Regulation of the cerebral circulation: role of endothelium and potassium channels.

Several new concepts have emerged in relation to mechanisms that contribute to regulation of the cerebral circulation. This review focuses on some physiological mechanisms of cerebral vasodilatation and alteration of these mechanisms by disease states. One mechanism involves release of vasoactive factors by the endothelium that affect underlying vascular muscle. These factors include endothelium-derived relaxing factor (nitric oxide), prostacyclin, and endothelium-derived hyperpolarizing factor(s). The normal vasodilator influence of endothelium is impaired by some disease states. Under pathophysiological conditions, endothelium may produce potent contracting factors such as endothelin. Another major mechanism of regulation of cerebral vascular tone relates to potassium channels. Activation of potassium channels appears to mediate relaxation of cerebral vessels to diverse stimuli including receptor-mediated agonists, intracellular second messenger, and hypoxia. Endothelial- and potassium channel-based mechanisms are related because several endothelium-derived factors produce relaxation by activation of potassium channels. The influence of potassium channels may be altered by disease states including chronic hypertension, subarachnoid hemorrhage, and diabetes.

[1]  N. Boéchat,et al.  Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis , 1996, The Journal of experimental medicine.

[2]  C. Garland,et al.  Smooth muscle hyperpolarization and relaxation to acetylcholine in the rabbit basilar artery. , 1994, Journal of the autonomic nervous system.

[3]  K. Schror,et al.  Nitric Oxide Is the Endothelium‐Derived Relaxing Factor in Bovine Pial Arterioles , 1990, Stroke.

[4]  U. Dirnagl,et al.  Microvascular Changes during the Early Phase of Experimental Bacterial Meningitis , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[5]  F. Marumo,et al.  Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells. , 1994, The Journal of clinical investigation.

[6]  J. Nishimura,et al.  Dual regulation of cerebrovascular tone by UTP: P2U receptor‐mediated contraction and endothelium‐dependent relaxation , 1996, British journal of pharmacology.

[7]  D. Busija,et al.  Interaction between ATP-Sensitive K+ Channels and Nitric Oxide on Pial Arterioles in Piglets , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  A. Planas,et al.  Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain , 1995, Neuroscience Letters.

[9]  M. Creager,et al.  Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. , 1996, Hypertension.

[10]  J. Povlishock,et al.  Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. , 1980, Science.

[11]  C. Epstein,et al.  Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. , 1993, Neuroreport.

[12]  H. Kontos George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. , 1985, Circulation research.

[13]  K. Robinson,et al.  Homocysteine and coronary atherosclerosis. , 1996, Journal of the American College of Cardiology.

[14]  R. Albrecht,et al.  The Role of Neuronal Nitric Oxide Synthase in Regulation of Cerebral Blood Flow in Normocapnia and Hypercapnia in Rats , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  T. Lincoln,et al.  Cyclic GMP and mechanisms of vasodilation. , 1989, Pharmacology & therapeutics.

[16]  W. Rosenblum Effects of free radical generation on mouse pial arterioles: probable role of hydroxyl radicals. , 1983, The American journal of physiology.

[17]  H. Kontos,et al.  Superoxide production in experimental brain injury. , 1986, Journal of neurosurgery.

[18]  A. Miyamoto,et al.  Endothelial modulation of vascular tone in isolated porcine and bovine basilar arteries. , 1994, The Journal of veterinary medical science.

[19]  A. A. Parsons,et al.  Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression , 1994, Brain Research.

[20]  M. Wong,et al.  Localization of Interleukin-1βP Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels , 1995 .

[21]  Z. Katušić Endothelial L-arginine pathway and regional cerebral arterial reactivity to vasopressin. , 1992, The American journal of physiology.

[22]  C. Leffler,et al.  Dilator prostanoid-induced cyclic AMP formation and release by cerebral microvascular smooth muscle cells: inhibition by indomethacin. , 1995, The Journal of pharmacology and experimental therapeutics.

[23]  J. D. Elliott,et al.  California dreamin' 'bout endothelin: emerging new therapeutics. , 1996, Trends in pharmacological sciences.

[24]  K. Hirata,et al.  Augmented receptor-mediated Ca2+ mobilization causes supersensitivity of contractile response to serotonin in atherosclerotic arteries. , 1994, Circulation research.

[25]  J. Mcculloch,et al.  Modification of Vasoconstrictor Responses in Cerebral Blood Vessels by Lesioning of The Trigeminal Nerve: Possible Involvement of CGRP , 1995, Cephalalgia : an international journal of headache.

[26]  S. Murphy,et al.  Astrocyte‐derived lipoxygenase product evokes endothelium‐dependent relaxation of the basilar artery , 1994, Journal of neuroscience research.

[27]  P. Libby,et al.  Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. , 1995, The Journal of clinical investigation.

[28]  F. J. Romero,et al.  4-Hydroxynonenal, a Lipid Peroxidation Product, Induces Relaxation of Human Cerebral Arteries , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[29]  S. Moncada,et al.  Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo , 1990, British journal of pharmacology.

[30]  H. Ehrenreich,et al.  Endothelin-Induced Contraction and Relaxation of Rat Isolated Basilar Artery: Effect of BQ-123 , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[31]  J. Povlishock,et al.  Recovery of impaired endothelium-dependent relaxation after fluid-percussion brain injury in cats. , 1989, Stroke.

[32]  G. Bilbe,et al.  Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression. , 1994, Biochimica et biophysica acta.

[33]  D. Heistad,et al.  Ionic mechanisms in spontaneous vasomotion of the rat basilar artery in vivo. , 1990, The Journal of physiology.

[34]  H. Toda,et al.  Vasodilative effect of adrenomedullin in isolated arteries of the dog. , 1995, Japanese journal of pharmacology.

[35]  M. Lauritzen,et al.  Examination of the role of nitric oxide for the hypercapnic rise of cerebral blood flow in rats. , 1994, The American journal of physiology.

[36]  S. Scherer,et al.  Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. , 1993, The Journal of biological chemistry.

[37]  K. Einhäupl,et al.  Angiotensin degradation products mediate endothelium-dependent dilation of rabbit brain arterioles. , 1991, Circulation research.

[38]  F. Marumo,et al.  Molecular cloning of endothelial, inducible nitric oxide synthase gene from rat aortic endothelial cell. , 1996, European journal of biochemistry.

[39]  M. Moskowitz,et al.  ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. , 1996, The American journal of physiology.

[40]  W. Rosenblum,et al.  Antisense evidence for two functionally active forms of nitric oxide synthase in brain microvascular endothelium. , 1996, Biochemical and biophysical research communications.

[41]  A. Casadevall,et al.  Human astrocytes inhibit Cryptococcus neoformans growth by a nitric oxide-mediated mechanism , 1994, The Journal of experimental medicine.

[42]  K. Sugita,et al.  Increased Ca2+ Influx in the Resting State Maintains the Myogenic Tone and Activates Charybdotoxin-Sensitive K+ Channels in Dog Basilar Artery , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[43]  N. Aiyar,et al.  Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Cox,et al.  Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis. , 1996, Pharmacological reviews.

[45]  W. Mayhan Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus , 1992, Brain Research.

[46]  W. Mayhan Responses of Cerebral Arterioles to Activation of β‐Adrenergic Receptors During Diabetes Mellitus , 1994, Stroke.

[47]  P. Black,et al.  L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. , 1991, The Journal of clinical investigation.

[48]  W. Mayhan Responses of the basilar artery to products released by platelets during chronic hypertension , 1991, Brain Research.

[49]  J. Mcculloch,et al.  Journal of Cerebral Blood Flow and Metabolism Endothelin-mediated Vascular Tone following Focal Cerebral Ischaemia in the Cat , 2022 .

[50]  F. Dai,et al.  Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. , 1994, The American journal of physiology.

[51]  F. Lang,et al.  Effects of H2O2 on membrane potential and [Ca2+]i of cultured rat arterial smooth muscle cells. , 1995, Biochemical and biophysical research communications.

[52]  M. Aldasoro,et al.  Influence of Endothelial Nitric Oxide on Adrenergic Contractile Responses of Human Cerebral Arteries , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[53]  K. Hongo,et al.  Subarachnoid hemorrhage inhibition of endothelium-derived relaxing factor in rabbit basilar artery. , 1988, Journal of neurosurgery.

[54]  Z. Katušić,et al.  Superoxide anion and endothelial regulation of arterial tone. , 1991, Seminars in perinatology.

[55]  W. Mayhan Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension. , 1992, The American journal of physiology.

[56]  P. Pratt,et al.  Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. , 1996, Circulation research.

[57]  R. Cohen,et al.  Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle , 1994, Nature.

[58]  D. Choi,et al.  Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS , 1994, Neuron.

[59]  F. Murad,et al.  Cyclic GMP synthesis and function. , 1987, Pharmacological reviews.

[60]  Y. Yamamoto,et al.  Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. , 1991, The American journal of physiology.

[61]  R M Nerem,et al.  Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. , 1992, The Journal of clinical investigation.

[62]  S. Baumgartner-Parzer,et al.  High-glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or of endothelial NO synthase. , 1996, The Biochemical journal.

[63]  M. Takayasu,et al.  Vasorelaxant effect of PACAP-27 on canine cerebral arteries and rat intracerebral arterioles. , 1995, European journal of pharmacology.

[64]  D. Harrison,et al.  Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide , 1990, Nature.

[65]  W. Meng,et al.  Calcitonin gene-related peptide promotes cerebrovascular dilation during cortical spreading depression in rabbits. , 1994, The American journal of physiology.

[66]  C. Nathan,et al.  Regulation of biosynthesis of nitric oxide. , 1994, The Journal of biological chemistry.

[67]  M. Todd,et al.  The Dose‐related Effects of Nitric Oxide Synthase Inhibition on Cerebral Blood Flow during Isoflurane and Pentobarbital Anesthesia , 1994, Anesthesiology.

[68]  H. Takeuchi,et al.  The correlation between immunological reaction in the arterial wall and the time course of the development of cerebral vasospasm in a primate model. , 1991, Neurosurgery.

[69]  T. Hinterleitner,et al.  IL-1 stimulates intestinal myofibroblast COX gene expression and augments activation of Cl- secretion in T84 cells. , 1996, The American journal of physiology.

[70]  S. Tokudome,et al.  Investigation of Postmortem Functional Changes in Human Cerebral Arteries , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[71]  D. Reis,et al.  Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation* , 1996, The Journal of Biological Chemistry.

[72]  M. Nelson,et al.  Regulation of membrane potential and diameter by voltage-dependent K+ channels in rabbit myogenic cerebral arteries. , 1995, The American journal of physiology.

[73]  I. Charles,et al.  Altered immune responses in mice lacking inducible nitric oxide synthase , 1995, Nature.

[74]  M. Moskowitz,et al.  Oxygen radicals in cerebral ischemia. , 1992, The American journal of physiology.

[75]  W. Meng,et al.  Nitric Oxide Promotes Arteriolar Dilation During Cortical Spreading Depression in Rabbits , 1994, Stroke.

[76]  S. Ibayashi,et al.  Age-related changes in response of brain stem vessels to opening of ATP-sensitive potassium channels. , 1997, Stroke.

[77]  M. Takayasu,et al.  Role of Nitric Oxide in the Cerebral Vasodilatory Responses to Vasopressin and Oxytocin in Dogs , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[78]  M. Yacoub,et al.  Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries , 1990, The Lancet.

[79]  A. A. Parsons,et al.  Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery , 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

[80]  M. Yakubu,et al.  Role of endothelin-1 in cerebral hematoma-induced modification of cerebral vascular reactivity in piglets , 1996, Brain Research.

[81]  T. Kitazono,et al.  Role of potassium channels in cerebral blood vessels. , 1995, Stroke.

[82]  K. Hirata,et al.  Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation. , 1996, The American journal of pathology.

[83]  H. Suzuki,et al.  Calcium dependency of the endothelium‐dependent hyperpolarization in smooth muscle cells of the rabbit carotid artery. , 1990, The Journal of physiology.

[84]  C. Iadecola,et al.  Role of nitric oxide and acetylcholine in neocortical hyperemia elicited by basal forebrain stimulation: Evidence for an involvement of endothelial nitric oxide , 1995, Neuroscience.

[85]  T. Lüscher,et al.  Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. , 1990, The Journal of clinical investigation.

[86]  L. Edvinsson,et al.  Mechanisms of Action of Endothelin on Isolated Feline Cerebral Arteries: In vitro Pharmacology and Electrophysiology , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[87]  J. Mudgett,et al.  Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[88]  C. Sobey,et al.  Effect of short-term regression of atherosclerosis on reactivity of carotid and retinal arteries. , 1996, Stroke.

[89]  T Sandor,et al.  Differential impairment of vasodilator responsiveness of peripheral resistance and conduit vessels in humans with atherosclerosis. , 1991, Circulation research.

[90]  H. Esumi,et al.  Nitric oxide synthase expression in human neuroblastoma cell line induced by cytokines , 1996, Neuroreport.

[91]  M. Creager,et al.  Impaired Endothelium‐Dependent Vasodilation in Patients With Insulin‐Dependent Diabetes Mellitus , 1993, Circulation.

[92]  O. Smithies,et al.  Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[93]  C. W. Parker,et al.  Metabolites of arachidonic acid , 1983, Clinical reviews in allergy.

[94]  S. Moncada,et al.  Molecular mechanisms and therapeutic strategies related to nitric oxide , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[95]  K. Breese,et al.  Cerebral vasoconstrictor responses to serotonin after dietary treatment of atherosclerosis: implications for transient ischemic attacks. , 1987, Stroke.

[96]  S. Ueno,et al.  Isolation and Identification of Methylarginines from Bovine Brain , 1992, Journal of neurochemistry.

[97]  S. Kostyk,et al.  Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. , 1994, The American journal of physiology.

[98]  M. Kindy,et al.  Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain. , 1996, Brain research. Molecular brain research.

