Cutaneous bleeding related to zinc deficiency in two cases of advanced cancer

One patient with metastatic squamous cell carcinoma of the larynx and one with advanced non‐Hodgkin lymphoma, both with poor nutritional status, developed ecchymoses and demonstrated prolonged bleeding time and abnormal aggregation of platelets.

[1]  B. L. O’dell,et al.  In vitro addition of glutathione to blood from zinc-deficient rats corrects platelet defects: Impaired aggregation and calcium uptake , 1997 .

[2]  H. Randriamahazaka,et al.  Influence of Zn2+ on the kinetic events that contribute to the 500-kDa dextran-sulfate-dependent activation of factor XII (Hageman factor). , 1997, European journal of biochemistry.

[3]  I. Schousboe.  Factor XIIa activation of plasminogen is enhanced by contact activating surfaces and Zn2+. , 1997, Blood Coagulation and Fibrinolysis.

[4]  G. Marx,et al.  Nutritional zinc increases platelet reactivity , 1991, American journal of hematology.

[5]  W. Kisiel,et al.  Inhibition of Recombinant Human Blood Coagulation Factor VIIa Amidolytic and Proteolytic Activity by Zinc Ions , 1991, Thrombosis and Haemostasis.

[6]  B. L. O’dell,et al.  Impaired hemostasis and platelet function in rats fed low zinc diets based on egg white protein. , 1990, The Journal of nutrition.

[7]  S. Rapaport,et al.  Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa , 1990 .

[8]  S. Rapaport,et al.  Factor VIIa-catalyzed activation of factor X independent of tissue factor: its possible significance for control of hemophilic bleeding by infused factor VIIa. , 1990, Blood.

[9]  G. Marx.  Divalent cations induce protofibril gelation , 1988, American journal of hematology.

[10]  P. Fraker,et al.  Interrelationships between zinc and immune function. , 1986, Federation proceedings.

[11]  A. Eldor,et al.  The procoagulant effect of zinc on fibrin clot formation , 1985, American journal of hematology.

[12]  B. L. O’dell,et al.  Zinc deficiency and impaired platelet aggregation in guinea pigs. , 1983, The Journal of nutrition.

[13]  A. Prasad,et al.  Anergy, zinc deficiency, and decreased nucleoside phosphorylase activity in patients with sickle cell anemia. , 1983, Annals of internal medicine.

[14]  R. Chandra,et al.  Trace Element Regulation of Immunity and Infection , 1982 .

[15]  B. L. O’dell,et al.  Effect of acute zinc deprivation on plasma zinc and platelet aggregation in adult males. , 1982, The American journal of clinical nutrition.

[16]  B. L. O’dell,et al.  Short-Term Zinc Deficiency and Hemostasis in the Rat 1 , 1980, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[17]  R. Good,et al.  Circulating thymic hormone levels in zinc deficiency. , 1979, Cellular immunology.

[18]  O. Ulutin.  Platelets : recent advances in basic research and clinical aspects : proceedings of the International Symposium on Blood Platelets, Istanbul, Turkey, August 24-27, 1974 , 1975 .

[19]  M. Stefanini.  HEMATOLOGIC ASPECTS OF PATIENTS WITH CANCER. , 1965, Progress in clinical cancer.

[20]  B. Bradford.  Nutrition and Immunity , 2012 .