Targeting Metalloproteins by Fragment‐Based Lead Discovery
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Seth M. Cohen | A. Strongin | A. Osterman | M. Pellecchia | E. Barile | Jun Wei | Ziming Zhang | I. Rodionova | B. Farina | S. Shiryaev | Sherida L. Johnson | A. Agrawal | Li-Hsing Chen | Angela Purves
[1] Seth M Cohen,et al. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. , 2011, Journal of medicinal chemistry.
[2] A. Strongin,et al. Biochemical Characterization of the Cellular Glycosylphosphatidylinositol-linked Membrane Type-6 Matrix Metalloproteinase* , 2010, The Journal of Biological Chemistry.
[3] Seth M. Cohen,et al. Chelator Fragment Libraries for Targeting Metalloproteinases , 2010, ChemMedChem.
[4] Wendy A. Warr,et al. Fragment-based drug discovery , 2009, J. Comput. Aided Mol. Des..
[5] M. Rowley,et al. Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model. , 2009, Bioorganic & medicinal chemistry letters.
[6] M. Pellecchia,et al. Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors. , 2009, Bioorganic & medicinal chemistry.
[7] Yuchen Cao,et al. Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship. , 2009, Bioorganic & medicinal chemistry letters.
[8] B. Shoichet,et al. Molecular docking and ligand specificity in fragment-based inhibitor discovery. , 2009, Nature chemical biology.
[9] Brett A Tounge,et al. Ligand efficiency and fragment-based drug discovery. , 2009, Drug discovery today.
[10] J Andrew McCammon,et al. Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor. , 2009, Journal of medicinal chemistry.
[11] Harald Schwalbe,et al. Perspectives on NMR in drug discovery: a technique comes of age , 2008, Nature Reviews Drug Discovery.
[12] Seth M Cohen,et al. Zinc‐Binding Groups Modulate Selective Inhibition of MMPs , 2008, ChemMedChem.
[13] Jong Yup Kim,et al. Convenient Total Synthesis of Taranabant (MK-0364), a Novel Cannabinoid-1 Receptor Inverse Agonist as an anti-Obesity Agent. , 2008 .
[14] A. Strongin,et al. Rhodanine Derivatives as Selective Protease Inhibitors Against Bacterial Toxins , 2008, Chemical biology & drug design.
[15] A. Osterman,et al. Glycerate 2-Kinase of Thermotoga maritima and Genomic Reconstruction of Related Metabolic Pathways , 2007, Journal of bacteriology.
[16] D. Fattori,et al. Fragment-Based Approach to Drug Lead Discovery , 2008, Drugs in R&D.
[17] C. Meier,et al. A New Short and Efficient Synthetic Route to C8-N-Acetylarylamine 2'-Deoxyguanosine Phosphoramidites , 2007 .
[18] Jan Schultz,et al. Integration of fragment screening and library design. , 2007, Drug discovery today.
[19] Glyn Williams,et al. Fragment-based screening using X-ray crystallography and NMR spectroscopy. , 2007, Current opinion in chemical biology.
[20] A. Kral,et al. Design of novel histone deacetylase inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[21] P. Hajduk,et al. A decade of fragment-based drug design: strategic advances and lessons learned , 2007, Nature Reviews Drug Discovery.
[22] Seth M Cohen,et al. The Design of Inhibitors for Medicinally Relevant Metalloproteins , 2007, ChemMedChem.
[23] M. Pellecchia,et al. A high-throughput screening approach to anthrax lethal factor inhibition. , 2006, Bioorganic chemistry.
[24] B. Déprez,et al. A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. , 2007, Bioorganic & medicinal chemistry.
[25] Maurizio Pellecchia,et al. Structure–activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid , 2006, Proceedings of the National Academy of Sciences.
[26] A. Khlebnikov,et al. Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. , 2006, Journal of medicinal chemistry.
[27] M. Uttamchandani,et al. Rapid assembly of matrix metalloprotease inhibitors using click chemistry. , 2006, Organic letters.
[28] Seth M Cohen,et al. A new role for old ligands: discerning chelators for zinc metalloproteinases. , 2006, Journal of the American Chemical Society.
[29] H. Mori,et al. Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. , 2006, DNA research : an international journal for rapid publication of reports on genes and genomes.
[30] D. Crick,et al. 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis: towards Understanding Mycobacterial Resistance to Fosmidomycin , 2005, Journal of bacteriology.
[31] John A. Young,et al. Receptor-specific requirements for anthrax toxin delivery into cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[32] Edgar Jacoby,et al. Library design for fragment based screening. , 2005, Current topics in medicinal chemistry.
[33] Steve Price,et al. Solid-phase synthesis of N-formylhydroxylamines (reverse/retro-hydroxamates). , 2005, Organic letters.
[34] Christopher W Murray,et al. Fragment-based lead discovery: leads by design. , 2005, Drug discovery today.
[35] E. Scolnick,et al. Anthrax lethal factor inhibition , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[36] Phillip Gribbon,et al. High-throughput drug discovery: what can we expect from HTS? , 2005, Drug discovery today.
[37] Daniel Delorme,et al. Novel hydroxamate and anilide derivatives as potent histone deacetylase inhibitors: synthesis and antiproliferative evaluation. , 2003, Current medicinal chemistry.
[38] K. Glaser,et al. Histone deacetylase inhibitors: the Abbott experience. , 2003, Current medicinal chemistry.
[39] M. Congreve,et al. A 'rule of three' for fragment-based lead discovery? , 2003, Drug discovery today.
[40] G. Giacomelli,et al. Simple one-flask method for the preparation of hydroxamic acids. , 2003, Organic letters.
[41] Jordi Mestres,et al. Identification of "latent hits" in compound screening collections. , 2003, Journal of medicinal chemistry.
[42] John Ellingboe,et al. Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. , 2003, Journal of medicinal chemistry.
[43] Yan Guo,et al. NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability. , 2002, Journal of medicinal chemistry.
[44] S. Schreiber,et al. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. , 2001, Organic letters.
[45] G. Ciszewski,et al. Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases. , 2001, Journal of medicinal chemistry.
[46] S. Davidsen,et al. Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors. , 2001, Bioorganic & medicinal chemistry letters.
[47] Andrew R. Leach,et al. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery , 2001, J. Chem. Inf. Comput. Sci..
[48] C. Supuran,et al. Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. , 2000, Journal of medicinal chemistry.
[49] Shunji Takahashi,et al. Characterization of 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase, an Enzyme Involved in Isopentenyl Diphosphate Biosynthesis, and Identification of Its Catalytic Amino Acid Residues* , 2000, The Journal of Biological Chemistry.
[50] I. Kuntz,et al. The maximal affinity of ligands. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[51] Shunji Takahashi,et al. Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis , 1998 .
[52] A. Butler,et al. Acquisition and utilization of transition metal ions by marine organisms. , 1998, Science.
[53] P. Hajduk,et al. Discovering High-Affinity Ligands for Proteins: SAR by NMR , 1996, Science.
[54] R. D. Dyer,et al. Hydroxamic acid inhibitors of 5-lipoxygenase. , 1987, Journal of medicinal chemistry.
[55] J. Clemens,et al. Synthesis of D-oxa tricyclic partial ergolines as dopamine agonists. , 1987, Journal of medicinal chemistry.
[56] M. D. Corbett,et al. Reaction of nitroso aromatics with glyoxylic acid. A new path to hydroxamic acids , 1980 .