[99]  F. Faraci,et al.  Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels. , 1993, The American journal of physiology.

[100]  W. Sessa The nitric oxide synthase family of proteins. , 1994, Journal of vascular research.

[101]  A. Quyyumi,et al.  Impaired endothelium-dependent vascular relaxation in patients with hypercholesterolemia extends beyond the muscarinic receptor. , 1995, The American journal of cardiology.

[102]  Z. Katušić,et al.  Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery. , 1997, Circulation research.

[103]  A. Arthur,et al.  Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage. , 1996, Journal of neurosurgery.

[104]  O. Bagasra,et al.  Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[105]  T. Sakurai,et al.  Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor , 1990, Nature.

[106]  Z. Katušić,et al.  Endothelial L-arginine pathway and relaxations to vasopressin in canine basilar artery. , 1993, The American journal of physiology.

[107]  C. Leffler,et al.  Tumor necrosis factor-α induces pial arteriolar dilation in newborn pigs , 1996, Brain Research Bulletin.

[108]  M. Aldasoro,et al.  Role of endothelium and calcium channels in endothelin‐induced contraction of human cerebral arteries , 1990, British journal of pharmacology.

[109]  R. Dacey,et al.  Nitric Oxide Regulates Cerebral Arteriolar Tone in Rats , 1994, Stroke.

[110]  E. Ellis,et al.  Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. , 1990, The American journal of physiology.

[111]  S. Moncada,et al.  Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[112]  H. Pfister,et al.  Nitric oxide production in bacterial meningitis. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[113]  S. Harbon,et al.  Diverse prostaglandin receptors activate distinct signal transduction pathways in rat myometrium. , 1992, The American journal of physiology.

[114]  N. Ishida,et al.  Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells. , 1993, Biochemical and biophysical research communications.

[115]  W. Mayhan,et al.  Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. , 1991, The American journal of physiology.

[116]  M. Moskowitz,et al.  Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[117]  I. Georgoff,et al.  Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells. , 1994, Experimental cell research.

[118]  M. Harrison,et al.  Cyclo-oxygenase-2 Messenger RNA Induction in Focal Cerebral Ischemia , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[119]  M. Moskowitz,et al.  Trigeminovascular fibers increase blood flow in cortical gray matter by axon reflex-like mechanisms during acute severe hypertension or seizures. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[120]  T. Oury,et al.  Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[121]  N. Standen,et al.  Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels , 1990, Nature.

[122]  W. Rosenblum Endothelium‐Derived Relaxing Factor in Brain Blood Vessels Is Not Nitric Oxide , 1992, Stroke.

[123]  W. Armstead,et al.  Journal of Cerebral Blood Flow and Metabolism Cerebral Superoxide Anion Generation during Seizures in Newborn Pigs , 2022 .

[124]  Sadao Kimura,et al.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells , 1988, Nature.

[125]  W. Armstead,et al.  Blood-induced superoxide anion generation on the cerebral cortex of newborn pigs. , 1989, The American journal of physiology.

[126]  E. Kozniewska,et al.  Effects of Endothelium-Derived Nitric Oxide on Cerebral Circulation during Normoxia and Hypoxia in the Rat , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[127]  K. Kanamaru,et al.  The effect of atherosclerosis on endothelium-dependent relaxation in the aorta and intracranial arteries of rabbits. , 1989, Journal of neurosurgery.

[128]  M. Nelson,et al.  Physiological roles and properties of potassium channels in arterial smooth muscle. , 1995, The American journal of physiology.

[129]  W. Armstead Role of ATP-sensitive K+ channels in cGMP-mediated pial artery vasodilation. , 1996, The American journal of physiology.

[130]  A. Maseri,et al.  Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. , 1991, The New England journal of medicine.

[131]  R. Grove,et al.  Matrix-derived soluble components influence type II pneumocytes in primary culture. , 1989, The American journal of physiology.

[132]  R. Schrier,et al.  Upregulation of endothelial and neuronal constitutive nitric oxide synthase in pregnant rats. , 1996, The American journal of physiology.

[133]  T. Nagafuji,et al.  Temporal profiles of Ca2+/calmodulin-dependent and -independent nitric oxide synthase activity in the rat brain microvessels following cerebral ischemia. , 1994, Acta neurochirurgica. Supplementum.

[134]  P. Vanhoutte,et al.  Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. , 1986, The American journal of physiology.

[135]  C. Garland,et al.  Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery , 1993, British journal of pharmacology.

[136]  M. Moskowitz,et al.  L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice. , 1996, The American journal of physiology.

[137]  M. Reivich,et al.  Activated neutrophils inhibit cerebrovascular endothelium-dependent relaxations in vitro. , 1991, Life sciences.

[138]  M. Blaustein,et al.  NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[139]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[140]  R. Busse,et al.  Characterization of endothelium‐derived hyperpolarizing factor as a cytochrome P450‐derived arachidonic acid metabolite in mammals. , 1994, The Journal of physiology.

[141]  J. Merrill,et al.  Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain , 1995, The Journal of experimental medicine.

[142]  G. Yang,et al.  7-Nitroindazole attenuates vasodilation from cerebellar parallel fiber stimulation but not acetylcholine. , 1996, The American journal of physiology.

[143]  F. Abboud,et al.  Dickinson W. Richards Lecture: Circulatory adjustments to hypoxia. , 1980, Circulation.

[144]  L. Salkoff,et al.  A human calcium-activated potassium channel gene expressed in vascular smooth muscle. , 1995, The American journal of physiology.

[145]  J. Bevan,et al.  Barium inhibits the endothelium-dependent component of flow but not acetylcholine-induced relaxation in isolated rabbit cerebral arteries. , 1995, The Journal of pharmacology and experimental therapeutics.

[146]  S. Bode-Böger,et al.  Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. , 1996, Biochemical and biophysical research communications.

[147]  D. Harder,et al.  Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog. , 1987, The Journal of clinical investigation.

[148]  H. Kontos,et al.  Arginine analogues inhibit responses mediated by ATP-sensitive K+ channels. , 1996, The American journal of physiology.

[149]  H. Kuriyama,et al.  Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. , 1995, Pharmacological reviews.

[150]  R. Macdonald,et al.  A review of hemoglobin and the pathogenesis of cerebral vasospasm. , 1991, Stroke.

[151]  S. Naito,et al.  Nitric oxide synthase in cerebral ischemia. Possible contribution of nitric oxide synthase activation in brain microvessels to cerebral ischemic injury. , 1995, Molecular and chemical neuropathology.

[152]  R. Johns,et al.  Up‐regulation of endothelial nitric oxide synthase expression by cyclic guanosine 3′,5′‐monophosphate , 1995, FEBS letters.

[153]  J. Clement,et al.  Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. , 1995, Science.

[154]  N. Kassell,et al.  Reversal of subarachnoid hemorrhage-induced vasoconstriction with an endothelin receptor antagonist. , 1994, Neurosurgery.

[155]  D. Heistad,et al.  Effect of Carbon Monoxide on Rabbit Cerebral Arteries , 1994, Stroke.

[156]  R. Traystman,et al.  Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates. , 1995, Stroke.

[157]  S. Ohta,et al.  Role of basic fibroblast growth factor in the regulation of rat basilar artery tone in vivo , 1995, Neuroscience Letters.

[158]  R. Roman,et al.  Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. , 1994, The American journal of physiology.

[159]  R. Michler,et al.  L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. , 1997, Circulation.

[160]  W. S. Lee,et al.  Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation. , 1994, The American journal of physiology.

[161]  R. Brandes,et al.  Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits. , 1994, Journal of cardiovascular pharmacology.

[162]  S. Lipton,et al.  Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV- associated neurological disease , 1995, The Journal of experimental medicine.

[163]  M. Mizuguchi,et al.  Development of endothelial nitric oxide synthase in endothelial cells in the human cerebrum. , 1995, Brain research. Developmental brain research.

[164]  P G Anderson,et al.  Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. , 1994, Biological chemistry Hoppe-Seyler.

[165]  A. Sica,et al.  A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter , 1995, The Journal of experimental medicine.

[166]  J. Swales Clinical trials: what more is needed? A critical view , 1996, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[167]  K. Hirata,et al.  Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. , 1995, Circulation research.

[168]  K. Mccully Homocysteine and vascular disease , 1996, Nature Medicine.

[169]  I. Saito,et al.  Zygomatic temporopolar approach for basilar artery aneurysms , 1989 .

[170]  M. Nelson,et al.  Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries. , 1993, The American journal of physiology.

[171]  D. Strøbæk,et al.  Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[172]  M. Kimoto,et al.  Detection of NG,NGDimethylarginine Dimethylaminohydrolase in Human Tissues Using a Monoclonal Antibody , 1995 .

[173]  J. Milde,et al.  Subarachnoid Hemorrhage and Endothelial L‐Arginine Pathway in Small Brain Stem Arteries in Dogs , 1993, Stroke.

[174]  W. Meng,et al.  Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors. , 1995, Stroke.

[175]  H. Kontos,et al.  Superoxide Production in Experimental Seizures in Cats , 1992, Stroke.

[176]  R. Busse,et al.  Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. , 1994, Circulation research.

[177]  S. Leib,et al.  Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. , 1996, The Journal of clinical investigation.

[178]  J. Mcculloch,et al.  Effects on feline pial arterioles in situ of bosentan, a non-peptide endothelin receptor antagonist. , 1994, European journal of pharmacology.

[179]  K. Breese,et al.  Responses of Cerebral Arterioles to Kainate , 1994, Stroke.

[180]  S. Snyder,et al.  Localization of nitric oxide synthase indicating a neural role for nitric oxide , 1990, Nature.

[181]  F. Marumo,et al.  Regulation of inducible nitric oxide synthase gene by interleukin-1 beta in rat vascular endothelial cells. , 1994, The American journal of physiology.

[182]  M. Moskowitz,et al.  L-NA-Sensitive rCBF Augmentation during Vibrissal Stimulation in Type III Nitric Oxide Synthase Mutant Mice , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[183]  Hong Wang,et al.  Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells , 1994, Journal of neurochemistry.

[184]  E. Connolly,et al.  Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. , 1996, The Journal of clinical investigation.

[185]  J. Shepherd,et al.  Endothelium‐Derived Vasoactive Factors: I Endothelium‐Dependent Relaxation , 1991, Hypertension.

[186]  A M Zeiher,et al.  Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. , 1993, The Journal of clinical investigation.

[187]  A. Weintrob,et al.  Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats , 1995, Infection and immunity.

[188]  R. Paul,et al.  Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP. , 1986, The American journal of physiology.

[189]  D. Heistad,et al.  Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. , 1987, The American journal of physiology.

[190]  B. Davidson,et al.  Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue. , 1995, Circulation research.

[191]  R W McPherson,et al.  Hypoxia, alpha 2-adrenergic, and nitric oxide-dependent interactions on canine cerebral blood flow. , 1994, The American journal of physiology.

[192]  R. Sercombe,et al.  Endothelial Dysfunction in Cerebral Vessels following Carotid Artery Infusion of Phorbol Ester in Rabbits: The Role of Polymorphonuclear Leukocytes , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[193]  D. Harder,et al.  Altered membrane properties of cerebral vascular smooth muscle following subarachnoid hemorrhage: an electrophysiological study. I. Changes in resting membrane potential (Em) and effect on the electrogenic pump potential contribution to Em. , 1985, Stroke.

[194]  L. V. Van Eldik,et al.  S100β Stimulates Inducible Nitric Oxide Synthase Activity and mRNA Levels in Rat Cortical Astrocytes (*) , 1996, The Journal of Biological Chemistry.

[195]  K. Schappert,et al.  Molecular cloning and characterization of human endothelial nitric oxide synthase , 1992, FEBS letters.

[196]  I. Wakabayashi,et al.  Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. , 1990, Stroke.

[197]  R. Sercombe,et al.  Leukocyte-induced endothelial dysfunction in the rabbit basilar artery: modulation by platelet-activating factor. , 1995, Journal of lipid mediators and cell signalling.

[198]  R. Macdonald,et al.  Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkeys. , 1996, Stroke.

[199]  P. D. Henry,et al.  Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. , 1987, The Journal of clinical investigation.

[200]  T. Quertermous,et al.  Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase. , 1992, The Journal of biological chemistry.

[201]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[202]  P. Vanhoutte,et al.  Bioassay of endothelium-derived hyperpolarizing factor. , 1996, Biochemical and biophysical research communications.

[203]  N. Simionescu,et al.  The Cardiovascular System , 1983 .

[204]  J S Beckman,et al.  Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. , 1996, The American journal of physiology.

[205]  D. Cook,et al.  Mechanisms of cerebral vasospasm in subarachnoid haemorrhage. , 1995, Pharmacology & therapeutics.

[206]  H. Masaoka,et al.  RAISED PLASMA ENDOTHELIN IN ANEURYSMAL SUBARACHNOID HAEMORRHAGE , 1989, The Lancet.

[207]  S. Snyder,et al.  Targeted disruption of the neuronal nitric oxide synthase gene , 1993, Cell.

[208]  C. Nathan,et al.  Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. , 1994, The Journal of biological chemistry.

[209]  M. Ross,et al.  Inducible Nitric Oxide Synthase Gene Expression in Brain following Cerebral Ischemia , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[210]  H. Kontos,et al.  Effects in Cats of Inhibition of Nitric Oxide Synthesis on Cerebral Vasodilation and Endothelium‐Derived Relaxing Factor From Acetylcholine , 1992, Stroke.

[211]  M. Hecker,et al.  Etomidate and Thiopental Inhibit the Release of Endothelium‐derived Hyperpolarizing Factor in the Human Renal Artery , 1996, Anesthesiology.

[212]  D. Heistad,et al.  Effect of Diabetes Mellitus on Flow‐Mediated and Endothelium‐Dependent Dilatation of the Rat Basilar Artery , 1992, Stroke.

