Lung cancer imaging.

Lung cancer remains the leading cause of cancer-related deaths in the US. Imaging plays an important role in the diagnosis, staging, and follow-up evaluation of patients with lung cancer. With recent advances in technology, it is important to update and standardize the radiological practices in lung cancer evaluation. In this article, the authors review the main clinical applications of different imaging modalities and the most common radiological presentations of lung cancer.

[1]  Marcos Salganicoff,et al.  Benefit of computer-aided detection analysis for the detection of subsolid and solid lung nodules on thin- and thick-section CT. , 2013, AJR. American journal of roentgenology.

[2]  Darel E. Heitkamp,et al.  ACR appropriateness criteria® hemoptysis. , 2010, Journal of thoracic imaging.

[3]  Darel E. Heitkamp,et al.  ACR Appropriateness Criteria® acute respiratory illness in immunocompetent patients. , 2011, Journal of thoracic imaging.

[4]  D. Naidich,et al.  Subsolid pulmonary nodules: imaging evaluation and strategic management , 2012, Current opinion in pulmonary medicine.

[5]  Walter J. Coulson,et al.  The rate of growth and apparent duration of untreated primary bronchial carcinoma , 1963, Cancer.

[6]  P C Goodman,et al.  Staging non-small cell lung cancer with whole-body PET. , 1999, Radiology.

[7]  E. Patz.  Imaging bronchogenic carcinoma. , 2000, Chest.

[8]  R. L. Maldonado.  The CT angiogram sign. , 1999, Radiology.

[9]  Masafumi Okada,et al.  Nuclear grading of primary pulmonary adenocarcinomas , 2010, Cancer.

[10]  Ali O. Farooqi,et al.  Lung cancer associated with cystic airspaces. , 2012, AJR. American journal of roentgenology.

[11]  A. Alavi,et al.  18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  Matthew J Hayat,et al.  Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. , 2007, The oncologist.

[13]  J. Austin,et al.  Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. , 2005, Radiology.

[14]  R. Reznek,et al.  Comparison of somatostatin analog and meta-iodobenzylguanidine radionuclides in the diagnosis and localization of advanced neuroendocrine tumors. , 2001, The Journal of clinical endocrinology and metabolism.

[15]  M. Chung,et al.  Efficacy of PET/CT in the characterization of solid or partly solid solitary pulmonary nodules. , 2008, Lung cancer.

[16]  K. Geisinger,et al.  Atypical carcinoid of the lung: radiographic features. , 1986, AJR. American journal of roentgenology.

[17]  Tae Jung Kim,et al.  Is there a role for FDG PET in the management of lung cancer manifesting predominantly as ground-glass opacity? , 2012, AJR. American journal of roentgenology.

[18]  Sumit K. Shah,et al.  Computer-aided lung nodule detection in CT: results of large-scale observer test. , 2005, Academic radiology.

[19]  B. Taal,et al.  The role of I-131-MIBG in the diagnosis and therapy of carcinoids , 2004, European Journal of Nuclear Medicine.

[20]  D. Owens,et al.  Test Performance of Positron Emission Tomography and Computed Tomography for Mediastinal Staging in Patients with NonSmall-Cell Lung Cancer , 2003, Annals of Internal Medicine.

[21]  N. Gupta,et al.  Positron emission tomography of lung tumors and mediastinal lymph nodes using [18F]fluorodeoxyglucose , 1994 .

[22]  Scott T. Grafton,et al.  PET and [18F]-FDG in oncology: a clinical update. , 1996, Nuclear medicine and biology.

[23]  K F Hübner,et al.  Differentiating benign from malignant lung lesions using "quantitative" parameters of FDG PET images. , 1996, Clinical nuclear medicine.

[24]  S. Swisher,et al.  Early-stage pulmonary adenocarcinoma (T1N0M0): a clinical, radiological, surgical, and pathological correlation of 104 cases. The MD Anderson Cancer Center Experience , 2013, Modern Pathology.

[25]  M. Kosty,et al.  Large cell/neuroendocrine carcinoma. , 2010, Lung cancer.

[26]  Huan Wang,et al.  Multilevel binomial logistic prediction model for malignant pulmonary nodules based on texture features of CT image. , 2010, European journal of radiology.

[27]  J. Gurney.  Determining the likelihood of malignancy in solitary pulmonary nodules with Bayesian analysis. Part I. Theory. , 1993, Radiology.

[28]  S. Bernstein,et al.  Solitary pulmonary nodules and masses: a meta-analysis of the diagnostic utility of alternative imaging tests , 2008, European Radiology.

[29]  C. A. Good,et al.  Calcification in solitary nodules of the lung. , 1957, The American journal of roentgenology, radium therapy, and nuclear medicine.

