Vibratory stimulation increases and decreases the regional cerebral blood flow and oxidative metabolism: a positron emission tomography (PET) study

The aim of this study was to examine the hypothesis, if the activation of some cerebral structures due to physiological stimulation is accompanied by deactivations of other structures elsewhere in the brain. A vibratory stimulus was applied to the right hand palm of healthy volunteers and the regional cerebral blood flow (rCBF) and regional cerebral oxygen metabolism (rCMRO2) were measured with positron emission tomography (PET). Regional analysis and voxel‐by‐voxel plots indicated that the stimulation induced increases and decreases of the rCBF were coupled to increases and decreases of the rCMRO2. The increases were localized in the left primary somatosensory area (SI), the left secondary somatosensory area (SII), the left retroinsular field (RI), the left anterior parietal cortex, the left primary motor area (MI), and the left supplementary motor area (SMA). The decreases occurred bilaterally in the superior parietal cortex, in paralimbic association areas, and the left globus pallidus. The increases and decreases of the rCBF and rCMRO2 were balanced in such a way that the mean global CBF and CMRO2 did not change compared with rest. We conclude that the decreases of the cerebral oxidative metabolism indicated regional depressions of synaptic activity.

[1]  S. Kety,et al.  THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES. , 1948, The Journal of clinical investigation.

[2]  L. Sokoloff,et al.  The effect of mental arithmetic on cerebral circulation and metabolism. , 1955, The Journal of clinical investigation.

[3]  J. Hyvärinen,et al.  Cortical neuronal mechanisms in flutter-vibration studied in unanesthetized monkeys. Neuronal periodicity and frequency discrimination. , 1969, Journal of neurophysiology.

[4]  J. Olesen,et al.  Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intra-arterially Injected l33Xe , 1971 .

[5]  D. Ingvar,et al.  Blood flow patterns induced in the dominant hemisphere by speech and reading. , 1974, Brain : a journal of neurology.

[6]  P. Roland,et al.  Focal increase of cerebral blood flow during stereognostic testing in man. , 1976, Archives of neurology.

[7]  H. Burton,et al.  Areal differences in the laminar distribution of thalamic afferents in cortical fields of the insular, parietal and temporal regions of primates , 1976, The Journal of comparative neurology.

[8]  D. Burke,et al.  The responses of human muscle spindle endings to vibration of non‐contracting muscles. , 1976, The Journal of physiology.

[9]  D. Ingvar.  “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state , 1979, Acta neurologica Scandinavica.

[10]  H. Burton,et al.  Somatic submodality distribution within the second somatosensory (SII), 7b, retroinsular, postauditory, and granular insular cortical areas of M. fascicularis , 1980, The Journal of comparative neurology.

[11]  P. Roland,et al.  Vibratory thresholds in the hands: comparison of patients with suprathalamic lesions with normal subjects. , 1980, Archives of neurology.

[12]  P E Roland,et al.  Focal activations of human cerebral cortex during auditory discrimination. , 1981, Journal of neurophysiology.

[13]  T. Greitz,et al.  Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. , 1981, Journal of computer assisted tomography.

[14]  R. Johansson,et al.  Tactile sensory coding in the glabrous skin of the human hand , 1983, Trends in Neurosciences.

[15]  L. Sokoloff,et al.  Frequency-dependent activation of glucose utilization in the superior cervical ganglion by electrical stimulation of cervical sympathetic trunk. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[16]  B. Whitsel,et al.  Patterns of metabolic activity in cytoarchitectural area SII and surrounding cortical fields of the monkey. , 1983, Journal of neurophysiology.

[17]  R Porter,et al.  Supplementary motor area and premotor area of monkey cerebral cortex: functional organization and activities of single neurons during performance of a learned movement. , 1983, Advances in neurology.

[18]  C. Bohm,et al.  Performance Study of the PC‐384 Positron Camera System for Emission Tomography of the Brain , 1984, Journal of computer assisted tomography.

[19]  A. Crane,et al.  Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[20]  W. T. Thach,et al.  Functional mapping of the human cerebellum with positron emission tomography. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[21]  W. R. Webster,et al.  Uncrossed and crossed inhibition in the inferior colliculus of the cat: a combined 2-deoxyglucose and electrophysiological study , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[22]  M. Raichle,et al.  Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[23]  David P. Friedman,et al.  Thalamic connectivity of the second somatosensory area and neighboring somatosensory fields of the lateral sulcus of the macaque , 1986, The Journal of comparative neurology.

[24]  P E Roland,et al.  Does mental activity change the oxidative metabolism of the brain? , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  M D Ginsberg,et al.  Human task‐specific somatosensory activation , 1987, Neurology.

[26]  M. Raichle,et al.  Mapping human somatosensory cortex with positron emission tomography. , 1987, Journal of neurosurgery.

[27]  David P. Friedman,et al.  Physiological evidence for serial processing in somatosensory cortex. , 1987, Science.

[28]  M J Welch,et al.  Positron Emission Tomographic Measurement of Cerebral Blood Flow and Permeability—Surface Area Product of Water Using [15O]Water and [11C]Butanol , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[29]  M. Mintun,et al.  Nonoxidative glucose consumption during focal physiologic neural activity. , 1988, Science.

[30]  L. Haberly,et al.  Characterization of synaptically mediated fast and slow inhibitory processes in piriform cortex in an in vitro slice preparation. , 1988, Journal of neurophysiology.

[31]  Manuel F. Gonzalez,et al.  Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat , 1988, Brain Research.

[32]  T. Freund,et al.  GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus , 1988, Nature.

[33]  P. Roland,et al.  Changes in Regional Cerebral Oxidative Metabolism Induced by Tactile Learning and Recognition in Man , 1989, The European journal of neuroscience.

[34]  T Greitz,et al.  Accuracy and Precision of the Computerized Brain Atlas Programme for Localization and Quantification in Positron Emission Tomography , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  S. Stone-Elander,et al.  Motor learning in man: a positron emission tomographic study. , 1990, Neuroreport.

[36]  Christian Bohm,et al.  Somatosensory Discrimination of Shape: Tactile Exploration and Cerebral Activation , 1991, The European journal of neuroscience.

[37]  T. Greitz,et al.  A computerized brain atlas: construction, anatomical content, and some applications. , 1991, Journal of computer assisted tomography.

[38]  Karl J. Friston,et al.  Investigating a network model of word generation with positron emission tomography , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.