[213]  W. Mayhan,et al.  Acute effects of glucose on reactivity of cerebral microcirculation: role of activation of protein kinase C. , 1995, The American journal of physiology.

[214]  T. Yoshimoto,et al.  Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys. , 1996, Neurosurgery.

[215]  S. Ibayashi,et al.  l-Arginine ameliorates cerebral blood flow and metabolism and decreases infarct volume in rats with cerebral ischemia , 1995, Brain Research.

[216]  A. Sommer,et al.  Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. , 1995, Biological chemistry Hoppe-Seyler.

[217]  D. J. Wilkinson,et al.  Cholinergic modulation of apical Na+ channels in turtle colon: analysis of CDPC-induced fluctuations. , 1990, The American journal of physiology.

[218]  B. Brenner,et al.  Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha. , 1991, The American journal of physiology.

[219]  P. Hardy,et al.  Prostaglandin G/H Synthase-2 Is a Major Contributor of Brain Prostaglandins in the Newborn (*) , 1995, The Journal of Biological Chemistry.

[220]  F. Faraci,et al.  Regulation of the cerebral circulation by endothelium. , 1992, Pharmacology & therapeutics.

[221]  F. Faraci,et al.  7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilatation in response to N-methyl-D-aspartate. , 1995, Stroke.

[222]  M. Rubart,et al.  Relaxation of Arterial Smooth Muscle by Calcium Sparks , 1995, Science.

[223]  R. Cohen,et al.  Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. , 1990, The Journal of clinical investigation.

[224]  D. J. Wolff,et al.  Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase. , 1995, Archives of biochemistry and biophysics.

[225]  K. Nozaki,et al.  Ultrastructural localization and translocation of nitric oxide synthase in the endothelium of the human cerebral artery , 1995, Brain Research.

[226]  M. Mcdaniel,et al.  Selective inhibition of inducible nitric oxide synthase by aminoguanidine. , 1993, Methods in enzymology.

[227]  J. Loscalzo,et al.  Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. , 1990, The Journal of clinical investigation.

[228]  W. Mayhan Endothelium-dependent responses of cerebral arterioles to adenosine 5'-diphosphate. , 1992, Journal of vascular research.

[229]  A Villringer,et al.  Nitric oxide synthase blockade enhances vasomotion in the cerebral microcirculation of anesthetized rats. , 1993, Microvascular research.

[230]  G. Yadid,et al.  In Vivo Expression of Inducible Nitric Oxide Synthase in Cerebellar Neurons , 1996, Journal of neurochemistry.

[231]  T. Uehara,et al.  Herbimycin A suppresses NF‐κB activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells , 1995, FEBS letters.

[232]  K. Breese,et al.  Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. , 1993, Circulation research.

[233]  R. A. Murphy,et al.  Sr2+ activates cross-bridge phosphorylation and latch state in smooth muscle. , 1988, The American journal of physiology.

[234]  U. Dirnagl,et al.  Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis , 1995, Journal of Neuroimmunology.

[235]  K. Smith,et al.  Cerebrospinal fluid endothelin-1 and endothelin-3 levels in normal and neurosurgical patients: a clinical study and literature review. , 1991, Surgical neurology.

[236]  U. Dirnagl,et al.  Focoidin, a polysaccharide inhibiting leukocyte rolling, attenuates inflammatory responses in experimental pneumococcal meningitis in rats , 1995, Neuroscience Letters.

[237]  C. Alafaci,et al.  Enhanced vasoconstrictor effect of endothelin in cerebral arteries from rats with subarachnoid haemorrhage. , 1990, Acta physiologica Scandinavica.

[238]  J. Algren,et al.  The Effect of Nitrous Oxide on Laryngeal Mask Airway Volume and Pressure in Children , 1994 .

[239]  J. Liao,et al.  Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase (*) , 1995, The Journal of Biological Chemistry.

[240]  P. Zygmunt,et al.  Substance P‐induced relaxation and hyperpolarization in human cerebral arteries , 1995, British journal of pharmacology.

[241]  R. Macdonald,et al.  Increased Expression of Endothelin B Receptor mRNA following Subarachnoid Hemorrhage in Monkeys , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[242]  S. Roux,et al.  The role of endothelin in experimental cerebral vasospasm. , 1995, Neurosurgery.

[243]  K. Boje Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis , 1996, Brain Research.

[244]  N. Stockbridge,et al.  Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim. , 1992, General pharmacology.

[245]  M. D. Mossalayi,et al.  Nitric oxide production by human monocytes: evidence for a role of CD23. , 1995, Immunology today.

[246]  T. Lüscher,et al.  Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. , 1986, Hypertension.

[247]  S. Sakoda,et al.  Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis , 1995, Journal of Neuroimmunology.

[248]  M. Nelson,et al.  Extracellular K(+)‐induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. , 1996, The Journal of physiology.

[249]  D. Heistad,et al.  Responses of cerebral arterioles to N-methyl-d-aspartate and activation of ATP-sensitive potassium channels in old rats , 1994, Brain Research.

[250]  S. Yang Role of nitric oxide in the maintenance of resting cerebral blood flow during chronic hypertension. , 1996, Life sciences.

[251]  D. Heistad,et al.  Role of Ca(2+)-dependent K+ channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat. , 1996, Stroke.

[252]  M. Kimoto,et al.  Detection of NG,NG-dimethylarginine dimethylaminohydrolase in the nitric oxide-generating systems of rats using monoclonal antibody. , 1993, Archives of biochemistry and biophysics.

[253]  Mark A. Weih,et al.  Pneumococcal cell wall components induce nitric oxide synthase and TNF‐α in astroglial‐enriched cultures , 1996, Glia.

[254]  K. Breese,et al.  Effect of atherosclerosis on cerebral vascular responses to activation of leukocytes and platelets in monkeys. , 1991, Stroke.

[255]  M. Moskowitz,et al.  L-Arginine Infusion Promotes Nitric Oxide-Dependent Vasodilation, Increases Regional Cerebral Blood Flow, and Reduces Infarction Volume in the Rat , 1994, Stroke.

[256]  W. Armstead,et al.  Influence of endothelin on piglet cerebral microcirculation. , 1989, The American journal of physiology.

[257]  C. Garland,et al.  Endothelium‐dependent relaxation to acetylcholine in the rabbit basilar artery: importance of membrane hyperpolarization , 1992, British journal of pharmacology.

[258]  M. Yokoyama,et al.  Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines. , 1993, Journal of Biological Chemistry.

[259]  T. Kitazono,et al.  Enhanced responses of the basilar artery to activation of endothelin-B receptors in stroke-prone spontaneously hypertensive rats. , 1995, Hypertension.

[260]  N. Toda,et al.  Involvement of nitric oxide in endothelium-dependent, phasic relaxation caused by histamine in monkey cerebral arteries. , 1992, Japanese journal of pharmacology.

[261]  D. Reis,et al.  Cloning and expression of inducible nitric oxide synthase from rat astrocytes , 1994, Journal of neuroscience research.

[262]  W. Rosenblum Hydroxyl Radical Mediates the Endothelium‐Dependent Relaxation Produced by Bradykinin in Mouse Cerebral Arterioles , 1987, Circulation research.

[263]  D. Harrison,et al.  Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[264]  P. Ricciardi-Castagnoli,et al.  Inducible nitric oxide synthase activity of cloned murine microglial cells , 1993, Glia.

[265]  H. Esumi,et al.  Inducible Nitric Oxide Synthase in a Human Glioblastoma Cell Line , 1995, Journal of neurochemistry.

[266]  S. Snyder,et al.  Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[267]  C. Iadecola,et al.  Nitric Oxide Donors Increase Blood Flow and Reduce Brain Damage in Focal Ischemia: Evidence That Nitric Oxide is Beneficial in the Early Stages of Cerebral Ischemia , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[268]  K. Pritchard,et al.  Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure. , 1996, Circulation research.

[269]  T. Oury,et al.  Extracellular superoxide dismutase in vessels and airways of humans and baboons. , 1996, Free radical biology & medicine.

[270]  R. Traystman,et al.  Effect of postischemic hypoperfusion on vasodilatory mechanisms in cats. , 1994, The American journal of physiology.

[271]  L. Cathala,et al.  Neurotensin Inhibition of the Hyperpolarization‐Activated Cation Current (Ih) in the Rat Substantia Nigra Pars Compacta Implicates the Protein Kinase C Pathway , 1997, The Journal of physiology.

[272]  C. Sobey,et al.  Effect of nitric oxide and potassium channel agonists and inhibitors on basilar artery diameter. , 1997, The American journal of physiology.

[273]  C. Caldarera,et al.  Induction of Nitric Oxide Synthase mRNA Expression , 1995, The Journal of Biological Chemistry.

[274]  R. Catalán,et al.  Identification of nitric oxide synthases in isolated bovine brain vessels , 1996, Neuroscience Research.

[275]  K. Moritake,et al.  EFFECTS OF NITRO‐l‐ARGININE ON ENDOTHELIUM‐DEPENDENT RELAXATION OF CANINE CEREBRAL ARTERIES , 1993, Clinical and experimental pharmacology & physiology.

[276]  D. Heistad,et al.  Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. , 1995, The American journal of physiology.

[277]  D. Dewitt,et al.  Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. , 1985, Circulation research.

[278]  R. Cohen,et al.  Free radicals mediate endothelial cell dysfunction caused by elevated glucose. , 1992, The American journal of physiology.

[279]  M. Takayasu,et al.  An in vitro comparative study of conducting vessels and penetrating arterioles after experimental subarachnoid hemorrhage in the rabbit. , 1992, Journal of neurosurgery.

[280]  W. Armstead,et al.  Postischemic generation of superoxide anion by newborn pig brain. , 1988, The American journal of physiology.

[281]  H. Mehdorn,et al.  Effects of potassium channel openers in isolated human cerebral arteries. , 1995, Neurosurgery.

[282]  W. Armstead,et al.  Role of nitric oxide and cAMP in beta-adrenoceptor-induced pial artery vasodilation. , 1995, The American journal of physiology.

[283]  W. Meng,et al.  Ischemia reduces CGRP-induced cerebral vascular dilation in piglets. , 1996, Stroke.

[284]  D. Heistad,et al.  Mechanisms of endotoxin-induced dilatation of cerebral arterioles. , 1995, The American journal of physiology.

[285]  M. Pourcyrous,et al.  Brain Superoxide Anion Generation during Asphyxia and Reventilation in Newborn Pigs , 1990, Pediatric Research.

[286]  E. Ohlstein,et al.  Oxyhemoglobin stimulation of endothelin production in cultured endothelial cells. , 1992, Journal of neurosurgery.

[287]  F. Faraci Role of nitric oxide in regulation of basilar artery tone in vivo. , 1990, The American journal of physiology.

[288]  M. Fujishima,et al.  The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. , 1996, Journal of cardiovascular pharmacology.

[289]  R. Macdonald,et al.  Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. , 1996, Neurosurgery.

[290]  S. Lorenzl,et al.  Effect of the bradykinin B2 receptor antagonist Hoe140 in experimental pneumococcal meningitis in the rat. , 1996, European journal of pharmacology.

[291]  D. Heistad,et al.  Endothelium‐Derived Relaxing Factor Modulates Noradrenergic Constriction of Cerebral Arterioles in Rabbits , 1992, Stroke.

[292]  S. Ibayashi,et al.  Distribution and physiological roles of ATP-sensitive K+ channels in the vertebrobasilar system of the rabbit. , 1996, Circulation research.

[293]  X. Chen,et al.  RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease , 1996, Nature.

[294]  J. Pickard,et al.  Endothelin ETA receptor expression in human cerebrovascular smooth muscle cells , 1995, British journal of pharmacology.

[295]  C. Garland Influence of the endothelium and alpha‐adrenoreceptor antagonists on responses to noradrenaline in the rabbit basilar artery. , 1989, The Journal of physiology.

[296]  W. Armstead,et al.  Influence of Polyethylene Glycol Superoxide Dismutase/Catalase on Altered Opioid‐induced Pial Artery Dilation after Brain Injury , 1996, Anesthesiology.

[297]  Yasuyoshi Watanabe,et al.  Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever , 1996, Brain Research.

[298]  T. Sundt,et al.  Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage. , 1992, Circulation research.

[299]  M. Sugawa,et al.  BY-1949 elicits vasodilation via preferential elevation of cyclic GMP levels within the cerebral artery: possible involvement of endothelium-mediated mechanisms. , 1992, European journal of pharmacology.

[300]  H. Temme,et al.  Endothelial Cells in Culture , 1983 .

[301]  P. López-Jaramillo,et al.  The L-arginine: nitric oxide pathway. , 1993, Current opinion in nephrology and hypertension.

[302]  A. van Dam,et al.  Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin , 1995, Journal of neuroscience research.

[303]  C. Sobey,et al.  POTASSIUM CHANNELS AND THE CEREBRAL CIRCULATION , 1996, Clinical and experimental pharmacology & physiology.

[304]  D. Heistad,et al.  Impaired Relaxation of the Carotid Artery During Activation of ATP‐Sensitive Potassium Channels in Atherosclerotic Monkeys , 1994, Stroke.

[305]  R. Johns,et al.  Regulation of nitric oxide synthase by nitric oxide. , 1993, Molecular pharmacology.

[306]  J. Giudicelli,et al.  Effects of losartan on cerebral arteries in stroke-prone spontaneously hypertensive rats , 1996, Journal of hypertension.

[307]  M. Buchmeier,et al.  Expression of Inflammatory Cytokines and Inducible Nitric Oxide Synthase in Brains of SIV-Infected Rhesus Monkeys: Applications to HIV-Induced Central Nervous System Disease , 1996, Molecular medicine.

[308]  J. Y. Lee,et al.  Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles. , 1996, The American journal of physiology.

[309]  T. Kitazono,et al.  Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca(2+)-dependent K+ channels. , 1995, Circulation research.

[310]  F. Murad,et al.  Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. , 1993, The American journal of physiology.

