Evidence for involvement of orbitofrontal cortex in memory functions: An interference effect.

Although it is frequently stated that the frontal lobes play a significant role in memory function, research proof has been ambiguous at best. This problem was addressed by administering a variety of memory tests to 16 schizophrenic patients who had undergone prefrontal leucotomy approximately 25 years earlier. The 16 were divided into three groups on the basis of recovery after surgery. Two comparison groups were established to control for psychiatric symptomatology, years of institutionalization, age, and years of education. The results demonstrate that large bilateral orbitofrontal lesions may not result in amnesia; in fact, the nonoperated schizophrenic control group performed the most poorly. Proactive interference was demonstrated, however, resulting in significant impairment for all patients with prefrontal lobe damage despite normal scores on commonly used memory tests. Ability to maintain consistent and directed attention and to overcome interference is proposed as a role of the frontal lobes in memory function.

[1]  J. Fuster.  The Prefrontal Cortex , 1997 .

[2]  E. Kaplan,et al.  Leucotomized and nonleucotomized schizophrenics: comparison on tests of attention. , 1981, Biological psychiatry.

[3]  E. Kaplan,et al.  Long-term effects of prefrontal leucotomy--an overview of neuropsychologic residuals. , 1981, Journal of clinical neuropsychology.

[4]  E. Kaplan,et al.  The long-term effects of prefrontal leukotomy. , 1981, Archives of neurology.

[5]  C Umiltà,et al.  Hemisphere‐dependent Cognitive Performances in Epileptic Patients , 1979, Epilepsia.

[6]  C. Whitty.  Amnesia. Clinical, Psychological and Medicolegal Aspects , 1978 .

[7]  M. Oscar-Berman,et al.  Stimulus-preference and memory factors in Korsakoff's syndrome , 1977, Neuropsychologia.

[8]  J M Fuster,et al.  Visual short-term memory deficit from hypothermia of frontal cortex. , 1974, Brain research.

[9]  B. Seltzer,et al.  The temporal pattern of retrograde amnesia in Korsakoff's disease , 1974, Neurology.

[10]  L. Cermak,et al.  Some comments on Warrington and Baddeley's report of normal short-term memory in amnesic patients. , 1974, Neuropsychologia.

[11]  A. Luria.  The Working Brain , 1973 .

[12]  F. Craik,et al.  Levels of processing: A framework for memory research , 1972 .

[13]  P. Lewinsohn,et al.  Short-term memory: a comparison between frontal and nonfrontal right- and left-hemisphere brain-damaged patients. , 1972, Journal of comparative and physiological psychology.

[14]  N Butters,et al.  The role of interference and encoding in the short-term memory deficits of Korsakoff patients. , 1972, Neuropsychologia.

[15]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[16]  Suzanne Corkin,et al.  Tactually-guided maze learning in man: Effects of unilateral cortical excisions and bilateral hippocampal lesions ☆ , 1965 .

[17]  M MISHKIN,et al.  Short-term memory after frontal-lobe injury in man. , 1962, Journal of comparative and physiological psychology.

[18]  K H PRIBRAM,et al.  A further experimental analysis of the behavioral deficit that follows injury to the primate frontal cortex. , 1961, Experimental neurology.

[19]  L. R. Peterson,et al.  Short-term retention of individual verbal items. , 1959, Journal of experimental psychology.

[20]  John Brown.  Some Tests of the Decay Theory of Immediate Memory , 1958 .

[21]  K. Pribram.  Some physical and pharmacological factors affecting delayed response performance of baboons following frontal lobotomy. , 1950, Journal of neurophysiology.

[22]  R. Malmo.  INTERFERENCE FACTORS IN DELAYED RESPONSE IN MONKEYS AFTER REMOVAL OF FRONTAL LOBES , 1942 .

[23]  E. Kaplan,et al.  Long-Term Effects of Prefrontal Leucotomy: Cognitive Functions , 1982 .

[24]  D. Stuss,et al.  Frontal leukotomy size and hemispheric asymmetries on computerized tomographic scans of schizophrenics with variable recovery. Northampton Veterans Administration study. , 1981, Archives of neurology.

[25]  E. Kaplan,et al.  Assessment of Cognitive Deficit in the Brain-Injured Patient , 1979 .

[26]  K. Walsh.  Neuropsychology: A Clinical Approach , 1978 .

[27]  Richard F. Thompson.  Amnesia: Clinical, psychological and medicolegal aspects. 2nd ed. , 1978 .

[28]  M. Piercy.  1 – Experimental Studies of the Organic Amnesic Syndrome , 1977 .

[29]  L Weiskrantz,et al.  A comparison of hippocampal pathology in man and other animals. , 1977, Ciba Foundation symposium.

[30]  L. Cermak,et al.  Some Analyses of Amnesic Syndromes in Brain-Damaged Patients , 1975 .

[31]  E. Kaplan,et al.  The assessment of aphasia and related disorders , 1972 .

[32]  D. Wechsler.  Manual for the Wechsler Adult Intelligence Scale. , 1955 .

[33]  D. Wechsler.  A Standardized Memory Scale for Clinical Use , 1945 .

[34]  P. Osterrieth.  Le test de copie d'une figure complexe , 1944 .

[35]  A. Rey.  Lexamen psychologique : Dans les cas d'encephalopathie traumatique (Les problemes) , 1941 .

[36]  C. Jacobsen,et al.  Studies of cerebral function in primates. IV. The effects of frontal lobe lesions on the delayed alternation habit in monkeys. , 1937 .

[37]  C. Jacobsen,et al.  Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys. , 1936 .