论文信息 - Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent

Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent

Abstract A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure–activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies. GRAPHICAL ABSTRACT

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