancer.
[69] J. Kappes,et al. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner. , 2011, Neuro-oncology.
[70] A. Lazar,et al. Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors. , 2011, Cancer research.
[71] M. van Glabbeke,et al. First-line chemotherapy for malignant peripheral nerve sheath tumor (MPNST) versus other histological soft tissue sarcoma subtypes and as a prognostic factor for MPNST: an EORTC soft tissue and bone sarcoma group study. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.
[72] B. Aronow,et al. Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine‐positive tumors , 2010, The journal of gene medicine.
[73] K. Reilly,et al. The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. , 2010, Cancer research.
[74] Paul A Meyers,et al. Phase II multicenter trial of imatinib in 10 histologic subtypes of sarcoma using a bayesian hierarchical statistical model. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[75] L. Qin,et al. Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[76] Wei-Lien Wang,et al. Clinical, Pathological, and Molecular Variables Predictive of Malignant Peripheral Nerve Sheath Tumor Outcome , 2009, Annals of surgery.
[77] Shanta M. Messerli,et al. CAPE (caffeic acid phenethyl ester)‐based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice , 2009, Phytotherapy research : PTR.
[78] B. Aronow,et al. Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication , 2008, Cancer Gene Therapy.
[79] H. Lane,et al. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors , 2008, Molecular Cancer Therapeutics.
[80] J. Clegg,et al. Management and Prognosis , 2008 .
[81] Joseph Zeidner,et al. The pediatric preclinical testing program: Description of models and early testing results , 2007, Pediatric blood & cancer.
[82] T. Crombleholme,et al. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[83] H. Fukuhara,et al. Oncolytic HSV armed with platelet factor 4, an antiangiogenic agent, shows enhanced efficacy. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[84] H. Fukuhara,et al. Dominant-Negative Fibroblast Growth Factor Receptor Expression Enhances Antitumoral Potency of Oncolytic Herpes Simplex Virus in Neural Tumors , 2006, Clinical Cancer Research.
[85] C. Mussi,et al. Malignant peripheral nerve sheath tumors , 2006, Cancer.
[86] G. T. Budd,et al. Phase II study of erlotinib in metastatic or unresectable malignant peripheral nerve sheath tumors (MPNST). , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[87] T. Nheu,et al. Sichuan pepper extracts block the PAK1/Cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice , 2006, Cancer biology & therapy.
[88] O. Fain. [Neurofibromatosis type I]. , 2006, La Revue du praticien.
[89] A. Ferrari,et al. Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[90] G. Mashour,et al. Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids , 2005, Oncogene.
[91] A. Kurtz,et al. Signal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228 , 2005, Cancer biology & therapy.
[92] S. Velasco-Miguel,et al. Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. , 2002, Cancer research.
[93] Mohsen Farahani,et al. Photothermal therapy , 2002, Other Conferences.
[94] L. Kluwe,et al. Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas. , 1999, Cancer genetics and cytogenetics.
[95] E. Sausville,et al. US-NCI Testing Procedures , 1999 .
[96] B. Scheithauer,et al. Malignant peripheral nerve sheath tumor: analysis of treatment outcome. , 1998, International journal of radiation oncology, biology, physics.
[97] H. Niitani,et al. [Phase II study]. , 1995, Gan to kagaku ryoho. Cancer & chemotherapy.
[98] P. Marynen,et al. TP53 mutations are frequent in malignant NFI tumors , 1994, Genes, chromosomes & cancer.
[99] F. Collins,et al. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients , 1992, Nature.
[100] B. Scheithauer,et al. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases , 1986, Cancer.