The interplay of dendritic cell subsets in systemic lupus erythematosus

Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN‐α produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis.

[1]  Michel C. Nussenzweig,et al.  Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[2]  L. Rönnblom,et al.  A Pivotal Role for the Natural Interferon α–producing Cells (Plasmacytoid Dendritic Cells) in the Pathogenesis of Lupus , 2001, The Journal of experimental medicine.

[3]  Antonio Lanzavecchia,et al.  BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction , 2001, The Journal of experimental medicine.

[4]  L. Rönnblom,et al.  A Pivotal Role for the Natural Interferon α–producing Cells (Plasmacytoid Dendritic Cells) in the Pathogenesis of Lupus , 2001 .

[5]  Virginia Pascual,et al.  Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus , 2001, Science.

[6]  G. Peltz,et al.  Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. , 2001, Immunity.

[7]  T. Behrens,et al.  Delineating the genetic basis of systemic lupus erythematosus. , 2001, Immunity.

[8]  V. Pascual,et al.  Increased Frequency of Pre-germinal Center B Cells and Plasma Cell Precursors in the Blood of Children with Systemic Lupus Erythematosus1 , 2001, The Journal of Immunology.

[9]  F. Belardelli,et al.  Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. , 2001, