Executive functions in developmental dyslexia

The present study was aimed at investigating different aspects of Executive Functions (EF) in children with Developmental Dyslexia (DD). A neuropsychological battery tapping verbal fluency, spoonerism, attention, verbal shifting, short-term and working memory was used to assess 60 children with DD and 65 with typical reading (TR) abilities. Compared to their controls, children with DD showed deficits in several EF domains such as verbal categorical and phonological fluency, visual-spatial and auditory attention, spoonerism, verbal and visual short-term memory, and verbal working memory. Moreover, exploring predictive relationships between EF measures and reading, we found that spoonerism abilities better explained word and non-word reading deficits. Although to a lesser extent, auditory and visual-spatial attention also explained the increased percentage of variance related to reading deficit. EF deficits found in DD are interpreted as an expression of a deficient functioning of the Central Executive System and are discussed in the context of the recent temporal sampling theory.

[1]  H. Lee Swanson,et al.  Do Different Components of Working Memory Underlie Different Subgroups of Reading Disabilities? , 2006, Journal of learning disabilities.

[2]  Patrizio Emanuele Tressoldi,et al.  DDE-2,Batteria per la valutazione della dislessia e della disortografia evolutiva-2. , 2007 .

[3]  J. Fisk,et al.  Working memory functioning in developmental dyslexia , 2007, Memory.

[4]  H. Swanson,et al.  Working Memory, Short-Term Memory, and Reading Disabilities , 2009, Journal of learning disabilities.

[5]  R Hari,et al.  Auditory stream segregation in dyslexic adults. , 1999, Brain : a journal of neurology.

[6]  Mark Brosnan,et al.  Executive functioning in adults and children with developmental dyslexia , 2002, Neuropsychologia.

[7]  J. Raven Coloured progressive matrices : sets A, Ab, B , 1956 .

[8]  M. Bryden,et al.  Auditory attentional shifts in reading-disabled students: quantification of attentional effectiveness by the Attentional Shift Index , 1998, Neuropsychologia.

[9]  Jean-François Démonet,et al.  Top-down processes during auditory phoneme categorization in dyslexia: A PET study , 2007, NeuroImage.

[10]  H. Wimmer,et al.  The double-deficit hypothesis and difficulties in learning to read a regular orthography. , 2000 .

[11]  R. Tannock,et al.  Working Memory Impairments in Children with Attention-Deficit Hyperactivity Disorder With and Without Comorbid Language Learning Disorders , 2006, Journal of clinical and experimental neuropsychology.

[12]  W. Klimesch Alpha-band oscillations, attention, and controlled access to stored information , 2012, Trends in Cognitive Sciences.

[13]  K. Pammer,et al.  Attentional shifting and the role of the dorsal pathway in visual word recognition , 2006, Neuropsychologia.

[14]  T. Miles,et al.  The incidence of Stroop interference in dyslexia , 1997 .

[15]  G. Winocur,et al.  Clustering and switching on verbal fluency: the effects of focal frontal- and temporal-lobe lesions , 1998, Neuropsychologia.

[16]  A. Asbjørnsen,et al.  Executive Functions in Dyslexia , 2000, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[17]  F. Ramus,et al.  Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults. , 2003, Brain : a journal of neurology.

[18]  H. Renvall,et al.  Impaired processing of rapid stimulus sequences in dyslexia , 2001, Trends in Cognitive Sciences.

[19]  R. Engle,et al.  The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective , 2002, Psychonomic bulletin & review.

[20]  U. Goswami,et al.  Phonological representations, reading development and dyslexia: towards a cross-linguistic theoretical framework. , 2000, Dyslexia.

[21]  E. Hill Executive dysfunction in autism , 2004, Trends in Cognitive Sciences.

[22]  G. Atkinson,et al.  The physiological cost and enjoyment of Wii Fit in adolescents, young adults, and older adults. , 2010, Journal of physical activity & health.