[311]  A. Sher,et al.  Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[312]  R M Nerem,et al.  Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. , 1995, The American journal of physiology.

[313]  Richard G. W. Anderson,et al.  Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae (*) , 1996, The Journal of Biological Chemistry.

[314]  M. Fujishima,et al.  Cromakalim dilates rat cerebral arteries in vitro. , 1991, Stroke.

[315]  W. Mayhan,et al.  Glutamate-induced disruption of the blood-brain barrier in rats. Role of nitric oxide. , 1996, Stroke.

[316]  M. Mcdaniel,et al.  Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase , 1996, Journal of Neuroimmunology.

[317]  E. Canet,et al.  Inhibitors of the cytochrome P450‐mono‐oxygenase and endothelium‐dependent hyperpolarizations in the guinea‐pig isolated carotid artery , 1996, British journal of pharmacology.

[318]  S. O'Rourke,et al.  Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. , 1992, The American journal of physiology.

[319]  G. Nisticó,et al.  Cytokine-induced nitric oxide generation by cultured astrocytoma cells involves Ca(++)-calmodulin-independent NO-synthase. , 1993, Biochemical and biophysical research communications.

[320]  D. Benos,et al.  Polarization-dependent apical membrane CFTR targeting underlies cAMP-stimulated Cl- secretion in epithelial cells. , 1994, The American journal of physiology.

[321]  W. Armstead,et al.  Opioids contribute to hypoxia-induced pial artery dilation through activation of ATP-sensitive K+ channels. , 1995, The American journal of physiology.

[322]  Y. Yamaguchi,et al.  Cigarette smoke-modified low density lipoprotein impairs endothelium-dependent relaxation in isolated rabbit arteries. , 1996, General pharmacology.

[323]  R. Macallister,et al.  Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis , 1994, British journal of pharmacology.

[324]  C. Leffler,et al.  Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance. , 1990, Circulation research.

[325]  A. A. Taylor,et al.  Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries. , 1993, The Journal of clinical investigation.

[326]  T. Itoh,et al.  Factors inducing endothelium‐dependent relaxation in the guinea‐pig basilar artery as estimated from the actions of haemoglobin , 1989, British journal of pharmacology.

[327]  Z. Katušić,et al.  Superoxide anion is an endothelium-derived contracting factor. , 1989, The American journal of physiology.

[328]  M. Zuccarello,et al.  Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. , 1994, European journal of pharmacology.

[329]  M. Creager,et al.  Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. , 1997, Circulation.

[330]  E. Nagata,et al.  Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat , 1991, Neuroscience Letters.

[331]  K. Aldape,et al.  Expression of nitric oxide synthase in human central nervous system tumors. , 1995, Cancer research.

[332]  D. Heistad,et al.  Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles. , 1997, Stroke.

[333]  R Busse,et al.  Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. , 1996, Circulation.

[334]  L. Edvinsson,et al.  Characterization of endothelin‐A receptors in the cerebral circulation , 1993, Neuroreport.

[335]  S. Moncada,et al.  Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure , 1992, The Lancet.

[336]  T. Kitazono,et al.  Effect of norepinephrine on rat basilar artery in vivo. , 1993, The American journal of physiology.

[337]  J. Mcculloch,et al.  Calcitonin gene-related peptide: functional role in cerebrovascular regulation. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[338]  Z. Katušić,et al.  Similar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxide. , 1989, The American journal of physiology.

[339]  E. Hogan,et al.  Receptor‐Linked Hydrolysis of Phosphoinositides and Production of Prostacyclin in Cerebral Endothelial Cells , 1992, Journal of neurochemistry.

[340]  F. Rossi,et al.  Synergistic Induction of Nitric Oxide by β-Amyloid and Cytokines in Astrocytes , 1996 .

[341]  Ian G. Charles,et al.  Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[342]  Yasuyoshi Watanabe,et al.  Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response , 1995, Brain Research.

[343]  S. Kostyk,et al.  Basic fibroblast growth factor increases nitric oxide synthase production in bovine endothelial cells. , 1995, The American journal of physiology.

[344]  A. A. Parsons,et al.  Analysis of Acetylcholine-Induced Relaxation of Rabbit Isolated Middle Cerebral Artery: Effects of Inhibitors of Nitric Oxide Synthesis, Na,K-ATPase, and ATP-Sensitive K Channels , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[345]  O. Sagher,et al.  Cerebral microvascular responses to endothelins: the role of ETA receptors , 1994, Brain Research.

[346]  J. Vane,et al.  Up-to-date on endothelins , 1995 .

[347]  K. Sugita,et al.  Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog. , 1993, The Journal of pharmacology and experimental therapeutics.

[348]  R. Busse,et al.  Inhalation Anesthetics Inhibit the Release of Endothelium-derived Hyperpolarizing Factor in the Rabbit Carotid Artery , 1995, Anesthesiology.

[349]  D. Heistad,et al.  Effects of Local Reduction in Pressure on Endothelium‐Dependent Responses of Cerebral Arterioles , 1994, Stroke.

[350]  Z. Katušić,et al.  Anoxic Contractions in Isolated Canine Cerebral Arteries: Contribution of Endothelium‐Derived Factors, Metabolites of Arachidonic Acid, and Calcium Entry , 1986, Journal of cardiovascular pharmacology.

[351]  D. Reis,et al.  Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[352]  T. M. Griffith,et al.  The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries. , 1992, Journal of neurosurgery.

[353]  E. Canet,et al.  Endothelium‐derived factors and hyperpolarization of the carotid artery of the guinea‐pig , 1996, British journal of pharmacology.

[354]  P. Debré,et al.  Interleukin‐10 inhibits IgE‐mediated nitric oxide synthase induction and cytokine synthesis in normal human keratinocytes , 1995, European journal of immunology.

[355]  Y. Uezono,et al.  Pituitary adenylate cyclase-activating polypeptides (PACAPs) increase cAMP in rat cerebral microvessels , 1994, Brain Research.

[356]  Eric R Kandel,et al.  Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase , 1996, Cell.

[357]  K. Maiese,et al.  Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia , 1994, Brain Research.

[358]  R. Macdonald,et al.  Cerebral vasospasm and free radicals. , 1994, Free radical biology & medicine.

[359]  H. Shirahase,et al.  An endothelium-dependent contraction induced by A-23187, a Ca++ ionophore in canine basilar artery. , 1988, The Journal of pharmacology and experimental therapeutics.

[360]  A. M. Lefer,et al.  Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. , 1997, The Journal of clinical investigation.

[361]  W. Ward,et al.  Uptake and intracellular fate of [14C]sucrose-insulin in perfused rat livers. , 1988, The American journal of physiology.

[362]  M. Yanagisawa,et al.  ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 , 1994, Cell.

[363]  P. Tsao,et al.  Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. , 1992, The Journal of clinical investigation.

[364]  The Human Brain Circulation , 1994, Vascular Biomedicine.

[365]  John A. Williams,et al.  Lipopolysaccharide and interleukin 1 augment the effects of hypoxia and inflammation in human pulmonary arterial tissue. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[366]  A. Rudolph,et al.  Role of nitric oxide in the regulation of the cerebral circulation in the lamb fetus during normoxemia and hypoxemia. , 1995, Biology of the neonate.

[367]  S. Ueno,et al.  Distribution of Free Methylarginines in Rat Tissues and in the Bovine Brain , 1992, Journal of neurochemistry.

[368]  U. Ikeda,et al.  Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. , 1995, European journal of pharmacology.

[369]  A. Quyyumi,et al.  Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis. , 1995, The Journal of clinical investigation.

[370]  T. Mayadas,et al.  Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. , 1996, The Journal of clinical investigation.

[371]  J. Bockaert,et al.  Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons. , 1994, The Journal of biological chemistry.

[372]  H. Kontos,et al.  Independent blockade of cerebral vasodilation from acetylcholine and nitric oxide. , 1988, The American journal of physiology.

[373]  B. Tesfamariam Free radicals in diabetic endothelial cell dysfunction. , 1994, Free radical biology & medicine.

[374]  N. Akgören,et al.  Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression. , 1995, The American journal of physiology.

[375]  K. Takakura,et al.  Cerebral microvessel endothelium is producing endothelin , 1990, Brain Research.

[376]  R. Albrecht,et al.  Role of nitric oxide, adenosine,N-methyl-d-aspartate receptors, and neuronal activation in hypoxia-induced pial arteriolar dilation in rats , 1995, Brain Research.

[377]  D. Ganten,et al.  Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats. , 1996, The Journal of clinical investigation.

[378]  S. Moncada,et al.  Understanding the controversy over the identity of EDRF , 1994, Nature.

[379]  D. Heistad,et al.  Effects of arginine vasopressin on cerebral microvascular pressure. , 1988, The American journal of physiology.

[380]  K. Sugita,et al.  Regional differences in cerebral vasomotor control by nitric oxide , 1995, Brain Research Bulletin.

[381]  S. Nakanishi,et al.  Cloning and expression of a cDNA encoding an endothelin receptor , 1990, Nature.

[382]  S. Marklund,et al.  Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[383]  W. Armstead,et al.  Different Pial Arteriolar Responses to Acetylcholine in the Newborn and Juvenile Pig , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[384]  P. Vigne,et al.  Contributions of NO synthase and heme oxygenase to cGMP formation by cytokine and hemin treated brain capillary endothelial cells. , 1995, Biochemical and biophysical research communications.

[385]  J. Brayden Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation. , 1990, The American journal of physiology.

[386]  H. Usui,et al.  Endothelium-dependent contraction inhibitor (LP-805) in canine basilar and mesenteric artery , 1992 .

[387]  E. Ellis,et al.  Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin. , 1995, The American journal of physiology.

[388]  T. Sundt,et al.  Alterations in endothelium-dependent responsiveness of the canine basilar artery subarachnoid hemorrhage. , 1988, Journal of neurosurgery.

[389]  F. Cosentino,et al.  Role of superoxide anions in the mediation of endothelium-dependent contractions. , 1994, Hypertension.

[390]  D. Harrison,et al.  Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. , 1987, The Journal of clinical investigation.

[391]  H. Arita,et al.  Effect of pancreatic type phospholipase A2 on isolated porcine cerebral arteries via its specific binding sites , 1992, FEBS letters.

[392]  Tomio Sasaki,et al.  Localization and Alteration of Immunoreactive Endothelin-1 in Canine Basilar Arteries Following Subarachnoid Hemorrhage , 1995 .

[393]  Y. Yamaguchi,et al.  DIFFERENCES IN ENDOTHELIUM‐DEPENDENT RELAXATION IN VARIOUS ARTERIES FROM WATANABE HERITABLE HYPERLIPIDAEMIC RABBITS WITH INCREASING AGE , 1994, Clinical and experimental pharmacology & physiology.

[394]  H. Shirahase,et al.  Endothelium-dependent contraction induced by nicotine in isolated canine basilar artery--possible involvement of a thromboxane A2 (TXA2) like substance. , 1988, Life sciences.

[395]  M. Moskowitz,et al.  Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression. , 1996, The American journal of physiology.

[396]  H. Shimizu,et al.  Effect of calcitonin gene-related peptide on delayed cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. , 1996, Surgical neurology.

[397]  J. Mitchell,et al.  Cyclooxygenase-2: regulation and relevance in inflammation. , 1995, Biochemical pharmacology.

[398]  P. Taylor,et al.  Glaxo/MRS Young Investigator Prize. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. , 1995, Clinical science.

[399]  H. Shirahase,et al.  Endothelium‐Dependent Contraction Produced by Acetylcholine and Relaxation Produced by Histamine in Monkey Basilar Arteries , 1992, Life sciences.

[400]  Z Benyó,et al.  Effects of NG‐nitro‐L‐arginine and L‐arginine on regional cerebral blood flow in the cat. , 1992, The Journal of physiology.

[401]  C. Chiang,et al.  Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. , 1994, Journal of immunology.

[402]  K. Sugita,et al.  Mechanism of the Enhanced Vasoconstrictor Responses to Endothelin-1 in Canine Cerebral Arteries , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[403]  R. Janzer,et al.  Tumor cells suppress cytokine‐induced nitric‐oxide (no) production in cerebral endothelial cells , 1994, International journal of cancer.

[404]  D. Heistad,et al.  Effects of atherosclerosis on cerebral vessels: hemodynamic and morphometric studies. , 1986, Stroke.

[405]  B. Mayer,et al.  Immunohistochemical localization of nitric oxide synthase in rat anterior choroidal artery, stromal blood microvessels, and choroid plexus epithelial cells , 1996, Cell and Tissue Research.

[406]  R. Cohen,et al.  Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. , 1995, Circulation.

[407]  S Moncada,et al.  Nitric oxide synthases in mammals. , 1994, The Biochemical journal.

[408]  D. Heistad,et al.  Dilatation of cerebral arterioles in response to lipopolysaccharide in vivo. , 1995, Stroke.

[409]  J. Lombard,et al.  Role of endothelium and arterial K+ channels in mediating hypoxic dilation of middle cerebral arteries. , 1994, The American journal of physiology.

[410]  L. Edvinsson,et al.  Presence of contractile endothelin-A and dilatory endothelin-B receptors in human cerebral arteries. , 1997, Neurosurgery.

[411]  D. Harrison,et al.  Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[412]  R. Busse,et al.  Endothelial dysfunction in atherosclerosis. , 1996, Journal of vascular research.

[413]  M. Moskowitz,et al.  The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[414]  P. Zygmunt,et al.  Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein , 1996, British journal of pharmacology.

[415]  S. Lorenzl,et al.  Antioxidants Attenuate Microvascular Changes in the Early Phase of Experimental Pneumococcal Meningitis in Rats , 1992, Stroke.

[416]  D. W. Cheung,et al.  Characterization of acetylcholine-induced membrane hyperpolarization in endothelial cells. , 1992, Circulation research.

[417]  Yuan‐jian Li,et al.  Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits. , 1994, Life sciences.

