Configuration and conformation of a novel uridine analogue: 1H and 13C NMR spectra of (5'S)‐1‐[2'‐(2‐hydroxyethyl)tetrahydropyran‐5'‐yl]‐1H‐pyrimidine‐2,4‐dione

A combination of homo‐ and heteronuclear 1D and 2D NMR techniques provided the assignment of the 1H and 13C resonances of the major component of a reaction product consisting of the two possible diastereomers of (5′S)‐1‐[2′‐(2‐hydroxyethyl)tetrahydropyran‐5′‐yl]‐1H‐pyrimidine‐2,4‐dione and showed that the tetrahydropyranyl ring in the major 5′S,2′S‐isomer adopts the twist conformation. Copyright © 2002 John Wiley & Sons, Ltd.