[23]  N. Kraus,et al.  Neurobiologic responses to speech in noise in children with learning problems: deficits and strategies for improvement , 2001, Clinical Neurophysiology.

[24]  C. Cornoldi,et al.  Two New Rating Scales for Assessment of ADHD Symptoms in Italian Preschool Children , 2009, Journal of attention disorders.

[25]  G. Carlesimo,et al.  Working Memory Impairment in Children With Developmental Dyslexia: Is it Just a Phonological Deficity? , 2011, Developmental neuropsychology.

[26]  J. Pei,et al.  Executive function and memory in children with Fetal Alcohol Spectrum Disorder , 2011, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[27]  Roderick I. Nicolson,et al.  Investigating the central executive in adult dyslexics: Evidence from phonological and visuospatial working memory performance , 2003 .

[28]  Oliver Tucha,et al.  Executive functions in children with dyslexia. , 2005, Dyslexia.

[29]  Todd Richards,et al.  A Multidisciplinary Approach to Understanding Developmental Dyslexia Within Working-Memory Architecture: Genotypes, Phenotypes, Brain, and Instruction , 2008, Developmental neuropsychology.

[30]  Andrew R. A. Conway,et al.  A controlled-attention view of working-memory capacity. , 2001, Journal of experimental psychology. General.

[31]  W D Heiss,et al.  Frontal FDG-PET activity correlates with cognitive outcome after STN-DBS in Parkinson disease , 2009, Neurology.

[32]  M. D’Esposito Working memory. , 2008, Handbook of clinical neurology.

[33]  S. Gori,et al.  A Causal Link between Visual Spatial Attention and Reading Acquisition , 2012, Current Biology.

[34]  Stefano Vicari,et al.  Executive functions in intellectual disabilities: a comparison between Williams syndrome and Down syndrome. , 2013, Research in developmental disabilities.

[35]  F. Ramus,et al.  Phonological deficits in specific language impairment and developmental dyslexia: towards a multidimensional model , 2013, Brain : a journal of neurology.

[36]  Jaap Oosterlaan,et al.  How specific is a deficit of executive functioning for Attention-Deficit/Hyperactivity Disorder? , 2002, Behavioural Brain Research.

[37]  A. Facoetti,et al.  Different underlying neurocognitive deficits in developmental dyslexia: A comparative study , 2010, Neuropsychologia.

[38]  A. Miyake,et al.  Models of Working Memory: Mechanisms of Active Maintenance and Executive Control , 1999 .

[39]  A. Baddeley Is working memory still working? , 2001, The American psychologist.

[40]  Steve W Kelly,et al.  Do tasks make a difference? Accounting for heterogeneity of performance of children with reading difficulties on tasks of executive function: findings from a meta-analysis. , 2010, The British journal of developmental psychology.

[41]  L. M. Ward,et al.  Synchronous neural oscillations and cognitive processes , 2003, Trends in Cognitive Sciences.

[42]  S. Valdois,et al.  The cognitive deficits responsible for developmental dyslexia: review of evidence for a selective visual attentional disorder. , 2004, Dyslexia.

[43]  B. Pennington,et al.  Neuropsychological Analyses of Comorbidity Between Reading Disability and Attention Deficit Hyperactivity Disorder: In Search of the Common Deficit , 2005, Developmental neuropsychology.

[44]  R. Passingham Attention to action. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[45]  Karl J. Friston,et al.  Investigating a network model of word generation with positron emission tomography , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[46]  Trichur Raman Vidyasagar A neuronal model of attentional spotlight: parietal guiding the temporal , 1999, Brain Research Reviews.

[47]  B. Dritschel,et al.  Executive functions in children with Autism Spectrum Disorders , 2009, Brain and Cognition.

[48]  A. Poblano,et al.  Phonological and visuo-spatial working memory alterations in dyslexic children. , 2000, Archives of medical research.

[49]  G Jobard,et al.  Evaluation of the dual route theory of reading: a metanalysis of 35 neuroimaging studies , 2003, NeuroImage.