[418]  E. Ellis,et al.  Role of prostaglandins in pial arteriolar response to CO2 and hypoxia. , 1980, The American journal of physiology.

[419]  M. Moskowitz,et al.  The Trigeminal Nerve and Augmentation of Regional Cerebral Blood Flow during Experimental Bacterial Meningitis , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[420]  M. Hart,et al.  Involvement of nitric oxide in IFN-γ-mediated reduction of microvessel smooth muscle cell proliferation , 1995 .

[421]  W. Mayhan,et al.  L-Arginine Does Not Restore Dilatation of the Basilar Artery during Diabetes Mellitus , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[422]  L. Rorke,et al.  In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[423]  K. Uemura,et al.  Interrelation between protein kinase C and nitric oxide in the development of vasospasm after subarachnoid hemorrhage. , 1996, Neurological research.

[424]  R. Albrecht,et al.  Role of nitric oxide and endothelium in rat pial vessel dilation response to isoflurane. , 1994, Anesthesia and analgesia.

[425]  A. A. Parsons,et al.  Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat. , 1995, Journal of neurosurgery.

[426]  H. S. Kim,et al.  Elevated blood pressures in mice lacking endothelial nitric oxide synthase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[427]  K. Wu,et al.  Role of endothelium in thrombosis and hemostasis. , 1996, Annual review of medicine.

[428]  H. Drexler,et al.  Reduced plasma L-arginine in hypercholesterolaemia , 1992, The Lancet.

[429]  J. Mcculloch,et al.  Endothelin receptor mediated constriction and dilatation in feline cerebral resistance arterioles in vivo. , 1996, European journal of pharmacology.

[430]  C. Szabó,et al.  Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. , 1996, Biochemical pharmacology.

[431]  G. Yang,et al.  Glutamate microinjections in cerebellar cortex reproduce cerebrovascular effects of parallel fiber stimulation. , 1996, The American journal of physiology.

[432]  S. Marklund,et al.  The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[433]  C. Nathan,et al.  Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase , 1995, Cell.

[434]  D. Heistad,et al.  Dietary Treatment of Atherosclerosis Abolishes Hyperresponsiveness of Retinal Blood Vessels to Serotonin in Monkeys , 1991, Stroke.

[435]  S. Tokudome,et al.  Altered reactivity of human cerebral arteries after subarachnoid hemorrhage. , 1995, Journal of neurosurgery.

[436]  Y. Hattori,et al.  Up-regulation of rat adrenomedullin gene expression by endotoxin: relation to nitric oxide synthesis. , 1996, Life sciences.

[437]  D. Heistad,et al.  Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats. , 1991, Stroke.

[438]  C. Saper,et al.  Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide , 1996, Brain Research.

[439]  M. Nelson,et al.  ATP-sensitive K+ currents in cerebral arterial smooth muscle: pharmacological and hormonal modulation. , 1995, The American journal of physiology.

[440]  M. Mulvany,et al.  Functional properties in vitro of systemic small arteries from rabbits fed a cholesterol-rich diet for 12 weeks. , 1991, Clinical science.

[441]  T. Saruta,et al.  Up‐regulation of nitric oxide synthase by estradiol in human aorticendothelial cells , 1995, FEBS letters.

[442]  T. Kitazono,et al.  ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. , 1994, Circulation research.

[443]  A. Keech,et al.  Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. , 1996, The Journal of clinical investigation.

[444]  T. Ohhashi,et al.  Prostaglandin F2 alpha-induced endothelium-dependent relaxation in isolated monkey cerebral arteries. , 1991, The American journal of physiology.

[445]  H. Ellis stroke , 1997, The Lancet.

[446]  T. Masaki,et al.  Calcitonin gene-related peptide and vasodilator nerves in large cerebral arteries of cats. , 1989, The Journal of pharmacology and experimental therapeutics.

[447]  M. Moskowitz,et al.  Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. , 1994, Science.

[448]  H. Koprowski,et al.  Local nitric oxide production in viral and autoimmune diseases of the central nervous system. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[449]  D. Harrison,et al.  Hypercholesterolemia increases endothelial superoxide anion production. , 1993, The Journal of clinical investigation.

[450]  R. Traystman,et al.  N omega-nitro-L-arginine methyl ester prevents cerebral hyperemia by inhaled anesthetics in dogs. , 1993, Anesthesia and analgesia.

[451]  M. Ross,et al.  Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. , 1996, Stroke.

[452]  L. Edvinsson,et al.  Characterization of Calcitonin Gene—Related Peptide Receptors in Human Cerebral Vessels , 1992 .

[453]  M. Polokoff,et al.  Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. , 1994, Pharmacological reviews.

[454]  C. Sobey,et al.  Potassium channels mediate dilatation of cerebral arterioles in response to arachidonate. , 1998, American journal of physiology. Heart and circulatory physiology.

[455]  R. Furchgott,et al.  Blockade of nitric oxide-induced relaxation of rabbit aorta by cysteine and homocysteine. , 1997, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[456]  W. Mayhan Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels , 1994, Brain Research.

[457]  Terry D. Lee,et al.  Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. , 1992, Science.

[458]  T. Gupta,et al.  Role of Nitric Oxide , 1998, Digestion.

[459]  Y. Hirata,et al.  Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. , 1993, The Journal of clinical investigation.

[460]  Y. Hattori,et al.  Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. , 1991, The American journal of physiology.

[461]  W. Kuschinsky,et al.  Perivascular Potassium and pH as Determinants of Local Pial Arterial Diameter in Cats: A MICROAPPLICATION STUDY , 1972, Circulation research.

[462]  P. Ganz,et al.  Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. , 1986, The New England journal of medicine.

[463]  G. D. del Zoppo,et al.  P‐Selectin and Intercellular Adhesion Molecule‐1 Expression After Focal Brain Ischemia and Reperfusion , 1994, Stroke.

[464]  M. Yoshizumi,et al.  Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. , 1993, Circulation research.

[465]  D. Heistad,et al.  Flow-mediated dilatation of the basilar artery in vivo. , 1991, Circulation research.

[466]  K. Sugita,et al.  Effects of Adrenomedullin, Calcitonin Gene-Related Peptide, and Amylin on Cerebral Circulation in Dogs , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[467]  J. Saavedra,et al.  Angiotensin IV Reverses the Acute Cerebral Blood Flow Reduction after Experimental Subarachnoid Hemorrhage in the Rat , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[468]  G. H. Nelson,et al.  Endothelium‐Dependent Effects of Substance P and Calcitonin Gene‐Related Peptide on Mouse Pial Arterioles , 1993, Stroke.

[469]  William L. Smith,et al.  Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2* , 1996, The Journal of Biological Chemistry.

[470]  H. Kontos,et al.  H2O2 and endothelium-dependent cerebral arteriolar dilation. Implications for the identity of endothelium-derived relaxing factor generated by acetylcholine. , 1990, Hypertension.

[471]  B. Thompson,et al.  Effect of intracarotid nitric oxide on primate cerebral vasospasm after subarachnoid hemorrhage. , 1995, Journal of neurosurgery.

[472]  M. Nakane,et al.  Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage. , 1995, Journal of neurosurgery.

[473]  P. Kubes,et al.  Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[474]  K. Breese,et al.  Nitric oxide contributes to dilatation of cerebral arterioles during seizures. , 1993, The American journal of physiology.

[475]  C. Yokoyama,et al.  Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells , 1995, The Journal of Biological Chemistry.

[476]  C. Sobey,et al.  Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. , 1996, The Journal of clinical investigation.

[477]  G. Pieper,et al.  Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. , 1992, The American journal of physiology.

[478]  A. McCall,et al.  Reperfusion decreases myogenic reactivity and alters middle cerebral artery function after focal cerebral ischemia in rats. , 1997, Stroke.

[479]  F. Marumo,et al.  Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells. , 1993, HYPERTENSION.

[480]  D. Harrison,et al.  Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. , 1991, Circulation research.

[481]  V. Schini-Kerth,et al.  Nitric oxide synthases in vascular cells , 1995, Experimental physiology.

[482]  R. Willette,et al.  Nonpeptide Endothelin Antagonist: Cerebrovascular Characterization and Effects on Delayed Cerebral Vasospasm , 1994, Stroke.

[483]  E. Hoffman,et al.  Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene. , 1994, The Journal of biological chemistry.

[484]  R. Traystman,et al.  Cerebral blood flow during inhibition of brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats. , 1995, Stroke.

[485]  J. Keaney,et al.  Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. , 1995, Progress in cardiovascular diseases.

[486]  O. McManus,et al.  Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle. , 1995, Biochemistry.

[487]  T. Kitazono,et al.  L-arginine restores dilator responses of the basilar artery to acetylcholine during chronic hypertension. , 1996, Hypertension.

[488]  N. Toda,et al.  Endothelium-dependent and independent responses to prostaglandin H2 and arachidonic acid in isolated dog cerebral arteries. , 1988, The Journal of pharmacology and experimental therapeutics.

[489]  T. Shigeno,et al.  The effect of bosentan, a new potent endothelin receptor antagonist, on the pathogenesis of cerebral vasospasm. , 1995 .

[490]  W. Mayhan Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus. , 1989, The American journal of physiology.

[491]  W. Meng,et al.  Global ischemia impairs ATP-sensitive K+ channel function in cerebral arterioles in piglets. , 1996, Stroke.

[492]  E. Bouskela,et al.  Inhibition of Nitric Oxide Synthase Attenuates the Cerebral Blood Flow Response to Stimulation of Postganglionic Parasympathetic Nerves in the Rat , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[493]  M. Moskowitz,et al.  Trigeminalectomy modifies pial arteriolar responses to hypertension or norepinephrine. , 1988, The American journal of physiology.

[494]  H. Ehrenreich,et al.  Endothelin-3-Induced Relaxation of Isolated Rat Basilar Artery is Mediated by an Endothelial ETB-Type Endothelin Receptor , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[495]  M. Bukrinsky,et al.  Cytokine‐stimulated astrocytes damage human neurons via a nitric oxide mechanism , 1996, Glia.

[496]  D. Harrison,et al.  Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. , 1995, Circulation.

[497]  M. Moskowitz,et al.  Postocclusive cerebral hyperemia is markedly attenuated by chronic trigeminal ganglionectomy. , 1989, The American journal of physiology.

[498]  C. Lau,et al.  Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients , 1993, The Lancet.

[499]  R. Busse,et al.  Display of the characteristics of endothelium‐derived hyperpolarizing factor by a cytochrome P450‐derived arachidonic acid metabolite in the coronary microcirculation , 1994, British journal of pharmacology.

[500]  J. Falck,et al.  Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. , 1992, The American journal of physiology.

[501]  W. Hop,et al.  The role of nitric oxide in bacterial meningitis in children. , 1996, The Journal of infectious diseases.

[502]  S. Milstien,et al.  Cerebrospinal Fluid Nitrite/Nitrate Levels in Neurologic Diseases , 1994, Journal of neurochemistry.

[503]  R. Sercombe,et al.  Cerebrovascular reactivity: role of endothelium/platelet/leukocyte interactions. , 1996, Cerebrovascular and brain metabolism reviews.

[504]  J. Falck,et al.  Brain Synthesis and Cerebrovascular Action of Epoxygenase Metabolites of Arachidonic Acid , 1992, Journal of neurochemistry.

[505]  Amos Etzioni,et al.  Adhesion Molecules-Their Role in Health and Disease , 1996, Pediatric Research.

[506]  Simon C Watkins,et al.  Vascular Gene Transfer of the Human Inducible Nitric Oxide Synthase: Characterization of Activity and Effects on Myointimal Hyperplasia , 1996, Molecular medicine.

[507]  X. Xu,et al.  SIN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors. , 1994, The American journal of physiology.

[508]  P. Belloni,et al.  Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. , 1990, Journal of the National Cancer Institute.

[509]  H. Kontos,et al.  Endothelium-dependent responses after experimental brain injury. , 1992, Journal of neurotrauma.

[510]  M. Yanagisawa,et al.  Endothelins: vasoconstrictor effects and localization in canine cerebral arteries , 1991, British journal of pharmacology.

[511]  W. Armstead Role of Nitric Oxide, Cyclic Nucleotides, and the Activation of ATP-Sensitive K+ Channels in the Contribution of Adenosine to Hypoxia-Induced Pial Artery Dilation , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[512]  C. Thiemermann Biosynthesis and interaction of endothelium-derived vasoactive mediators. , 1991, Eicosanoids.

[513]  C. Iadecola,et al.  Nitroprusside improves blood flow and reduces brain damage after focal ischemia. , 1993, Neuroreport.

[514]  Z. Fu,et al.  Intrinsic responses to Borna disease virus infection of the central nervous system. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[515]  A. Asai,et al.  Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a canine subarachnoid hemorrhage model. , 1994, Journal of neurosurgery.

[516]  L. Edvinsson,et al.  Endothelin-A receptors mediate contraction in human cerebral, meningeal and temporal arteries. , 1994, Journal of the autonomic nervous system.

[517]  R. Traystman,et al.  Nitric oxide synthase inhibition with NG-mono‐methyl-L‐arginine reversibly decreases cerebral blood flow in piglets , 1994, Critical care medicine.

[518]  J. Povlishock,et al.  Effects of oxygen radicals on cerebral arterioles. , 1985, The American journal of physiology.

[519]  M. Moskowitz,et al.  Hypertension in mice lacking the gene for endothelial nitric oxide synthase , 1995, Nature.

[520]  R. Busse,et al.  Regulation and functional consequences of endothelial nitric oxide formation. , 1995, Annals of medicine.

[521]  M. Yacoub,et al.  Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[522]  N. Simonian,et al.  Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage. , 1996, Stroke.

[523]  J. Loscalzo,et al.  Nitric oxide and its role in the cardiovascular system. , 1995, Progress in cardiovascular diseases.