[30]  F. Zaccagna,et al.  Whole-tumour CT-perfusion of unresectable lung cancer for the monitoring of anti-angiogenetic chemotherapy effects. , 2013, The British journal of radiology.

[31]  S. F. Carbone,et al.  MSCT multi-criteria: a novel approach in assessment of mediastinal lymph node metastases in non-small cell lung cancer. , 2011, European journal of radiology.

[32]  Myrna C B Godoy,et al.  Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management. , 2009, Radiology.

[33]  N. Müller,et al.  Neuroendocrine carcinomas of the lung: clinical, radiologic, and pathologic correlation. , 1989, Radiology.

[34]  N. Müller,et al.  Solitary pulmonary nodule: high-resolution CT and radiologic-pathologic correlation. , 1991, Radiology.

[35]  J. Seo,et al.  Clinical utility of dual-energy CT in the evaluation of solitary pulmonary nodules: initial experience. , 2008, Radiology.

[36]  V. Roggli,et al.  Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions. , 2000, Radiographics : a review publication of the Radiological Society of North America, Inc.

[37]  D. Naidich,et al.  Subsolid pulmonary nodule management and lung adenocarcinoma classification: state of the art and future trends. , 2013, Seminars in roentgenology.

[38]  Jin Mo Goo,et al.  Predictive CT findings of malignancy in ground-glass nodules on thin-section chest CT: the effects on radiologist performance , 2008, European Radiology.

[39]  K. Miles,et al.  Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival , 2012, European Radiology.

[40]  H. Groen,et al.  Preoperative staging of non-small-cell lung cancer with positron-emission tomography. , 2000, The New England journal of medicine.

[41]  D. Yankelevitz,et al.  Peripheral carcinoid tumor of the lung: CT diagnosis. , 1990, AJR. American journal of roentgenology.

[42]  Alexander Schick,et al.  Comparison of dual-energy subtraction and electronic bone suppression combined with computer-aided detection on chest radiographs: effect on human observers' performance in nodule detection. , 2013, AJR. American journal of roentgenology.

[43]  Diagnosis of regional node metastases in lung cancer with computer-aided 3D measurement of the volume and CT-attenuation values of lymph nodes. , 2013, Academic radiology.

[44]  Richard D. White,et al.  ACR Appropriateness Criteria® acute chest pain--suspected pulmonary embolism. , 2012, Journal of thoracic imaging.

[45]  P M A van Ooijen,et al.  Inter- and intrascanner variability of pulmonary nodule volumetry on low-dose 64-row CT: an anthropomorphic phantom study. , 2013, The British journal of radiology.

[46]  D. Naidich,et al.  Overview and Strategic Management of Subsolid Pulmonary Nodules , 2012, Journal of thoracic imaging.

[47]  J R Galvin,et al.  Thoracic carcinoids: radiologic-pathologic correlation. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[48]  T. Matsumoto,et al.  A preliminary study of discrimination among the components of small pulmonary nodules by MR imaging: correlation between MR images and histologic appearance. , 2000, Radiation medicine.

[49]  O. Miettinen,et al.  CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. , 2002, AJR. American journal of roentgenology.

[50]  Y. Shim,et al.  Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. , 2007, Radiology.

[51]  F. Schick,et al.  Solitary pulmonary nodules: dynamic contrast-enhanced MR imaging--perfusion differences in malignant and benign lesions. , 2004, Radiology.

[52]  S. Matsumoto,et al.  Non-small cell lung cancer: whole-body MR examination for M-stage assessment--utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT. , 2008, Radiology.

[53]  C. White,et al.  Evaluation of the air bronchogram sign on CT in solitary pulmonary lesions. , 1996, Journal of computer assisted tomography.

[54]  E. Fishman,et al.  Pulmonary hamartoma: CT findings. , 1986, Radiology.

[55]  S S Sagel,et al.  CT of the pulmonary nodule: a cooperative study. , 1986, Radiology.

[56]  J. Herndon,et al.  T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET. , 2002, Radiology.

[57]  V. P. Collins,et al.  Differentiation of benign and malignant pulmonary nodules by growth rate. , 1962, Radiology.

[58]  J. Gurney,et al.  Determining the likelihood of malignancy in solitary pulmonary nodules with Bayesian analysis. Part II. Application. , 1993, Radiology.

[59]  W. Travis.  Lung tumours with neuroendocrine differentiation. , 2009, European journal of cancer.

[60]  Hyo Jin Kim,et al.  Solitary pulmonary nodular lung adenocarcinoma: correlation of histopathologic scoring and patient survival with imaging biomarkers. , 2012, Radiology.

[61]  C. Leidecker,et al.  Basic principles and postprocessing techniques of dual-energy CT: illustrated by selected congenital abnormalities of the thorax. , 2009, Journal of thoracic imaging.