[50]  Nina F Dronkers,et al.  The role of inferior parietal and inferior frontal cortex in working memory. , 2006, Neuropsychology.

[51]  C. Price The anatomy of language: contributions from functional neuroimaging , 2000, Journal of anatomy.

[52]  J. Gabrieli Dyslexia: A New Synergy Between Education and Cognitive Neuroscience , 2009, Science.

[53]  A. Facoetti,et al.  The time course of attentional focusing in dyslexic and normally reading children , 2003, Brain and Cognition.

[54]  N. Birbaumer,et al.  High-frequency brain activity: Its possible role in attention, perception and language processing , 1997, Progress in Neurobiology.

[55]  U. Goswami A temporal sampling framework for developmental dyslexia , 2011, Trends in Cognitive Sciences.

[56]  P. Tallal Improving language and literacy is a matter of time , 2004, Nature Reviews Neuroscience.

[57]  C Casco,et al.  Visual Search of Good and Poor Readers: Effects with Targets Having Single and Combined Features , 1996, Perceptual and motor skills.

[58]  L. Siegel,et al.  The Double-Deficit Hypothesis , 2006, Journal of learning disabilities.

[59]  M. Saling,et al.  Do reading disabled children have planning problems , 1995 .

[60]  T. Alloway,et al.  Working memory across the lifespan: A cross-sectional approach , 2013 .

[61]  W. Marks,et al.  Specific Impairment in Developmental Reading Disabilities , 2004, Journal of learning disabilities.

[62]  Matthew W. G. Dye,et al.  Project DyAdd: Visual attention in adult dyslexia and ADHD , 2012, Brain and Cognition.

[63]  A. Baddeley,et al.  Working Memory: The multiple-component model , 1999 .

[64]  Tim Shallice,et al.  Supervisory control of action and thought selection. , 1993 .

[65]  M. Williams,et al.  Allocation of visual attention in good and poor readers , 1987, Perception & psychophysics.

[66]  Karl J. Friston,et al.  A PET study of word finding , 1991, Neuropsychologia.

[67]  F. Ramus,et al.  Developmental dyslexia : specific phonological deficit or general sensorimotor dysfunction ? , 2003 .

[68]  A. Miyake,et al.  Not All Executive Functions Are Related to Intelligence , 2006, Psychological science.

[69]  S Lehéricy,et al.  The visual word form area: spatial and temporal characterization of an initial stage of reading in normal subjects and posterior split-brain patients. , 2000, Brain : a journal of neurology.

[70]  J L Bradshaw,et al.  A Deficit in Shifting Attention Present in High-Functioning Autism but not Asperger’s Disorder , 2001, Autism : the international journal of research and practice.

[71]  M. Zafiropoulou,et al.  Drawing Performance in Prediction of Special Learning Difficulties of Kindergarten Children , 2001, Perceptual and motor skills.

[72]  Donald A. Norman,et al.  Attention to Action , 1986 .

[73]  A. Engel,et al.  Cognitive functions of gamma-band activity: memory match and utilization , 2004, Trends in Cognitive Sciences.

[74]  D P Munoz,et al.  Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). , 2009, Journal of child psychology and psychiatry, and allied disciplines.

[75]  D. Poeppel,et al.  Phase Patterns of Neuronal Responses Reliably Discriminate Speech in Human Auditory Cortex , 2007, Neuron.

[76]  C. Halldin,et al.  A PET study of , 2000, The international journal of neuropsychopharmacology.

[77]  Trichur Raman Vidyasagar From attentional gating in macaque primary visual cortex to dyslexia in humans. , 2001, Progress in brain research.

[78]  Morris J. Cohen,et al.  Memory Functioning in Children with Reading Disabilities and/or Attention Deficit/Hyperactivity Disorder: A Clinical Investigation of their Working Memory and Long-Term Memory Functioning , 2008, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[79]  E. McKone,et al.  Adults with dyslexia show deficits on spatial frequency doubling and visual attention tasks. , 2004, Dyslexia.

