Pilocytic astrocytoma of the adult--clinical features, radiological features and management

Pilocytic astrocytoma is a histological subtype of astrocytoma classically located in the cerebellum of children and young adults. Cases occurring over the age of 30 years are rare and have not been classified in terms of their clinical features and management. Suitable cases were identified using diagnostic coding and by reviewing a neuropathology database. Casenotes and neuroradiology were reviewed retrospectively. Ten cases were identified over a 6 year period with an incidence of 0.49 cases per million population per year. Tumours were equally distributed between the supra- and infra-tentorial spaces. The most common symptom was headache occurring in 90%. No patient suffered seizures. Total macroscopic treatment remains the treatment of choice. Pilocytic astrocytoma of the adult is a rare tumour with a favourable prognosis.

[1]  D. Áfra,et al.  Supratentorial lobar pilocytic astrocytomas: Report of 45 operated cases, including 9 recurrences , 2005, Acta Neurochirurgica.

[2]  T. Yoshimoto,et al.  Management of pilocytic astrocytoma , 2004, Neurosurgical Review.

[3]  H. Müller,et al.  Long-term follow-up of infratentorial pilocytic astrocytomas , 2004, Neurosurgical Review.

[4]  Y. Yonekawa,et al.  A population-based study of the incidence and survival rates in patients with pilocytic astrocytoma. , 2003, Journal of neurosurgery.

[5]  J. Parisi,et al.  Cerebellar astrocytoma: experience with 54 cases surgically treated at the Mayo Clinic, Rochester, Minnesota, from 1978 to 1990. , 1997, Journal of neurosurgery.

[6]  B. Scheithauer,et al.  Supratentorial pilocytic astrocytomas. A clinicopathologic, prognostic, and flow cytometric study of 51 patients , 1993, Cancer.

[7]  B. Scheithauer,et al.  Astrocytomas of the cerebellum: A comparative clinicopathologic study of pilocytic and diffuse astrocytomas , 1993, Cancer.

[8]  C. Raffel,et al.  Benign cerebellar astrocytomas of childhood. , 1992, Neurosurgery.

[9]  S. Canavero,et al.  Benign recurrence of a pilocytic cerebellar astrocytoma 36 years after radical removal: case report. , 1991, Neurosurgery.

[10]  G. Arrigoni,et al.  Late malignant recurrence of childhood cerebellar astrocytoma. , 1990, Clinical neuropathology.

[11]  J. Bruner,et al.  Juvenile pilocytic astrocytomas: CT and MR characteristics. , 1989, AJR. American journal of roentgenology.

[12]  J. Flickinger,et al.  Management of low‐grade gliomas of the optic nerve and chiasm , 1988, Cancer.

[13]  M. Esiri,et al.  Pituicytoma (pilocytic astrocytoma). Case report. , 1987, Journal of neurosurgery.

[14]  K. Fulling,et al.  Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. , 1985, Journal of neurosurgery.

[15]  L. Palma,et al.  Cystic pilocytic astrocytomas of the cerebral hemispheres: Surgical experience with 51 cases and long-term results , 1985 .

[16]  C. Alpers,et al.  Persistence and late malignant transformation of childhood cerebellar astrocytoma. Case report. , 1982, Journal of neurosurgery.

[17]  J. Fazekas,et al.  Treatment of grades I and II brain astrocytomas. The role of radiotherapy. , 1977, International journal of radiation oncology, biology, physics.

[18]  L. J. Rubinstein,et al.  Radiation therapy in the treatment of childhood astrocytic gliomas , 1973, Cancer.