Spontaneous Regression of Merkel Cell Carcinoma of the Male Breast with Ongoing Immune Response

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor arising predominantly on sun-exposed skin among the elderly. The most common location is the head and neck, followed by the extremities. MCCs are highly aggressive tumors and rarely undergo spontaneous regression. We report a case of MCC which presented as a painless breast lump in an elderly male where the tumor regressed spontaneously after a biopsy.

[1]  N. Walsh Complete spontaneous regression of Merkel cell carcinoma (1986–2016): a 30 year perspective , 2016, Journal of cutaneous pathology.

[2]  K. Dresser,et al.  Complete Spontaneous Regression of Merkel Cell Carcinoma After Biopsy: A Case Report and Review of the Literature , 2016, The American Journal of dermatopathology.

[3]  F. Cirillo Spontaneous Regression of Primitive Merkel Cell Carcinoma , 2015, Rare tumors.

[4]  F. Alfageme,et al.  Spontaneous regression in merkel cell carcinoma: report of two cases with a description of dermoscopic features and review of the literature. , 2010, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  B. Smoller,et al.  New Insights Into Merkel Cell Carcinoma , 2010, Advances in anatomic pathology.

[6]  J. Becker,et al.  The etiology and epidemiology of merkel cell carcinoma. , 2010, Current problems in cancer.

[7]  A. Alzaraa,et al.  Merkel Cell Carcinoma in a Male Breast: A Case Report , 2007, The breast journal.

[8]  T. Soler,et al.  Spontaneous regression in primary cutaneous neuroendocrine (Merkel cell) carcinoma: a rare immune phenomenon? , 2002, Journal of the European Academy of Dermatology and Venereology : JEADV.

[9]  K. Kayashima,et al.  Regressing Merkel cell carcinoma—a case showing replacement of tumour cells by foamy cells , 2000, The British journal of dermatology.

[10]  C. Toker Trabecular carcinoma of the skin. , 1972, Archives of dermatology.