Alpha and beta glucocorticoid receptors: Relevance in airway diseases

[1]  R. Dubakiene,et al.  Pharmacologic and anti‐IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN) , 2006, Allergy.

[2]  J. Cidlowski,et al.  The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance , 2006 .

[3]  J. Cidlowski,et al.  Glucocorticoid receptor isoforms generate transcription specificity. , 2006, Trends in cell biology.

[4]  D. Leung,et al.  Divergent expression and function of glucocorticoid receptor β in human monocytes and T cells , 2006, Journal of leukocyte biology.

[5]  Richard J Martin,et al.  Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. , 2006, American journal of respiratory and critical care medicine.

[6]  C. Lemière,et al.  Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthma. , 2006, The Journal of allergy and clinical immunology.

[7]  I. Adcock,et al.  Update on glucocorticoid action and resistance. , 2006, The Journal of allergy and clinical immunology.

[8]  J. Cidlowski,et al.  CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor-α and Interferon-γ by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor β Isoform , 2006, Molecular Pharmacology.

[9]  J. Cidlowski,et al.  Antiinflammatory action of glucocorticoids--new mechanisms for old drugs. , 2005, The New England journal of medicine.

[10]  G. Gabay,et al.  High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance , 2005, Clinical and experimental immunology.

[11]  C. Bachert,et al.  EAACI Position Paper on Rhinosinusitis and Nasal Polyps Executive Summary , 2005, Allergy.

[12]  Q. Ouyang,et al.  Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis. , 2005, World journal of gastroenterology.

[13]  J. Mullol,et al.  Glucocorticoid receptors in human airways , 2004, Allergy.

[14]  J. Mullol,et al.  Glucocorticoid Receptor Isoforms α and β in in Vitro Cytokine-induced Glucocorticoid Insensitivity , 2004 .

[15]  J. Mullol,et al.  Expression of glucocorticoid receptors α and β in steroid sensitive and steroid insensitive interstitial lung diseases , 2004, Thorax.

[16]  Q. Hamid,et al.  Microbial Superantigens Induce Glucocorticoid Receptor β and Steroid Resistance in a Nasal Explant Model , 2004, The Laryngoscope.

[17]  W. Vedeckis,et al.  Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. , 2003, Biochemistry.

[18]  R. Ravid,et al.  Very low levels of the glucocorticoid receptor beta isoform in the human hippocampus as shown by Taqman RT-PCR and immunocytochemistry. , 2003, Brain research. Molecular brain research.

[19]  J. Cidlowski,et al.  Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta , 2003, Molecular and Cellular Biology.

[20]  J. Mullol,et al.  Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues. , 2002, American journal of physiology. Cell physiology.

[21]  Y. Kohgo,et al.  Quantitative analysis for human glucocorticoid receptor α/β mRNA in IBD , 2002 .

[22]  G. Chrousos,et al.  Increased glucocorticoid receptor Beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype. , 2002, American journal of respiratory cell and molecular biology.

[23]  J. Bousquet,et al.  Overexpression of the human glucocorticoid receptor α and β isoforms inhibits AP-1 and NF-κB activities hormone independently , 2002, Journal of Molecular Medicine.

[24]  T. Jang,et al.  Expression of Glucocorticoid Receptors and Cyclooxygenase-2 in Nasal Polyps from Nonallergic Patients , 2002, The Annals of otology, rhinology, and laryngology.

[25]  S. Muro,et al.  GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone. , 2001, The Journal of allergy and clinical immunology.

[26]  J. Cidlowski,et al.  Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  D. Phillips,et al.  Regulation of Glucocorticoid Receptor α and β Isoforms and Type I 11β-Hydroxysteroid Dehydrogenase Expression in Human Skeletal Muscle Cells: A Key Role in the Pathogenesis of Insulin Resistance? , 2001 .

[28]  G. Chrousos,et al.  Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible? , 2001, American journal of respiratory and critical care medicine.

[29]  G. Chrousos,et al.  High Constitutive Glucocorticoid Receptor β in Human Neutrophils Enables Them to Reduce Their Spontaneous Rate of Cell Death in Response to Corticosteroids , 2001, The Journal of experimental medicine.

[30]  T. Norlander,et al.  Effects of Topical Budesonide Treatment on Glucocorticoid Receptor mRNA Down-Regulation and Cytokine Patterns in Nasal Polyps , 2001, American journal of rhinology.

[31]  J. Hogg,et al.  Increased number of glucocorticoid receptor-beta-expressing cells in the airways in fatal asthma. , 2000, The Journal of allergy and clinical immunology.

[32]  J. Bousquet,et al.  Glucocorticoid Receptor α and β in Glucocorticoid Dependent Asthma , 2000 .

[33]  A. Sousa,et al.  Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform , 2000 .

[34]  T. Ashida,et al.  Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis ☆ ☆☆ , 2000 .

[35]  G. Chrousos,et al.  Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens. , 2000, The Journal of allergy and clinical immunology.

[36]  J. Cidlowski,et al.  The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. , 1999, The Journal of biological chemistry.

[37]  J. Lafitte,et al.  Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma. , 1999, American journal of respiratory and critical care medicine.

[38]  G. Chrousos,et al.  Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β , 1997, The Journal of experimental medicine.

[39]  J. Carlstedt-Duke,et al.  Evidence That the β-Isoform of the Human Glucocorticoid Receptor Does Not Act as a Physiologically Significant Repressor* , 1997, The Journal of Biological Chemistry.

[40]  G. Chrousos,et al.  Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants. , 1997, Molecular endocrinology.

[41]  Romain A. Pauwels GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , 1996 .

[42]  I. Adcock,et al.  Glucocorticoid receptor localization in normal and asthmatic lung. , 1996, American journal of respiratory and critical care medicine.

[43]  J. Cidlowski,et al.  The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. , 1996, The Journal of biological chemistry.

[44]  Kenneth J. Smith,et al.  Structural Integrity of the -Carboxyglutamic Acid Domain of Human Blood Coagulation Factor IXa Is Required for Its Binding to Cofactor VIIIa (*) , 1996, The Journal of Biological Chemistry.

[45]  P. Stierna,et al.  Regulation of glucocorticoid receptor mRNA in nasal mucosa by local administration of fluticasone and budesonide. , 1996, The Journal of allergy and clinical immunology.

[46]  G. Chrousos,et al.  Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. , 1995, The Journal of clinical investigation.

[47]  G. Chrousos,et al.  The Human Glucocorticoid Receptor (hGR) β Isoform Suppresses the Transcriptional Activity of hGRα by Interfering with Formation of Active Coactivator Complexes , 2005 .

[48]  John A Cidlowski,et al.  Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. , 2004, Proceedings of the American Thoracic Society.

[49]  J. Mullol,et al.  Expression of the glucocorticoid receptor alpha and beta isoforms in human nasal mucosa and polyp epithelial cells. , 2003, Respiratory medicine.

[50]  J. Mullol,et al.  Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone. , 2001, American journal of respiratory cell and molecular biology.

[51]  J. Koper,et al.  Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids. , 1999, Molecular and cellular endocrinology.

[52]  I. Murray,et al.  Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-kappaB: lack of effect of glucocorticoid receptor beta. , 1999, Molecular and cellular endocrinology.

[53]  E. Wouters,et al.  In vitro and in vivo modulation of alpha- and beta-glucocorticoid-receptor mRNA in human bronchial epithelium. , 1997, American journal of respiratory and critical care medicine.

[54]  J. Cidlowski,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society Expression and Subcellular Distribution of the �-Isoform , 2022 .