Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

[1]  W. Yung,et al.  An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. , 2011, Cancer cell.

[2]  Angelo J. Canty,et al.  Stem cell gene expression programs influence clinical outcome in human leukemia , 2011, Nature Medicine.

[3]  A. Jemal,et al.  Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.

[4]  Eric S. Lander,et al.  Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening , 2009, Cell.

[5]  J. Rossant,et al.  Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency , 2009, Nature Methods.

[6]  J. Dick,et al.  Stem cell concepts renew cancer research. , 2008, Blood.

[7]  P. Pandolfi,et al.  Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation , 2008, Nature Medicine.

[8]  J. Gribben,et al.  Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. , 2008, Blood.

[9]  N. Socci,et al.  High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. , 2008, Cell stem cell.

[10]  A. Regev,et al.  An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors , 2008, Nature Genetics.

[11]  Zhen-yi Wang,et al.  Acute promyelocytic leukemia: from highly fatal to highly curable. , 2008, Blood.

[12]  S. Narod,et al.  Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence , 2007, Clinical Cancer Research.

[13]  J. Buring,et al.  A Prospective Cohort Study of Cancer Incidence Following the Diagnosis of Parkinson's Disease , 2007, Cancer Epidemiology Biomarkers & Prevention.

[14]  Thomas J. Smith,et al.  2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  S. Morrison,et al.  Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells , 2006, Nature.

[16]  Megan F. Cole,et al.  Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.

[17]  Christoffer Johansen,et al.  Risk for cancer in a cohort of patients hospitalized for schizophrenia in Denmark, 1969–1993 , 2005, Schizophrenia Research.

[18]  G. Laurent,et al.  Antileukemic activity of rapamycin in acute myeloid leukemia. , 2005, Blood.

[19]  H. Kantarjian,et al.  Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. , 2004, Blood.

[20]  Y. Shinohara,et al.  Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes , 2004, Cancer Chemotherapy and Pharmacology.

[21]  Lisheng Wang,et al.  Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. , 2003, Blood.

[22]  Y. Guan,et al.  Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). , 2003, Blood.

[23]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D. Small,et al.  Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. , 2002, Blood.

[25]  J. Thomson,et al.  BMP4 initiates human embryonic stem cell differentiation to trophoblast , 2002, Nature Biotechnology.

[26]  J. Scheys,et al.  Cocaine induction of dopamine transporter trafficking to the plasma membrane. , 2002, Molecular pharmacology.

[27]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[28]  Ralf Regenthal,et al.  Drug Levels: Therapeutic and Toxic Serum/Plasma Concentrations of Common Drugs , 1999, Journal of Clinical Monitoring and Computing.

[29]  P F Thall,et al.  Randomized phase II study of fludarabine + cytosine arabinoside + idarubicin +/- all-trans retinoic acid +/- granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome. , 1999, Blood.

[30]  H. Schöler,et al.  Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 , 1998, Cell.

[31]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[32]  J. Dick,et al.  Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[33]  R. Stevens,et al.  Acute myeloid leukaemia. , 1996, British medical bulletin.

[34]  S. Ōmura,et al.  Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. , 1996, Cancer research.

[35]  E. Nestler,et al.  Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists , 1996, Science.

[36]  M. Caligiuri,et al.  A cell initiating human acute myeloid leukaemia after transplantation into SCID mice , 1994, Nature.

[37]  G. Muccioli,et al.  Steroid, Prolactin, and Dopamine Receptors in Normal and Pathologic Breast Tissue , 1986 .

[38]  P. Seeman,et al.  Neuroleptics have identical potencies in human brain limbic and putamen regions. , 1983, European journal of pharmacology.

[39]  S. Collins,et al.  Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[40]  L. Sachs.  Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia , 1978, Nature.

[41]  P. Seeman,et al.  Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. , 1975, Science.

[42]  A. Schnerch,et al.  Characterization of human embryonic stem cells with features of neoplastic progression , 2009, Nature Biotechnology.

[43]  J. Dick.  Looking ahead in cancer stem cell research , 2009, Nature Biotechnology.

[44]  D. Sibley,et al.  Molecular biology of dopamine receptors. , 1992, Trends in pharmacological sciences.

[45]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[46]  Huiping Sun,et al.  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Studies on Treatment of Acute Promyelocytic Leukemia With Arsenic Trioxide: Remission Induction, Follow-Up, and Molecular Monitoring in 11 Newly Diagnosed and 47 Relapsed Acute Promyelocytic Leukemia Patients , 2022 .