[524]  H. Kinoshita,et al.  Role of potassium channels in relaxations of isolated canine basilar arteries to acidosis. , 1997, Stroke.

[525]  Jonathan D. Cohen,et al.  The Cytokine Responsive Vascular Smooth Muscle Cell Enhancer of Inducible Nitric Oxide Synthase , 1995, The Journal of Biological Chemistry.

[526]  J. T. Shepherd,et al.  Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid, and acetylcholine in canine basilar arteries. , 1988, Stroke.

[527]  J. B. Salom,et al.  Endothelin receptors mediating contraction in goat cerebral arteries , 1993, British journal of pharmacology.

[528]  D. Reis,et al.  Nitric Oxide Synthase Expression in Glial Cells: Suppression by Tyrosine Kinase Inhibitors , 1994, Journal of neurochemistry.

[529]  M. Marcus,et al.  Effect of Sympathetic Stimulation on Permeability of the Blood‐Brain Barrier to Albumin during Acute Hypertension in Cats , 1979, Circulation research.

[530]  M. Zuccarello,et al.  Relaxation of subarachnoid hemorrhage-induced spasm of rabbit basilar artery by the K+ channel activator cromakalim. , 1996, Stroke.

[531]  C. Garland,et al.  Endothelium-dependent hyperpolarization: a role in the control of vascular tone. , 1995, Trends in pharmacological sciences.

[532]  J. Beckman The double-edged role of nitric oxide in brain function and superoxide-mediated injury. , 1991, Journal of developmental physiology.

[533]  S. Bode-Böger,et al.  The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications. , 1996, Atherosclerosis.

[534]  R. Koehler,et al.  In vivo production of nitric oxide correlates with NMDA-induced cerebral hyperemia in newborn sheep. , 1995, The American journal of physiology.

[535]  R. Dacey,et al.  N omega-nitro-L-arginine constricts cerebral arterioles without increasing intracellular calcium levels. , 1994, The American journal of physiology.

[536]  R. Haberl,et al.  Different mechanisms of l-arginine induced dilation of brain arterioles in normotensive and hypertensive rats , 1995, Brain Research.

[537]  I. Adcock,et al.  Differential regulation of the constitutive and inducible nitric oxide synthase mRNA by lipopolysaccharide treatment in vivo in the rat. , 1996, Critical care medicine.

[538]  Richard Graham Knowles,et al.  Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. , 1991, The Journal of biological chemistry.

[539]  G. Watts,et al.  Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia , 1992, The Lancet.

[540]  F. Ashcroft,et al.  Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes. , 1997, The Journal of physiology.

[541]  M. Nakamura,et al.  Putative mechanisms of the impairment of endothelium-dependent relaxation of the aorta with atheromatous plaque in heritable hyperlipidemic rabbits. , 1991, Circulation research.

[542]  W. S. Lee,et al.  Disturbances in autoregulatory responses of rat pial arteries by sulfonylureas. , 1993, Life sciences.

[543]  A. Allison,et al.  Inhibitory effect of di-catechol rooperol on VCAM-1 and iNOS expression in cytokine-stimulated endothelium. , 1996, Life sciences.

[544]  C. Leffler,et al.  Mechanisms of hypoxia-induced cerebrovascular dilation in the newborn pig. , 1997, The American journal of physiology.

[545]  T. Kitazono,et al.  Role of ATP-sensitive K+ channels in CGRP-induced dilatation of basilar artery in vivo. , 1993, The American journal of physiology.

[546]  K. Wu,et al.  Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. , 1995, Circulation research.

[547]  W. Armstead,et al.  The role of nitric oxide in opioid-induced pial artery vasodilation , 1995, Brain Research.

[548]  D. Heistad,et al.  Effects of endothelin on blood vessels of the brain and choroid plexus , 1990, Brain Research.

[549]  K. Breese,et al.  Cerebral Vasodilation During Hypercapnia: Role of Glibenclamide-Sensitive Potassium Channels and Nitric Oxide , 1994, Stroke.

[550]  R. Busto,et al.  Endothelin Levels Increase in Rat Focal and Global Ischemia , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[551]  H. Kontos Oxygen Radicals in Cerebral Vascular Injury , 1985 .

[552]  W. A. Bradley,et al.  Superoxide and peroxynitrite in atherosclerosis. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[553]  K. Hongo,et al.  Effect of subarachnoid hemorrhage on calcitonin gene-related peptide-induced relaxation in rabbit basilar artery. , 1989, Stroke.

[554]  F. Ashcroft,et al.  Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. , 1995, The American journal of physiology.

[555]  C. Estrada,et al.  Effects of TNF-α on the Production of Vasoactive Substances by Cerebral Endothelial and Smooth Muscle Cells in Culture , 1995 .

[556]  S H Snyder,et al.  Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[557]  L. Kobzik,et al.  Endothelial Nitric Oxide Synthase Targeting to Caveolae , 1996, The Journal of Biological Chemistry.

[558]  K. Frei,et al.  Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis. , 1996, Journal of immunology.

[559]  G. H. Nelson,et al.  Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels. , 1990, The American journal of physiology.

[560]  J. Marín Age-related changes in vascular responses: a review , 1995, Mechanisms of Ageing and Development.

[561]  C. D'amato,et al.  Characterization of contractile responses to endothelin in human cerebral arteries: implications for cerebral vasospasm. , 1990, Neurosurgery.

[562]  H. Hama,et al.  Molecular pharmacology and pathophysiological significance of endothelin. , 1996, Japanese journal of pharmacology.

[563]  S. Moncada,et al.  Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[564]  M. Maines Carbon Monoxide: An Emerging Regulator of cGMP in the Brain , 1993, Molecular and Cellular Neuroscience.

[565]  D. Webb,et al.  The endothelin system and its potential as a therapeutic target in cardiovascular disease. , 1996, Pharmacology & therapeutics.

[566]  P. Tempst,et al.  Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[567]  S. Papadopoulos,et al.  Endothelium dependency of contractile activity differs in infant and adult vertebral arteries. , 1994, The Journal of clinical investigation.

[568]  J. Liao,et al.  Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide. , 1996, Biochemical and biophysical research communications.

[569]  H. Shimokawa,et al.  Endothelium‐Dependent Relaxation to Aggregating Platelets in Isolated Basilar Arteries of Control and Hypercholesterolemic Pigs , 1988, Circulation research.

[570]  B. E. Robertson,et al.  cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. , 1993, The American journal of physiology.

[571]  K. Sugita,et al.  Combined effect of L-arginine and superoxide dismutase on the spastic basilar artery after subarachnoid hemorrhage in dogs. , 1994, Journal of neurosurgery.

[572]  M. Takayasu,et al.  Regional Differences in the Vasodilator Response to Vasopressin in Canine Cerebral Arteries In Vivo , 1993, Stroke.

[573]  C. Lowenstein,et al.  Arrest of endotoxin-induced hypotension by transforming growth factor beta1. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[574]  C. Sobey,et al.  Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. , 1997, Stroke.

[575]  Cerebrovascular effects of NG-nitro-L-arginine methylester are conserved under halothane anaesthesia. , 1993, European journal of pharmacology.

[576]  C. Iadecola,et al.  Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. , 1995, The American journal of physiology.

[577]  M. Yakubu,et al.  Subarachnoid Hematoma Attenuates Vasodilation and Potentiates Vasoconstriction Induced by Vasoactive Agents in Newborn Pigs , 1994, Pediatric Research.

[578]  R. Ekman,et al.  Involvement of Perivascular Sensory Fibers in the Pathophysiology of Cerebral Vasospasm following Subarachnoid Hemorrhage , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[579]  M. Yano,et al.  A novel endothelin ETA receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs. , 1993, Biochemical and biophysical research communications.

[580]  D. Heistad,et al.  Responses of Cerebral Arterioles to Adenosine 5'‐Diphosphate, Serotonin, and the Thromboxane Analogue U‐46619 During Chronic Hypertension , 1988, Hypertension.

[581]  H. Kobayashi,et al.  Cerebral vasospasm and vasoconstriction caused by endothelin. , 1991, Neurosurgery.

[582]  T. Billiar The delicate balance of nitric oxide and superoxide in liver pathology. , 1995, Gastroenterology.

[583]  D. Heistad,et al.  Effects of angiotensin II on blood flow to choroid plexus. , 1990, The American journal of physiology.

[584]  L. Edvinsson,et al.  Calcitonin Gene-Related Peptide is Released from Capsaicin-Sensitive Nerve Fibres and Induces Vasodilatation of Human Cerebral Arteries Concomitant with Activation of Adenylyl Cyclase , 1996, Cephalalgia : an international journal of headache.

[585]  B. Halliwell,et al.  Nitric oxide and oxygen radicals: a question of balance , 1995, FEBS letters.

[586]  L. Edvinsson,et al.  Responses of Isolated Feline and Human Cerebral Arteries to Prostacyclin and Some of its Metabolites , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[587]  Y. Fukuuchi,et al.  Dilatation of cerebral microvessels mediated by endothelin ETB receptor and nitric oxide in cats , 1994, Neuroscience Letters.

[588]  Carl Nathan,et al.  Nitric oxide synthases: Roles, tolls, and controls , 1994, Cell.

[589]  R. Ikegawa,et al.  Phosphoramidon prevents cerebral vasospasm following subarachnoid hemorrhage in dogs: the relationship to endothelin-1 levels in the cerebrospinal fluid. , 1991, Life sciences.

[590]  A. Nishida,et al.  Comparative evaluation of the role of endogenous gastrin in basal acid secretion in conscious rats provided with chronic fistula and pylorus ligation. , 1996, Japanese journal of pharmacology.

[591]  M. Takayasu,et al.  Differential effects of intra- and extraluminal endothelin on cerebral arterioles. , 1991, The American journal of physiology.

[592]  J. Brayden,et al.  Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP‐sensitive potassium channels. , 1995, The Journal of physiology.

[593]  D. Cook,et al.  Pharmacological studies on relaxation of spastic primate cerebral arteries in subarachnoid hemorrhage. , 1989, Journal of neurosurgery.

[594]  T. Yanagihara,et al.  Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia , 1996, Brain Research.

[595]  W. Armstead Role of activation of calcium-sensitive K+ channels and cAMP in opioid-induced pial artery dilation , 1997, Brain Research.

[596]  P. Goadsby,et al.  Characterization of Endothelin Receptors in the Cerebral Vasculature and Their Lack of Effect on Spreading Depression , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[597]  W. Mayhan Role of nitric oxide in histamine-induced increases in permeability of the blood–brain barrier , 1996, Brain Research.

[598]  G. Silverberg,et al.  The action potential and underlying ionic currents in proximal rat middle cerebral arterioles. , 1986, The Journal of physiology.

[599]  S. Moncada,et al.  The L-arginine-nitric oxide pathway. , 1993, The New England journal of medicine.

[600]  W. Mayhan Effect of diabetes mellitus on responses of the rat basilar artery to activation of beta-adrenergic receptors , 1994, Brain Research.

[601]  F. Faraci Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. , 1991, The American journal of physiology.

[602]  K. Kamata,et al.  Changes in superoxide dismutase mRNA expression by streptozotocin‐induced diabetes , 1996, British journal of pharmacology.

[603]  J. Pollock,et al.  Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. , 1994, Biochemical and biophysical research communications.

[604]  O. McManus,et al.  High-conductance calcium-activated potassium channels; Structure, pharmacology, and function , 1996, Journal of bioenergetics and biomembranes.

[605]  T. Yoshimoto,et al.  Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumors. , 1996, Biochemical and biophysical research communications.

[606]  M. Yano,et al.  The role of endothelin and nitric oxide in modulation of normal and spastic cerebral vascular tone in the dog. , 1995, European journal of pharmacology.

[607]  K. Sanders,et al.  Cloning and characterization of a Kv1.5 delayed rectifier K+ channel from vascular and visceral smooth muscles. , 1994, The American journal of physiology.

[608]  A. Bill,et al.  Effects of NG‐nitro‐l‐arginine methyl ester on the cardiovascular system of the anaesthetized rabbit and on the cardiovascular response to thyrotropin‐releasing hormone , 1993, British journal of pharmacology.

[609]  M. Ross,et al.  Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[610]  G. Mcpherson,et al.  The resistance of some rat cerebral arteries to the vasorelaxant effect of cromakalim and other K+ channel openers , 1992, British journal of pharmacology.

[611]  A. Villringer,et al.  Role of Nitric Oxide Synthase Inhibition in Leukocyte-Endothelium Interaction in the Rat Pial Microvasculature , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[612]  M. Gimbrone,et al.  Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[613]  Simon C Watkins,et al.  Inducible Nitric Oxide Synthase Expression in Cerebrovascular Smooth Muscle and Neutrophils after Traumatic Brain Injury in Immature Rats1 , 1996, Pediatric Research.

[614]  Frederic S. Fay,et al.  Calcium Sparks in Vascular Smooth Muscle—Relaxation Regulators , 1995, Science.

[615]  J. P. Schwartz,et al.  Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine , 1994, British journal of pharmacology.

[616]  H. Loiseau,et al.  Differential expression of inducible nitric oxide synthase mRNA in human brain tumours , 1995, Neuroreport.

[617]  D. Heistad,et al.  Gene therapy for cerebral vascular disease. , 1996, Stroke.

[618]  M. Nakane,et al.  Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. , 1994, Hypertension.

[619]  H. Winn,et al.  Physiological properties of ATP-activated cation channels in rat brain microvascular endothelial cells. , 1996, The American journal of physiology.

[620]  J. Saavedra,et al.  Characterization of endothelinA receptors in cerebral and peripheral arteries of the rat , 1995, Peptides.

[621]  J. Bereta,et al.  Stimulatory effect of ouabain on VCAM‐1 and iNOS expression in murine endothelial cells: involvement of NF‐κB , 1995, FEBS letters.

[622]  K. I. Maynard,et al.  L-NNA decreases cortical hyperemia and brain cGMP levels following CO2 inhalation in Sprague-Dawley rats. , 1994, The American journal of physiology.

