Core Symptoms of Autism Improved After Vitamin D Supplementation

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder caused by a complex interaction between genetic and environmental risk factors. Among the environmental factors, vitamin D3 (cholecaliferol) seems to play a significant role in the etiology of ASD because this vitamin is important for brain development. Lower concentrations of vitamin D3 may lead to increased brain size, altered brain shape, and enlarged ventricles, which have been observed in patients with ASD. Vitamin D3 is converted into 25-hydroxyvitamin D3 in the liver. Higher serum concentrations of this steroid may reduce the risk of autism. Importantly, children with ASD are at an increased risk of vitamin D deficiency, possibly due to environmental factors. It has also been suggested that vitamin D3 deficiency may cause ASD symptoms. Here, we report on a 32-month-old boy with ASD and vitamin D3 deficiency. His core symptoms of autism improved significantly after vitamin D3 supplementation. This case suggests that vitamin D3 may play an important role in the etiology of ASD, stressing the importance of clinical assessment of vitamin D3 deficiency and the need for vitamin D3 supplementation in case of deficiency.

[1]  Z. Clemens,et al.  Alexithymia is associated with low level of vitamin D in young healthy adults , 2014, Nutritional neuroscience.

[2]  Kathryn Roeder,et al.  Most genetic risk for autism resides with common variation , 2014, Nature Genetics.

[3]  P. Curatolo,et al.  Are caesarean sections, induced labor and oxytocin regulation linked to Autism Spectrum Disorders? , 2014, Medical hypotheses.

[4]  Roberto Sacco,et al.  Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis , 2014, European Neuropsychopharmacology.

[5]  B. Ames,et al.  Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  C. Hultman,et al.  The familial risk of autism. , 2014, JAMA.

[7]  E. Susser,et al.  Parental Obesity and Risk of Autism Spectrum Disorder , 2014, Pediatrics.

[8]  A. Sjölander,et al.  Paternal age at childbearing and offspring psychiatric and academic morbidity. , 2014, JAMA psychiatry.

[9]  G. Baird,et al.  The Association Between Social Cognition and Executive Functioning and Symptoms of Anxiety and Depression in Adolescents With Autism Spectrum Disorders , 2014, Autism research : official journal of the International Society for Autism Research.

[10]  W. Brown,et al.  Autoantibodies against neuronal progenitors in sera from children with autism , 2014, Brain and Development.

[11]  A. Preti,et al.  Oxytocin and autism: a systematic review of randomized controlled trials. , 2014, Journal of child and adolescent psychopharmacology.

[12]  F. Jia,et al.  [Relationship between vitamin D and autism spectrum disorder]. , 2013, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

[13]  J. Cannell.  Autism, will vitamin D treat core symptoms? , 2013, Medical hypotheses.

[14]  M. Holick,et al.  Vitamin D for health: a global perspective. , 2013, Mayo Clinic proceedings.

[15]  G. I. Gallicano,et al.  Epigenetic Factors and Autism Spectrum Disorders , 2013, NeuroMolecular Medicine.

[16]  W. Grant,et al.  Autism prevalence in the United States with respect to solar UV-B doses , 2013, Dermato-endocrinology.

[17]  W. Grant,et al.  What is the role of vitamin D in autism? , 2013, Dermato-endocrinology.

[18]  C. Mathieu,et al.  Vitamin D: a pleiotropic hormone. , 2010, Kidney international.

[19]  W. Grant,et al.  Epidemiologic evidence for supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism , 2009, Dermato-endocrinology.

[20]  F. Montecchi,et al.  Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC) Correspondence and Conflicts with DSM-IV Criteria in Diagnosis of Autism , 2004, Journal of autism and developmental disorders.

[21]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[22]  J. Fleiss,et al.  The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. , 1976, Archives of general psychiatry.

[23]  S. Fereshtehnejad,et al.  Association of serum 25(OH) vitamin D3 concentration with severity of multiple sclerosis , 2012, Iranian journal of neurology.

[24]  J. Cannell,et al.  Autism and vitamin D. , 2008, Medical hypotheses.

[25]  Rating scales and assessment instruments for use in pediatric psychopharmacology research. , 1985, Psychopharmacology bulletin.