[62]  Byung-Tae Kim,et al.  Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. , 2005, Radiology.

[63]  Alfred A Bartolucci,et al.  The accuracy of integrated PET-CT compared with dedicated PET alone for the staging of patients with nonsmall cell lung cancer. , 2004, The Annals of thoracic surgery.

[64]  Takashi Hirai,et al.  Tumor invasiveness as defined by the newly proposed IASLC/ATS/ERS classification has prognostic significance for pathologic stage IA lung adenocarcinoma and can be predicted by radiologic parameters. , 2014, The Journal of thoracic and cardiovascular surgery.

[65]  Carlo Catalano,et al.  Whole-tumor perfusion CT in patients with advanced lung adenocarcinoma treated with conventional and antiangiogenetic chemotherapy: initial experience. , 2011, Radiology.

[66]  Charles A Powell,et al.  International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. , 2011, Proceedings of the American Thoracic Society.

[67]  J. Remy,et al.  Perfusion CT allows prediction of therapy response in non-small cell lung cancer treated with conventional and anti-angiogenic chemotherapy , 2013, European Radiology.

[68]  C. Reed.  Patient versus customer, technology versus touch: where has humanism gone? , 2008, The Annals of thoracic surgery.

[69]  T. Mohammed,et al.  Assessment of the Solitary Pulmonary Nodule: An Overview , 2013 .

[70]  Hong Li,et al.  Differentiation of malignant and benign pulmonary nodules with first-pass dual-input perfusion CT , 2013, European Radiology.

[71]  H Nakata,et al.  Evolution of peripheral lung adenocarcinomas: CT findings correlated with histology and tumor doubling time. , 2000, AJR. American journal of roentgenology.

[72]  Denise R. Aberle,et al.  Radiologic implications of the 2011 classification of adenocarcinoma of the lung. , 2013, Radiology.

[73]  N. Müller,et al.  Fleischner Society: glossary of terms for thoracic imaging. , 2008, Radiology.

[74]  J. Sunderland,et al.  Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. , 1992, Radiology.

[75]  H. Libshitz,et al.  Roentgenographic evaluation of mediastinal nodes for preoperative assessment in lung cancer. , 1985, Chest.

[76]  E. Gunel,et al.  Probability of malignancy in solitary pulmonary nodules using fluorine-18-FDG and PET. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[77]  G. V. von Schulthess,et al.  Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. , 2003, The New England journal of medicine.

[78]  G. Gladish,et al.  Imaging of non-small cell lung cancer of the superior sulcus: part 2: initial staging and assessment of resectability and therapeutic response. , 2008, Radiographics : a review publication of the Radiological Society of North America, Inc.

[79]  Jue Zhang,et al.  Comparison of MRS and DWI in the diagnosis of prostate cancer based on sextant analysis , 2013, Journal of magnetic resonance imaging : JMRI.

[80]  Gilles Chatellier,et al.  Software volumetric evaluation of doubling times for differentiating benign versus malignant pulmonary nodules. , 2006, AJR. American journal of roentgenology.

[81]  L. Luo,et al.  Differentiation of Central Lung Cancer from Atelectasis: Comparison of Diffusion-Weighted MRI with PET/CT , 2013, PloS one.

[82]  Jinming Yu,et al.  Value of PET/CT versus enhanced CT for locoregional lymph nodes in non-small cell lung cancer. , 2008, Lung cancer.

[83]  C. White,et al.  Imaging characteristics of lung cancer. , 2011, Seminars in roentgenology.

[84]  D K Owens,et al.  Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. , 2001, JAMA.

[85]  S. Matsumoto,et al.  Prognostic value of dynamic MR imaging for non‐small‐cell lung cancer patients after chemoradiotherapy , 2005, Journal of magnetic resonance imaging : JMRI.

[86]  J. Remy,et al.  Lung perfusion with dual-energy multi-detector row CT: can it help recognize ground glass opacities of vascular origin? , 2010, Academic radiology.

[87]  C. Moran,et al.  Bronchogenic carcinoma: radiologic-pathologic correlation. , 1994, Radiographics : a review publication of the Radiological Society of North America, Inc.

[88]  Wei-Chih Shen,et al.  Density features of screened lung tumors in low-dose computed tomography. , 2014, Academic radiology.

[89]  Roberto Maroldi,et al.  Texture analysis of advanced non-small cell lung cancer (NSCLC) on contrast-enhanced computed tomography: prediction of the response to the first-line chemotherapy , 2013, European Radiology.

[90]  Lorraine Wilson,et al.  Lymph node staging by means of positron emission tomography is less accurate in non-small cell lung cancer patients with enlarged lymph nodes: analysis of 1,145 lymph nodes. , 2008, Lung cancer.

[91]  V Kalff,et al.  F‐18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with nonsmall cell lung carcinoma , 2001, Cancer.