[623]  K A Dora,et al.  A test of the role of flow-dependent dilation in arteriolar responses to occlusion. , 1997, The American journal of physiology.

[624]  M. Takiguchi,et al.  Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage‐like cell line , 1996, FEBS letters.

[625]  R. Koehler,et al.  Nitric oxide synthase 1 and nitric oxide synthase 3 protein expression is regionally and temporally regulated in fetal brain. , 1996, Brain research. Developmental brain research.

[626]  Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. , 1995 .

[627]  J. Povlishock,et al.  Oxygen Radicals Mediate the Cerebral Arteriolar Dilation from Arachidonate and Bradykinin in Cats , 1984, Circulation research.

[628]  M. Chopp,et al.  Cerebral Endothelial Nitric Oxide Synthase Expression After Focal Cerebral Ischemia in Rats , 1993, Stroke.

[629]  M. Condorelli,et al.  Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. , 1991, The New England journal of medicine.

[630]  R. Parker Absorption, metabolism, and transport of carotenoids , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[631]  J. Pollock,et al.  The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(*) , 1995, The Journal of Biological Chemistry.

[632]  J. Bereta,et al.  Stimulation of glyceraldehyde-3-phosphate dehydrogenase mRNA levels by endogenous nitric oxide in cytokine-activated endothelium. , 1995, Biochemical and biophysical research communications.

[633]  F. Edwards,et al.  Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation. , 1988, The Journal of physiology.

[634]  T. Lüscher,et al.  Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. , 1996, The Journal of clinical investigation.

[635]  J. J. Stone,et al.  Incidence of Maternal Postpartum Neurologic Dysfunction , 1994 .

[636]  Y. Notsu,et al.  An endothelin ETA receptor antagonist, FR139317, ameliorates cerebral vasospasm in dogs. , 1993, Life sciences.

[637]  M. Wahl,et al.  Bradykinin dilates rat middle cerebral artery and its large branches via endothelial B2 receptors and release of nitric oxide , 1996, Peptides.

[638]  N. Standen,et al.  Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle , 1996, British journal of pharmacology.

[639]  M. Goligorsky,et al.  Molecular and functional characterization of the non-isopeptide-selective ETB receptor in endothelial cells. Receptor coupling to nitric oxide synthase. , 1994, The Journal of biological chemistry.

[640]  J S Beckman,et al.  Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. , 1996, The American journal of physiology.

[641]  A. Quyyumi,et al.  Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. , 1990, The New England journal of medicine.

[642]  R. Macdonald,et al.  Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. , 1991, Cerebrovascular and brain metabolism reviews.

[643]  W. Jiménez,et al.  Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. , 1996, Hepatology.

[644]  J. Povlishock,et al.  Inhibition by arachidonate of cerebral arteriolar dilation from acetylcholine. , 1989, The American journal of physiology.

[645]  J. Povlishock,et al.  Appearance of Superoxide Anion Radical in Cerebral Extracellular Space during Increased Prostaglandin Synthesis in Cats , 1985, Circulation research.

[646]  A. Weston,et al.  Analysis of the depressant effect of the endothelium on contractions of rabbit isolated basilar artery to 5‐hydroxytryptamine , 1992, British journal of pharmacology.

[647]  M. Moskowitz,et al.  Basic Fibroblast Growth Factor Dilates Rat Pial Arterioles , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[648]  R. McCarron IL-1-induced prostacyclin production by cerebral vascular endothelial cells inhibits myelin basic protein-specific lymphocyte proliferation. , 1992, Cellular immunology.

[649]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[650]  L. Monge,et al.  Endothelin-1-induced in vitro cerebral venoconstriction is mediated by endothelin ETA receptors. , 1995, European journal of pharmacology.

[651]  M. Moskowitz,et al.  l‐Arginine dilates rat pial arterioles by nitric oxide‐dependent mechanisms and increases blood flow during focal cerebral ischaemia , 1992, British journal of pharmacology.

[652]  Nitric oxide modulates blood‐brain barrier permeability during infections with an inactivated bacterium , 1995, Neuroreport.

[653]  Weir,et al.  Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. , 1995, Journal of neurosurgery.

[654]  P. Cuatrecasas,et al.  In search of a second messenger for insulin. , 1988, The American journal of physiology.

[655]  S. Okuyama,et al.  Age-related changes in endothelium-dependent relaxation in aorta from genetically diabetic WBN/Kob rats. , 1992, The American journal of physiology.

[656]  Z. Katušić,et al.  Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery. , 1993, The American journal of physiology.

[657]  B. Fredholm,et al.  Characterization of adenosine receptors in isolated cerebral arteries of cat , 1983, British journal of pharmacology.

[658]  D. Hanley,et al.  Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains , 1994, Annals of neurology.

[659]  H. Drexler,et al.  Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine , 1991, The Lancet.

[660]  D. W. Cheung,et al.  Modulation of endothelium-dependent hyperpolarization and relaxation to acetylcholine in rat mesenteric artery by cytochrome P450 enzyme activity. , 1996, Circulation research.

[661]  V. Seifert,et al.  Prevention of cerebral vasospasm after experimental subarachnoid hemorrhage by RO 47-0203, a newly developed orally active endothelin receptor antagonist. , 1996, Neurosurgery.

[662]  M. Mcdaniel,et al.  Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes , 1993, Neuroscience Letters.

[663]  W. Armstead,et al.  Endothelin production links superoxide generation to altered opioid-induced pial artery vasodilation after brain injury in pigs. , 1997, Stroke.

[664]  J. Seyer,et al.  Interleukin-1 beta peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs. , 1996, The American journal of physiology.

[665]  R. Bryan,et al.  Stimulation of α2 Adrenoceptors Dilates the Rat Middle Cerebral Artery , 1996 .

[666]  S. Tokudome,et al.  Human basilar and middle cerebral arteries exhibit endothelium-dependent responses to peptides. , 1994, The American journal of physiology.

[667]  W. Mayhan Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension. , 1990, The American journal of physiology.

[668]  D. Poyner Pharmacology of receptors for calcitonin gene-related peptide and amylin. , 1995, Trends in pharmacological sciences.

[669]  S. Snyder,et al.  Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase , 1991, Nature.

[670]  S H Snyder,et al.  Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[671]  K. Uemura,et al.  Chronological changes of arterial diameter, cGMP, and protein kinase C in the development of vasospasm. , 1995, Stroke.

[672]  M. Hess,et al.  Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine. , 1990, The American journal of physiology.

[673]  G. Burnstock,et al.  Localisation of immunoreactive factor VIII, nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytryptamine in human postmortem middle cerebral artery. , 1996, Journal of anatomy.

[674]  A. Nussler,et al.  Inflammation, immunoregulation, and inducible nitric oxide synthase , 1993, Journal of leukocyte biology.

[675]  G. H. Nelson,et al.  In Vivo Effect of Methylene Blue on Endothelium‐Dependent and Endothelium‐Independent Dilations of Brain Microvessels in Mice , 1988, Circulation research.

[676]  J. Mcculloch,et al.  Contractile Responses to Endothelin in Feline Cortical Vessels in situ , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[677]  S. Moncada,et al.  Vascular endothelial cells synthesize nitric oxide from L-arginine , 1988, Nature.

[678]  J. Cooke,et al.  Arginine Restores Cholinergic Relaxation of Hypercholesterolemic Rabbit Thoracic Aorta , 1991, Circulation.

[679]  G. Ronnett,et al.  Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System , 1996, Neuron.

[680]  C. Sobey,et al.  Effect of subarachnoid hemorrhage on cerebral vasodilatation in response to activation of ATP-sensitive K+ channels in chronically hypertensive rats. , 1997, Stroke.

[681]  J. Ahlner,et al.  Organic nitrate esters: clinical use and mechanisms of actions. , 1991, Pharmacological reviews.

[682]  O. Rorstad,et al.  Cerebral Vascular Adenylate Cyclase: Evidence for Coupling to Receptors for Vasoactive Intestinal Peptide and Parathyroid Hormone , 1984, Journal of neurochemistry.

[683]  F. Faraci,et al.  Nitric Oxide and the Cerebral Circulation , 1994, Stroke.

[684]  D. Heistad,et al.  Effect of protein kinase C inhibitors on endothelin- and vasopressin-induced constriction of the rat basilar artery. , 1992, The American journal of physiology.

[685]  S. Ebrahim,et al.  Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men , 1995, The Lancet.

[686]  J. Cunningham,et al.  Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. , 1992, The Journal of biological chemistry.

[687]  A. Strosberg,et al.  Nitric oxide and endothelin secretion by brain microvessel endothelial cells: Regulation by cyclic nucleotides , 1993, Journal of cellular physiology.

[688]  X. Xu,et al.  Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism. , 1994, The American journal of physiology.

[689]  A. Takeshita,et al.  Hyperreactivity of aortic smooth muscle to serotonin is related to the presence of atheroma in Watanabe heritable hyperlipidaemic rabbits. , 1993, Cardiovascular research.

[690]  N. Standen,et al.  Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. , 1989, Science.

[691]  D. Dickson,et al.  Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. , 1993, Journal of neuroimmunology.

[692]  M. Lewis,et al.  Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. , 1993, Biochemical pharmacology.

[693]  D. Heistad,et al.  Role of ATP-sensitive potassium channels in the basilar artery. , 1993, The American journal of physiology.

[694]  R. van Furth,et al.  Levels of nitric oxide correlate with high levels of tumor necrosis factor alpha in cerebrospinal fluid samples from children with bacterial meningitis. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[695]  L. Salford,et al.  Endothelin is a potent constrictor of human intracranial arteries and veins. , 1989, Blood vessels.

[696]  L. Juillerat-Jeanneret,et al.  Involvement of a transforming‐growth‐factor‐β‐like molecule in tumor‐cell‐derived inhibition of nitric‐oxide synthesis in cerebral endothelial cells , 1995, International journal of cancer.

[697]  D. Pelligrino,et al.  NO synthase inhibition modulates NMDA-induced changes in cerebral blood flow and EEG activity. , 1996, The American journal of physiology.

[698]  R. Brandes,et al.  Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. , 1995, Atherosclerosis.

[699]  D. Heistad,et al.  Responses of cerebral arteries after ischemia and reperfusion in cats. , 1988, The American journal of physiology.

[700]  T. Kitazono,et al.  ATP-sensitive potassium channels in the basilar artery during chronic hypertension. , 1993, Hypertension.

[701]  C. Thiemermann,et al.  Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. , 1990, Biochemical and biophysical research communications.

[702]  T. Kawamoto,et al.  Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene. , 1994, European journal of biochemistry.

[703]  S. Douglas,et al.  SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[704]  D. Duverger,et al.  Elevated tissue endothelin content during focal cerebral ischemia in the rat. , 1993, Journal of cardiovascular pharmacology.

[705]  R. Roman,et al.  Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. , 1995, Journal of Vascular Research.

[706]  K. Kanamaru,et al.  Effects of nitroglycerin on vasospasm and cyclic nucleotides in a primate model of subarachnoid hemorrhage. , 1996, Stroke.

[707]  D. S. Houston,et al.  PLATELETS, ENDOTHELIUM AND VASOSPASM , 1985, Thrombosis and Haemostasis.

[708]  D. Heistad,et al.  Effects of aging on responses of cerebral arterioles. , 1990, The American journal of physiology.

[709]  M. Yanagisawa,et al.  Vasoconstrictor response of large cerebral arteries of cats to endothelin, an endothelium-derived vasoactive peptide. , 1989, European journal of pharmacology.

[710]  R. Traystman,et al.  Cerebral Blood Flow in Primates Is Increased by Isoflurane over Time and Is Decreased by Nitric Oxide Synthase Inhibition , 1994, Anesthesiology.

[711]  M. Wong,et al.  Inducible nitric oxide synthase gene expression in the brain during systemic inflammation , 1996, Nature Medicine.

[712]  S. Murphy,et al.  Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells. , 1994, Biochemical and biophysical research communications.

[713]  M. Mullan,et al.  β-Amyloid-mediated vasoactivity and vascular endothelial damage , 1996, Nature.

[714]  D. Heistad,et al.  Regulation of large cerebral arteries and cerebral microvascular pressure. , 1990, Circulation research.

[715]  M. Webb,et al.  Inhibitors of endothelin , 1997, Medicinal research reviews.

[716]  R. Floyd,et al.  Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. , 1996, Biochemical and biophysical research communications.

[717]  H. Onoue,et al.  Suppression of cerebral vasodilation with endothelin-1 , 1995, Peptides.

[718]  D. Harrison,et al.  Organization of the bovine gene encoding the endothelial nitric oxide synthase. , 1994, Biochimica et biophysica acta.

[719]  H. Shirahase,et al.  Endothelium-dependent contractions induced by angiotensin I and angiotensin II in canine cerebral artery. , 1989, The Journal of pharmacology and experimental therapeutics.

[720]  S. Sato,et al.  Increased endothelin concentration in CSF from patients with subarachnoid hemorrhage , 1990, Acta neurologica Scandinavica.

[721]  H. Esumi,et al.  Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172. , 1994, Journal of biochemistry.

[722]  A. Tomasz,et al.  Methylprednisolone attenuates inflammation, increase of brain water content and intracranial pressure, but does not influence cerebral blood flow changes in experimental pneumococcal meningitis , 1994, Brain Research.

[723]  M. Colasanti,et al.  Inhibition of inducible nitric oxide synthase mRNA expression by basic fibroblast growth factor in human microglial cells , 1995, Neuroscience Letters.

[724]  M. Nelson,et al.  Regulation of arterial tone by activation of calcium-dependent potassium channels. , 1992, Science.

[725]  T. Kitazono,et al.  Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo. , 1995, The Journal of pharmacology and experimental therapeutics.

[726]  M. Zuccarello,et al.  Prevention of subarachnoid hemorrhage-induced cerebral vasospasm by oral administration of endothelin receptor antagonists. , 1996, Journal of neurosurgery.

