Intra‐operative collapse or death related to the use of acrylic cement in hip surgery

Six intra‐operative deaths and two episodes of near‐fatal hypotension occurred in 52 consecutive Hastings procedures (insertion of metal prosthesis grouted in acrylic cement) for subcapital fracture of the femoral neck. This high complication rate was identified by a system of clinical audit undertaken by members of the anaesthetic department.

[1]  J. P. Payne Letter: Ethics and halothane. , 1974, British medical journal.

[2]  D. Brown,et al.  Second-degree atrioventricular block after methyl methacrylate. , 1982, Anesthesiology.

[3]  P. Harvey,et al.  Prevention of air emboli in hip surgery , 1982, Anaesthesia.

[4]  W. Martin,et al.  Cardiovascular effects of total hip placement in man; With observations on the effects of methyl methacrylate on the isolated rabbit heart , 1977 .

[5]  G. Delespesse,et al.  Methylmethacrylate hypersensitivity in orthopaedic surgery. , 1978, Acta orthopaedica Scandinavica.

[6]  J. Alexander,et al.  Biochemical disturbances associated with total hip replacement. , 1979, The Journal of bone and joint surgery. British volume.

[7]  H. Waisbrod,et al.  Lipoprotein electrophoresis in fat embolism: a preliminary report. , 1981, Injury.

[8]  M. L. James,et al.  Blood pressure and bone cement. , 1971, British medical journal.

[9]  D. Rosborough,et al.  Fatal Fat Embolism following Replacement Arthroplasty for Transcervical Fractures of Femur , 1971 .

[10]  J. Charnley Letter: risks of total hip replacement. , 1975, British medical journal.

[11]  T. Saldeen,et al.  Arterial hypotension and hypoxaemia during total hip replacement: the importance of thromboplastic products, fat embolism and acrylic monomers. , 1976, Acta anaesthesiologica Scandinavica.

[12]  R. Gottlob,et al.  A new clinical and experimental concept on fat embolism. , 1967, The New England journal of medicine.

[13]  F. W. Blaisdell,et al.  The mechanism of pulmonary damage following traumatic shock. , 1970, Surgery, gynecology & obstetrics.

[14]  R. Phillips Phlebography in osteoarthritis of the hip. , 1966, The Journal of bone and joint surgery. British volume.

[15]  E. Salvati,et al.  The effect of total hip replacement and general surgery on antithrombin III in relation to venous thrombosis. , 1979, The Journal of bone and joint surgery. American volume.

[16]  J. Alexander Clinical considerations in anaesthesia for hip arthroplasty , 1978, Anaesthesia.

[17]  R. Wuthier,et al.  Fat macroglobulemia caused by fractures or total hip replacement. , 1978, The Journal of bone and joint surgery. American volume.

[18]  D. Dandy The safety of acrylic bone cement. , 1973, Injury.

[19]  D. Dandy Fat embolism following prosthetic replacement of the femoral head. , 1971, Injury.

[20]  B. Simpson,et al.  Cardiovascular Effects of Methylmethacrylate Cement , 1972, British medical journal.

[21]  D. Ogston,et al.  The fibrinolytic enzyme system after trauma and in patients with fat embolism. , 1974, The Journal of bone and joint surgery. British volume.

[22]  F. Stinchfield,et al.  Air embolism during total hip arthroplasties. , 1974, Anesthesiology.

[23]  W. H. Lawrence,et al.  Toxicological and pharmacological actions of methacrylate monomers. I. Effects on isolated, perfused rabbit heart. , 1973, Journal of pharmaceutical sciences.

[24]  W. Martin,et al.  Cardiovascular effects of total hip placement in man. With observations on the effects of methylmethacrylate on the isolated rabbit heart. , 1978, Clinical pharmacology and therapeutics.

[25]  A. Lettin,et al.  Cardiovascular Effects of Implanted Acrylic Bone Cement , 1971, British medical journal.

[26]  J. Sikorski,et al.  Fat and thromboembolism after total hip replacement. , 1983, Acta orthopaedica Scandinavica.

[27]  R. Michel,et al.  Air embolism in hip surgery , 1980, Anaesthesia.

[28]  T. Saldeen,et al.  Arterial Hypotension and Hypoxaemia During Total Hip Replacement: The Importance of Thromboplastic Products, Fat Embolism and Acrylic Monomers , 1975 .