FORMULATION AND EVALUATION OF MEDICATED JELLY OF BITTER DRUGS

Present study was aimed to formulate and evaluate medicated Jelly of Bitter drugs i.e. Ofloxacin and Ornidazole. For taste masking of Ofloxacin, ion-exchange resin method was used. The resins like Indion 204, Indion 214 and Tulsion 335 was tested at various ratios. Based on the results Tulsion 335 with the ratio 1:1.5 was selected for complexation. For taste masking of Ornidazole, addition of sweetening agent method was used. The slurry was prepared using Sorbitol 70%, Polyethylene glycol 400 and Glycerin in the concentration of 10%, 6% and 7% respectively. It was observed that the batch F7 containing 0.4% Xanthan gum, 0.5% Carrageenan and 0.3% sodium citrate and shows satisfactory results. The optimized formulation F7 evaluated which shows satisfactory results. pH of the maximum stability of Ofloxacin and Ornidazole in aqueous phase is in between 5 to 6. The drug content of jelly of batches F1 to F9 was evaluated by HPLC method. The results are between 97.00% to 103.00% for Ofloxacin and 95.00 % to 104.00 for Ornidazole. The dissolution studies of the Medicated jelly for all the formulations show more than 70% drug release at 20 minutes time point and complete drug release within 45 minutes. The optimized formulation F7 kept for the three month at storage condition and it was evaluated with similar test as per initial analysis which shows satisfactory results.