[727]  R. Busse,et al.  A transferable, beta‐naphthoflavone‐inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells. , 1996, The Journal of physiology.

[728]  W. Min,et al.  Functional Analysis of the Human Endothelial Nitric Oxide Synthase Promoter , 1995, The Journal of Biological Chemistry.

[729]  D. Busija Role of Prostaglandins in the Response of the Cerebral Circulation to Carbon Dioxide in Conscious Rabbits , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[730]  I. Jansen,et al.  Mechanisms of Action of the Dilatory Response to Calcitonin Gene—Related Peptide in Guinea Pig Basilary Artery , 1992 .

[731]  J. Kastelein,et al.  Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. , 1997, The Journal of clinical investigation.

[732]  R. Edwards,et al.  Calcitonin gene-related peptide stimulates adenylate cyclase and relaxes intracerebral arterioles. , 1991, The Journal of pharmacology and experimental therapeutics.

[733]  I. Wakabayashi,et al.  Impairment of Endothelium‐Dependent Relaxation in Human Basilar Artery After Subarachnoid Hemorrhage , 1992, Stroke.

[734]  R. P. Kraig,et al.  Long‐term elevation of cyclooxygenase‐2, but not lipoxygenase, in regions synaptically distant from spreading depression , 1996, The Journal of comparative neurology.

[735]  D. Heistad,et al.  Humoral Regulation of Blood Flow to Choroid Plexus: Role of Arginine Vasopressin , 1988, Circulation research.

[736]  J. Angus,et al.  Oxyhaemoglobin increases the production of endothelin-1 by endothelial cells in culture. , 1991, European journal of pharmacology.

[737]  K. Ley,et al.  Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. , 1995, Journal of immunology.

[738]  R. Cohen,et al.  The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. , 1995, Progress in cardiovascular diseases.

[739]  J. Chow,et al.  Nitric oxide synthase expression in bone cells. , 1998, Bone.

[740]  S. Archer,et al.  Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[741]  R. Koehler,et al.  Developmental and Regional Differences in Nitric Oxide Synthase Activity and Blood Flow in the Sheep Brain , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[742]  A. Kitabatake,et al.  Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. , 1996, Biochemical and biophysical research communications.

[743]  D. Heistad,et al.  Age‐Related Changes in Release of Endothelium‐Derived Relaxing Factor From the Carotid Artery , 1994, Stroke.

[744]  T. Jones,et al.  High Conductance Calcium-Activated Potassium Channels , 1995 .

[745]  C. Garland,et al.  Electrophysiology of cerebral blood vessels. , 1992, Pharmacology & therapeutics.

[746]  D. Reis,et al.  Transient expression of calcium‐independent nitric oxide synthase in blood vessels during brain development , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[747]  C Iadecola,et al.  Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. , 1994, The American journal of physiology.

[748]  G. Audibert,et al.  Effect of the Inhibitor of Nitric Oxide Synthase, NG-Nitro-L-Arginine Methyl Ester, on Cerebral and Myocardial Blood Flows During Hypoxia in the Awake Dog , 1995, Anesthesia and analgesia.

[749]  M. Nelson Ca(2+)-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone. , 1993, Trends in cardiovascular medicine.

[750]  U. Walter,et al.  NO at work , 1994, Cell.

[751]  B. Thompson,et al.  Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. , 1996, Journal of neurosurgery.

[752]  J. Brayden Hyperpolarization and relaxation of resistance arteries in response to adenosine diphosphate. Distribution and mechanism of action. , 1991, Circulation research.

[753]  P. Marsden,et al.  Cloning and characterization of murine endothelial constitutive nitric oxide synthase. , 1996, Biochimica et biophysica acta.

[754]  A. Ngai,et al.  Modulation of cerebral arteriolar diameter by intraluminal flow and pressure. , 1995, Circulation research.

[755]  T. Billiar,et al.  New insights into the regulation of inducible nitric oxide synthesis. , 1994, The American journal of physiology.

[756]  R. Roman,et al.  Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. , 1996, Stroke.

[757]  K. Frei,et al.  Experimental pneumococcal meningitis: Cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide , 1995, Annals of neurology.

[758]  G. H. Nelson,et al.  The Endothelium-Dependent Effects of Thimerosal on Mouse Pial Arterioles in vivo: Evidence for Control of Microvascular Events by EDRF as Well as Prostaglandins , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[759]  J. Mcculloch,et al.  Inhibition of Nitric Oxide Synthesis: Effects on Cerebral Blood Flow and Glucose Utilisation in the Rat , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[760]  F. Faraci,et al.  Cerebral Vasoconstrictor Responses to Serotonin During Chronic Hypertension , 1990, Hypertension.

[761]  M. Ross,et al.  Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. , 1996, Stroke.

[762]  P. Vanhoutte,et al.  ENDOTHELIUM‐DERIVED HYPERPOLARIZING FACTOR , 1996, Clinical and experimental pharmacology & physiology.

[763]  D. Heistad,et al.  Hypothesis: Vasoconstriction Contributes to Amaurosis Fugax , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[764]  T J Ebner,et al.  Nitric oxide contributes to functional hyperemia in cerebellar cortex. , 1995, The American journal of physiology.

[765]  D. Heistad,et al.  Effects of sympathetic stimulation and changes in arterial pressure on segmental resistance of cerebral vessels in rabbits and cats. , 1983, Circulation research.

[766]  H. Bada,et al.  Brain Superoxide Anion Generation in Asphyxiated Piglets and the Effect of Indomethacin at Therapeutic Dose , 1993, Pediatric Research.

[767]  G. Garcı́a-Cardeña,et al.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[768]  I. Wakabayashi,et al.  Vasorelaxant Effect of Trapidil on Human Basilar Artery , 1992, The Journal of pharmacy and pharmacology.

[769]  K. Boje Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat. , 1995, European journal of pharmacology.

[770]  R. Albrecht,et al.  Diminished muscarinic receptor-mediated cerebral blood flow response in streptozotocin-treated rats. , 1992, The American journal of physiology.

[771]  P. Penar,et al.  Role of Ca(2+)-activated K+ channels in the regulation of membrane potential and tone of smooth muscle in human pial arteries. , 1996, Circulation research.

[772]  R. Albrecht,et al.  Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat. , 1994, Neuroreport.

[773]  A Villringer,et al.  Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. , 1994, The American journal of physiology.

[774]  B. Fredholm,et al.  Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat , 1985, Neuroscience Letters.

[775]  K. Breese,et al.  Atherosclerosis potentiates constrictor responses of cerebral and ocular blood vessels to thromboxane in monkeys. , 1989, Stroke.

[776]  Drass Ja Caring for patients with insulin-dependent diabetes mellitus. , 1996 .

[777]  T. Kitazono,et al.  Relaxation of the carotid artery to hypoxia is impaired in Watanabe heritable hyperlipidemic rabbits. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[778]  T. Sundt,et al.  Release of endothelium-derived relaxing factor after subarachnoid hemorrhage. , 1989, Journal of neurosurgery.

[779]  S. Snyder,et al.  Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[780]  D. Faller,et al.  Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells , 1996 .

[781]  Y. Imaizumi,et al.  Functional role of Ca(2+)-activated K+ channels in resting state of carotid arteries from SHR. , 1993, The American journal of physiology.

[782]  M. Suzuki,et al.  Thrombin activity in cerebrospinal fluid after subarachnoid hemorrhage. , 1992, Stroke.

[783]  R. Shigemoto,et al.  Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. , 1992, Endocrinology.

[784]  J. Cooke,et al.  L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. , 1992, The Journal of clinical investigation.

[785]  F. Ashcroft,et al.  Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels , 1996, Nature.

[786]  K. Bruckdorfer,et al.  Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta , 1987, Nature.

[787]  T. J. Lee Direct evidence against acetylcholine as the dilator transmitter in the cat cerebral artery. , 1980, European journal of pharmacology.

[788]  R. Traystman,et al.  Haemophilus Influenzae Type B Impairment of Pial Vessel Autoregulation in Rats , 1993, Pediatric Research.

[789]  D. Heistad,et al.  Endothelium‐Dependent Responses of Cerebral Blood Vessels During Chronic Hypertension , 1991, Hypertension.

[790]  C. Sánchez-Ferrer,et al.  Predominant role for nitric oxide in the relaxation induced by acetylcholine in cat cerebral arteries. , 1992, The Journal of pharmacology and experimental therapeutics.

[791]  J. Javellaud,et al.  Endothelium‐dependent relaxation of rabbit middle cerebral artery to a histamine H3‐agonist is reduced by inhibitors of nitric oxide and prostacyclin synthesis , 1992, British journal of pharmacology.

[792]  J E Brayden,et al.  POTASSIUM CHANNELS IN VASCULAR SMOOTH MUSCLE , 1996, Clinical and experimental pharmacology & physiology.

[793]  A. A. Parsons,et al.  Comparison of cromakalim-induced relaxation of potassium precontracted rabbit, cat, and rat isolated cerebral arteries , 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

[794]  F. Faraci Effects of endothelin and vasopressin on cerebral blood vessels. , 1989, The American journal of physiology.

[795]  M. Runge,et al.  Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells* , 1997, The Journal of Biological Chemistry.

[796]  C. Sigmund,et al.  Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. , 1996, The Journal of clinical investigation.

[797]  T. Ohhashi,et al.  Effects of isocarbacyclin, a stable prostacyclin analogue, on monkey isolated cerebral and peripheral arteries , 1994, British journal of pharmacology.

[798]  M. Zuccarello,et al.  Endothelin‐1‐induced Endothelin‐1 Release Causes Cerebral Vasospasm In‐vivo , 1995, The Journal of pharmacy and pharmacology.

[799]  N. Toda,et al.  Different susceptibility of vasodilator nerve, endothelium and smooth muscle functions to Ca++ antagonists in cerebral arteries. , 1992, The Journal of pharmacology and experimental therapeutics.

[800]  D. Harrison,et al.  Atherosclerosis Impairs Endothelium‐Dependent Vascular Relaxation to Acetylcholine and Thrombin in Primates , 1986, Circulation research.

[801]  A. Heagerty,et al.  In vitro responses of human peripheral small arteries in hypercholesterolemia and effects of therapy. , 1995, Circulation.

[802]  I. Wakabayashi,et al.  Effect of aging on contractile response to KCl, norepinephrine and 5-hydroxytryptamine in isolated human basilar artery. , 1992, General pharmacology.

[803]  R. Bryan,et al.  Permissive role of NO in alpha 2-adrenoceptor-mediated dilations in rat cerebral arteries. , 1995, The American journal of physiology.

[804]  U. Dirnagl,et al.  Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis. , 1992, The Journal of infectious diseases.

[805]  D. Heistad,et al.  Effects of cilazapril on cerebral vasodilatation in hypertensive rats. , 1993, Hypertension.

[806]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[807]  T. Evans,et al.  Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat. , 1996, Clinical science.

[808]  G. Stansby,et al.  Homocysteine and vascular disease , 1995, The British journal of surgery.

[809]  P. Zygmunt,et al.  Effects of cytochrome P450 inhibitors on EDHF‐mediated relaxation in the rat hepatic artery , 1996, British journal of pharmacology.

[810]  M. D. Jones,et al.  Oxygen Free Radicals and the Cerebral Arteriolar Response to Group B Streptococci , 1992, Pediatric Research.

[811]  M. Moskowitz,et al.  Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. , 1996, Stroke.

[812]  S. R. Elliott,et al.  Maturation Enhances the Sensitivity of Ovine Cerebral Arteries to the ATP-Sensitive Potassium Channel Activator Lemakalim , 1994, Pediatric Research.

[813]  D. Busija,et al.  Effects of trigeminal neurotransmitters on piglet pial arterioles. , 1992, Journal of developmental physiology.

[814]  S. Snyder,et al.  Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm. , 1996, Journal of neurosurgery.

[815]  S. Dohi,et al.  Mechanisms of Vasodilation of Cerebral Vessels Induced by the Potassium Channel Opener Nicorandil in Canine In Vivo Experiments , 1994, Stroke.

[816]  M. Hart,et al.  Eicosanoid metabolism in cerebromicrovascular endothelium. , 1988, The American journal of physiology.

[817]  M. Ferrer,et al.  Comparison of the vasoconstrictor responses induced by endothelin and phorbol 12,13-dibutyrate in bovine cerebral arteries , 1992, Brain Research.

[818]  D. Heistad,et al.  Endothelium-Derived Relaxing Factor Inhibits Constrictor Responses of Large Cerebral Arteries to Serotonin , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[819]  C. Sobey,et al.  Effect of subarachnoid hemorrhage on dilatation of rat basilar artery in vivo. , 1996, The American journal of physiology.

[820]  M. Moskowitz,et al.  Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase , 1996, Neuroscience.

[821]  A. Burden,et al.  Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin-dependent diabetes mellitus. , 1994, Clinical science.

[822]  K. Frei,et al.  Production of nitrite by primary rat astrocytes in response to pneumococci , 1995, Journal of Neuroimmunology.

[823]  Y. Imaizumi,et al.  Possible involvement of ATP-sensitive K+ channels in the relaxant response of dog middle cerebral artery to cromakalim. , 1990, The Journal of pharmacology and experimental therapeutics.

[824]  H. Kontos,et al.  Nitric Oxide and S‐Nitroso‐L‐Cysteine as Endothelium‐Derived Relaxing Factors From Acetlcholine in Cerebral Vessels in Cats , 1993, Stroke.

[825]  D. Grzybicki,et al.  Modulation of inducible nitric oxide synthase expression in astroglial cells , 1994, Neuropharmacology.

[826]  Y. Ninomiya,et al.  Inhibition of vascular contraction by intracisternal administration of preproendothelin-1 mRNA antisense oligoDNA in a rat experimental vasospasm model. , 1996, Journal of neurosurgery.