[80]  R. Rosenfeld Patients , 2012, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[81]  I. Nimmo-Smith,et al.  The differential assessment of children's attention: the Test of Everyday Attention for Children (TEA-Ch), normative sample and ADHD performance. , 2001, Journal of child psychology and psychiatry, and allied disciplines.

[82]  B. Pennington,et al.  Executive functions and developmental psychopathology. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[83]  John Everatt,et al.  Working memory: its role in dyslexia and other specific learning difficulties. , 2004, Dyslexia.

[84]  David M. Rocke,et al.  Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development , 2009, Psychiatry Research.

[85]  H. Renvall,et al.  Auditory Cortical Responses to Speech-Like Stimuli in Dyslexic Adults , 2002, Journal of Cognitive Neuroscience.

[86]  J. Wijers,et al.  Executive functions in children , 2014 .

[87]  W. Singer,et al.  Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties , 1989, Nature.

[88]  F. Parmentier,et al.  Visuospatial memory in dyslexia: Evidence for strategic deficits , 2013, Memory.

[89]  B. Pennington From single to multiple deficit models of developmental disorders , 2006, Cognition.

[90]  R. Abbott,et al.  Executive functions for reading and writing in typical literacy development and dyslexia , 2008, Journal of clinical and experimental neuropsychology.

[91]  John D E Gabrieli,et al.  Prediction of children's reading skills using behavioral, functional, and structural neuroimaging measures. , 2007, Behavioral neuroscience.

[92]  Turid Helland,et al.  Digit Span in Dyslexia: Variations According to Language Comprehension and Mathematics Skills , 2004, Journal of clinical and experimental neuropsychology.

[93]  Ioannis U Isaias,et al.  Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease: an ECD-SPECT study. , 2007, Parkinsonism & related disorders.

[94]  H. Swanson,et al.  Working Memory, Strategy Knowledge, and Strategy Instruction in Children With Reading Disabilities , 2010, Journal of learning disabilities.

[95]  Bruce F. Pennington,et al.  A normative‐developmental study of executive function: A window on prefrontal function in children , 1991 .

[96]  G. Wallace,et al.  Disorganization: The Forgotten Executive Dysfunction in High-Functioning Autism (HFA) Spectrum Disorders , 2005, Developmental neuropsychology.

[97]  Trichur Raman Vidyasagar,et al.  Dyslexia: a deficit in visuo-spatial attention, not in phonological processing , 2010, Trends in Cognitive Sciences.

[98]  M. Snowling,et al.  Dyslexia : A Cognitive Developmental Perspective , 1991 .

[99]  M. Turatto,et al.  Orienting of visual attention in dyslexia: evidence for asymmetric hemispheric control of attention , 2001, Experimental Brain Research.

[100]  M. Turatto,et al.  Visual-Spatial Attention in Developmental Dyslexia , 2000, Cortex.

[101]  Peter Brugger,et al.  Pervasive influence of semantics in letter and category fluency: A multidimensional approach , 2003, Brain and Language.

[102]  J. Sergeant,et al.  Proactive and reactive control of movement are differently affected in Attention Deficit Hyperactivity Disorder children. , 2013, Research in developmental disabilities.

[103]  B. Pennington,et al.  A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder. , 2001, Journal of abnormal psychology.

[104]  C. Rasmussen Executive functioning and working memory in fetal alcohol spectrum disorder. , 2005, Alcoholism, clinical and experimental research.

[105]  Robin Morris,et al.  The education of dyslexic children from childhood to young adulthood. , 2008, Annual review of psychology.

[106]  Mariano Sigman,et al.  Hierarchical Coding of Letter Strings in the Ventral Stream: Dissecting the Inner Organization of the Visual Word-Form System , 2007, Neuron.

[107]  Robert K. Heaton,et al.  Wisconsin Card Sorting Test Manual – Revised and Expanded , 1993 .