Interictal and Postictal Cognitive Changes in Migraine

The question whether symptom-free migraine patients show cognitive impairments compared to matched control subjects is addressed, and also whether migraine patients show transient cognitive impairments induced by an attack. The Neuropsychological Evaluation System (NES2) was administered once in an interictal period and twice within 30 h after different migraine attacks. Since cognitive impairments could be related to attack duration or severity, cognitive performance was compared during a postictal period after sumatriptan use and during a postictal period after habitual nonvasoactive medication use. Twenty migraineurs without aura, 10 migraineurs with aura, and 30 matched headache-free controls participated in the study. During a headache-free period, migraineurs without aura responded as quickly as controls, while migraineurs with aura were slower than controls during all tasks specifically requiring selective attention. These effects were not aggravated by a preceding migraine attack, irrespective of medication use and attack duration.

[1]  K. Ruddock,et al.  Precortical dysfunction of spatial and temporal visual processing in migraine. , 1994, Journal of neurology, neurosurgery, and psychiatry.

[2]  P. Kropp,et al.  Contingent Negative Variation During Migraine Attack and Interval: Evidence for Normalization of Slow Cortical Potentials During the Attack , 1995, Cephalalgia : an international journal of headache.

[3]  R. Evans.  Diagnostic testing for the evaluation of headaches. , 1996, Neurologic clinics.

[4]  G. Plosker,et al.  Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. , 1994, Drugs.

[5]  Giuseppe Orefice,et al.  Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study , 1988, Cephalalgia : an international journal of headache.

[6]  J. Fuster.  The Prefrontal Cortex , 1997 .

[7]  S. Kosslyn,et al.  Visual processing in migraineurs. , 1995, Brain : a journal of neurology.

[8]  J. Schoenen.  Clinical neurophysiology studies in headache: a review of data and pathophysiological hints. , 1992, Functional neurology.

[9]  K. Welch,et al.  ABNORMAL CT‐SCANS IN MIGRAINE , 1977, Headache.

[10]  C. Wink.  Beta-blockers and the central nervous system. , 1976, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[11]  G. D'andrea,et al.  Event-Related Slow Potentials and Associated Catecholamine Function in Migraine , 1990, Cephalalgia : an international journal of headache.

[12]  J. Carroll.  THE NEUROLOGICAL MANIFESTATIONS OF MIGRAINE , 1968, Headache.

[13]  S. Peroutka,et al.  Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) Nco I alleles , 1997, Neurology.

[14]  W. D. Hooker,et al.  Neuropsychologic alterations in classic and common migraine. , 1986, Archives of neurology.

[15]  M. Aickin,et al.  Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods. , 1996, American journal of public health.

[16]  J. N Blau,et al.  Migraine: theories of pathogenesis , 1992, The Lancet.

[17]  M. Oddy,et al.  Cognitive impairment in patients with severe migraine. , 1984, The British journal of clinical psychology.

[18]  E. Chronicle,et al.  Might Migraine Damage The Brain? , 1994, Cephalalgia : an international journal of headache.

[19]  H. Hannay,et al.  Neuropsychological functioning and personality characteristics of migrainous and nonmigrainous female college students. , 1989 .

[20]  F. Sakai,et al.  Regional Cerebral Hemodynamics During Migraine and Cluster Headaches Measured by the 133Xe Inhalation Method , 1978, Headache.

[21]  R. Diamond,et al.  Validation of the NES2 in patients with neurologic disorders. , 1996, Neurotoxicology and teratology.

[22]  A. Wilkins,et al.  Thresholds for Detection of a Target Against a Background Grating Suggest Visual Dysfunction in Migraine With Aura But Not Migraine Without Aura , 1995, Cephalalgia : an international journal of headache.

[23]  P. Goudswaard,et al.  Migraine Patients Cognitively Impaired? , 1990, Headache.