Mice, men, mustard and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of human tumours to alkylating agents.

[1]  J. Murnane,et al.  The structure of methylated xanthines in relation to their effects on DNA synthesis and cell lethality in nitrogen mustard-treated cells. , 1981, Biophysical journal.

[2]  J. Murnane,et al.  Effects of methylated xanthines on mammalian cells treated with bifunctional alkylating agents , 1980, Nature.

[3]  R. Baker,et al.  HeLa cell variants that differ in sensitivity to monofunctional alkylating agents, with independence of cytotoxic and mutagenic responses. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Roberts,et al.  Excision repair of cis-diamminedichloroplatinum(II)-induced damage to DNA of Chinese hamster cells. , 1979, Cancer research.

[5]  R. Ogilvie Clinical Pharmacokinetics of Theophylline , 1978, Clinical pharmacokinetics.

[6]  R. W. Jones,et al.  The action of caffeine on X-irradiated HeLa cells. I. Delayed inhibition of DNA synthesis. , 1977, Radiation research.

[7]  J. Byfield,et al.  Molecular interactions between adriamycin and x‐ray damage in mammalian tumor cells , 1977, International journal of cancer.

[8]  U. Ehmann,et al.  Caffeine, cyclic AMP and postreplication repair of mammalian cell DNA. , 1976, Biochimica et biophysica acta.

[9]  J. Byfield,et al.  X-ray excision repair replication and radiation survival in placental mammal cells. , 1976, International journal of radiation oncology, biology, physics.

[10]  J. Mccormick,et al.  Caffeine enhancement of the cytotoxic and mutagenic effect of ultraviolet irradiation in a xeroderma pigmentosum variant strain of human cells. , 1976, Biochemical and biophysical research communications.

[11]  J. Cleaver,et al.  Metabolism of caffeine to nucleic acid precursors in mammalian cells. , 1976, Mutation research.

[12]  T. Sakaguchi,et al.  Absorption, distribution, excretion, and metabolism of 1-(5-oxohexyl) theobromine (BL 191) in rats. , 1976, Chemical & pharmaceutical bulletin.

[13]  J. Mccormick,et al.  Synergistic effect of caffeine on the cytotoxicity of ultraviolet irradiation and of hydrocarbon epoxides in strains of Xeroderma pigmentosum , 1975, Nature.

[14]  P. Todd,et al.  Potentiation by caffeine of ultraviolet-light damage in cultured human cells. , 1975, Mutation research.

[15]  J. Trosko,et al.  Excision of pyrimidine dimers from epidermal DNA and nonsemiconservative epidermal DNA synthesis following ultraviolet irradiation of mouse skin. , 1975, Cancer research.

[16]  B. Kihlman,et al.  The enhancement by caffeine of the frequencies of chromosomal aberrations induced in plant and animal cells by chemical and physical agents. , 1974, Mutation research.

[17]  B. Kihlman Effects of caffeine on the genetic material. , 1974, Mutation research.

[18]  J. Roberts,et al.  The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair. , 1974, Mutation research.

[19]  J. Roberts,et al.  Inhibition of post-replication repair of alkylated DNA by caffeine in Chinese hamster cells but not HeLa cells. , 1973, Chemico-biological interactions.

[20]  K. Sugiura,et al.  Effect of compounds on a spectrum of rat tumors. , 1972, Cancer chemotherapy reports. Part 2.

[21]  R. Painter,et al.  Evidence for DNA repair replication in unirradiated mammalian cells--is it an artifact? , 1972, Biochimica et biophysica acta.

[22]  M. Cohen Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by vitamin A and caffeine. , 1972, Journal of the National Cancer Institute.

[23]  P. Carbone,et al.  Enhancement of the antitumor effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide by vitamin A. , 1972, Journal of the National Cancer Institute.

[24]  I. Walker,et al.  Caffeine potentiation of the lethal action of alkylating agents on L-cells. , 1971, Mutation research.

[25]  J. Beavo,et al.  Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. , 1970, Molecular pharmacology.

[26]  A. Rauth,et al.  Effects of caffeine on L-cells exposed to mitomycin C. , 1970, Cancer research.

[27]  J. Kiefer,et al.  Effects of post-treatment with caffeine on the sensitivity to ultraviolet light irradiation of two lines of HeLa cells. , 1970, Mutation research.

[28]  D. Gaudin,et al.  Response of a “Resistant” Plasmacytoma to Alkylating Agents and X-Ray in Combination with the “Excision Repair Inhibitors Caffeine and Chloroquine∗ , 1969, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[29]  J. Cleaver Repair replication of mammalian cell DNA: effects of compounds that inhibit DNA synthesis or dark repair. , 1969, Radiation research.

[30]  R. Perper,et al.  Purification of lymphocytes and platelets by gradient centrifugation. , 1968, The Journal of laboratory and clinical medicine.

[31]  J. Cleaver Defective Repair Replication of DNA in Xeroderma Pigmentosum , 1968, Nature.

[32]  J. Trosko,et al.  Evidence for excision of ultraviolet-induced pyrimidine dimers from the DNA of human cells in vitro. , 1968, Biophysical journal.

[33]  A. Rauth Evidence for dark-reactivation of ultraviolet light damage in mouse L cells. , 1967, Radiation research.

[34]  P. Howard-Flanders,et al.  RELEASE OF ULTRAVIOLET LIGHT-INDUCED THYMINE DIMERS FROM DNA IN E. COLI K-12. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Setlow,et al.  THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[36]  H. Cornish,et al.  A study of the metabolism of theobromine, theophylline, and caffeine in man. , 1957, The Journal of biological chemistry.

[37]  Alfred Gilman,et al.  The Pharmacological Basis of Therapeutics , 1941, Nature.

[38]  I. Rasko,et al.  Caffeine enhancement of X-ray killing in cultured human and rodent cells. , 1978, Radiation research.

[39]  J. Roberts The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals , 1978 .

[40]  B. Kimler,et al.  The effect of caffeine on radiation-induced division delay. , 1977, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[41]  H. Lang Model for repair inhibition by caffeine , 1975 .

[42]  J. Timson Theobromine and theophylline. , 1975, Mutation research.

[43]  J. Cleaver Repair Processes for Photochemical Damage in Mammalian Cells , 1974 .

[44]  P. Tso,et al.  INTERACTION OF NUCLEIC ACIDS, I. PHYSICAL BINDING OF THYMINE, ADENINE, STEROIDS, AND AROMATIC HYDROCARBONS TO NUCLEIC ACIDS. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Gaddum The Extra Pharmacopoeia , 1937, Nature.