Modulation of Gamma-Band Activity Across Local Cortical Circuits

Periodic activity patterns or oscillations within the gamma frequency band (20–80 Hz) have been implicated in sensory processing and cognition in many areas of the cerebral cortex, including primary visual cortex (V1). Although periodic activity appears to be a hallmark of cortical neurons, little is known about the dynamics of these activity patterns as signals progress within local cortical circuits. This study compares the strength of periodic activity between neurons in the input and output stages of cortical processing – neurons in layers 4 and 6 – of V1 in the alert macaque monkey. Our results demonstrate that while both populations of neurons display significant gamma-band activity, this activity increases from the input to output layers of the cortex. These data suggest that local cortical circuits enhance periodic activity within a cortical area.

[1]  W. Singer,et al.  Dynamic predictions: Oscillations and synchrony in top–down processing , 2001, Nature Reviews Neuroscience.

[2]  D Ferster,et al.  Augmenting responses evoked in area 17 of the cat by intracortical axon collaterals of cortico‐geniculate cells. , 1985, The Journal of physiology.

[3]  H. Swadlow,et al.  Corticogeniculate neurons, corticotectal neurons, and suspected interneurons in visual cortex of awake rabbits: receptive-field properties, axonal properties, and effects of EEG arousal. , 1987, Journal of neurophysiology.

[4]  Leonardo L. Gollo,et al.  Dynamical relaying can yield zero time lag neuronal synchrony despite long conduction delays , 2008, Proceedings of the National Academy of Sciences.

[5]  Farran Briggs,et al.  Temporal properties of feedforward and feedback pathways between the thalamus and visual cortex in the ferret. , 2005, Thalamus & related systems.

[6]  J Bullier,et al.  Ordinal position and afferent input of neurons in monkey striate cortex , 1980, The Journal of comparative neurology.

[7]  T. Tsumoto,et al.  Three groups of cortico‐geniculate neurons and their distribution in binocular and monocular segments of cat striate cortex , 1980, The Journal of comparative neurology.

[8]  Albert Compte,et al.  Spontaneous High-Frequency (10–80 Hz) Oscillations during Up States in the Cerebral Cortex In Vitro , 2008, The Journal of Neuroscience.

[9]  R. Desimone,et al.  Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention , 2001, Science.

[10]  G. Henry,et al.  Ordinal position of neurons in cat striate cortex. , 1979, Journal of neurophysiology.

[11]  Lawrence C. Sincich,et al.  The circuitry of V1 and V2: integration of color, form, and motion. , 2005, Annual review of neuroscience.

[12]  Alexander S. Ecker,et al.  Feature Selectivity of the Gamma-Band of the Local Field Potential in Primate Primary Visual Cortex , 2008, Front. Neurosci..

[13]  E. Callaway.  Structure and function of parallel pathways in the primate early visual system , 2005, The Journal of physiology.

[14]  Alain Destexhe,et al.  Modelling corticothalamic feedback and the gating of the thalamus by the cerebral cortex , 2000, Journal of Physiology-Paris.

[15]  Farran Briggs,et al.  A Fast, Reciprocal Pathway between the Lateral Geniculate Nucleus and Visual Cortex in the Macaque Monkey , 2007, The Journal of Neuroscience.

[16]  H. Swadlow,et al.  Efferent systems of the rabbit visual cortex: Laminar distribution of the cells of origin, axonal conduction velocities, and identification of axonal branches , 1981, The Journal of comparative neurology.

[17]  D. McCormick,et al.  Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks , 2005, Neuron.

[18]  W. Usrey,et al.  Emerging views of corticothalamic function , 2008, Current Opinion in Neurobiology.

[19]  P. Jonas,et al.  Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks , 2007, Nature Reviews Neuroscience.

[20]  W. Singer,et al.  The gamma cycle , 2007, Trends in Neurosciences.

[21]  E M Callaway,et al.  Layer-Specific Input to Distinct Cell Types in Layer 6 of Monkey Primary Visual Cortex , 2001, The Journal of Neuroscience.

[22]  D. Contreras,et al.  Cortically-induced coherence of a thalamic-generated oscillation , 1999, Neuroscience.

[23]  A. Sillito,et al.  Differential properties of cells in the feline primary visual cortex providing the corticofugal feedback to the lateral geniculate nucleus and visual claustrum , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  A. Harvey.  Characteristics of corticothalamic neurons in area 17 of the cat , 1978, Neuroscience Letters.

[25]  M. Steriade.  Impact of network activities on neuronal properties in corticothalamic systems. , 2001, Journal of neurophysiology.

[26]  C. Gray,et al.  Dynamics of striate cortical activity in the alert macaque: I. Incidence and stimulus-dependence of gamma-band neuronal oscillations. , 2000, Cerebral cortex.

[27]  A. Destexhe,et al.  Cortical Feedback Controls the Frequency and Synchrony of Oscillations in the Visual Thalamus , 2000, The Journal of Neuroscience.

[28]  T. Womelsdorf,et al.  The role of neuronal synchronization in selective attention , 2007, Current Opinion in Neurobiology.

[29]  D. J. Felleman,et al.  Distributed hierarchical processing in the primate cerebral cortex. , 1991, Cerebral cortex.