An implanted system for multi-site nerve cuff-based ENG recording using velocity selectivity

This paper describes the design of an implantable system for velocity-selective electroneurogram (ENG) recording. The system, which relies on the availability of multielectrode nerve cuffs (MECs) consists of two CMOS ASICs. One ASIC called the electrode unit (EU) is a mixed analogue/digital signal acquisition system which is mounted directly on an MEC in order to optimize the interface between the two. It is linked to the other ASIC by means of a 5-core cable through which it receives power and commands in addition to transmitting data. The second ASIC, called the monitoring unit (MU) manages the interface between the EUs (each MU can control up to three EUs) and an RF transcutaneous link to the external signal processor. The ASICs are fabricated in 0.8 μm CMOS technology. The EUs measure 3 mm × 4 mm each and consume 105 mW (35 mW each), while the MU measures 1.5 mm × 2 mm and consumes 4 mW. The power consumption on the communication channels (including cable losses) between the MU and EUs is 129 mW. A digital communication strategy between the two parts of the implanted system and the external controller is described.

[1]  W. Rushton.  A theory of the effects of fibre size in medullated nerve , 1951, The Journal of physiology.

[2]  T. Stieglitz,et al.  Micromachined, Polyimide-Based Devices for Flexible Neural Interfaces , 2000 .

[3]  Murat Uzam,et al.  Design of discrete event control systems for programmable logic controllers using T-Timed Petri nets , 1996, Proceedings of Joint Conference on Control Applications Intelligent Control and Computer Aided Control System Design.

[4]  J. Hoffer,et al.  Gait phase information provided by sensory nerve activity during walking: applicability as state controller feedback for FES , 1999, IEEE Transactions on Biomedical Engineering.

[5]  Thomas Sinkjær,et al.  Cutaneous whole nerve recordings used for correction of footdrop in hemiplegic man , 1995 .

[6]  Ronald Raymond Riso,et al.  Performance of alternative amplifier configurations for tripolar nerve cuff recorded ENG , 1996, Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  Y. Perelman,et al.  An Integrated System for Multichannel Neuronal Recording with Spike / LFP Separation and Digital Output , 2005, Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005..

[8]  Rui Escadas Martins,et al.  A CMOS IC for portable EEG acquisition systems , 1998, IMTC/98 Conference Proceedings. IEEE Instrumentation and Measurement Technology Conference. Where Instrumentation is Going (Cat. No.98CH36222).

[9]  T. Sinkjaer,et al.  Control of FES thumb force using slip information obtained from the cutaneous electroneurogram in quadriplegic man. , 1999, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[10]  A. Demosthenous,et al.  Design of a low-noise preamplifier for nerve cuff electrode recording , 2003, IEEE J. Solid State Circuits.

[11]  N. Donaldson,et al.  Multiple-electrode nerve cuffs for low-velocity and velocity-selective neural recording , 2004, Medical and Biological Engineering and Computing.

[12]  W.M.C. Sansen,et al.  A micropower low-noise monolithic instrumentation amplifier for medical purposes , 1987 .

[13]  P. E. K. Donaldson,et al.  The Cooper cable: an implantable multiconductor cable for neurological prostheses , 1983, Medical and Biological Engineering and Computing.

[14]  D. Pal,et al.  Very Low-Noise ENG Amplifier System Using CMOS Technology , 2006, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[15]  Robert Rieger,et al.  10-channel very low noise ENG amplifier system using CMOS technology , 2005, 2005 IEEE International Symposium on Circuits and Systems.

[16]  M. Haugland,et al.  Artifact-free sensory nerve signals obtained from cuff electrodes during functional electrical stimulation of nearby muscles , 1994 .

[17]  R. Schmidt,et al.  Feasibility of inducing micturition through chronic stimulation of sacral roots. , 1978, Urology.

[18]  K. Wise,et al.  An implantable CMOS circuit interface for multiplexed microelectrode recording arrays , 1992 .

[19]  R. Waters,et al.  Functional electrical stimulation of the peroneal nerve for hemiplegia. Long-term clinical follow-up. , 1985, The Journal of bone and joint surgery. American volume.

[20]  Morten Kristian Haugland,et al.  Skin contact force information in sensory nerve signals recorded by implanted cuff electrodes , 1994 .

[21]  Morten Kristian Haugland,et al.  Slip information provided by nerve cuff signals: application in closed-loop control of functional electrical stimulation , 1994 .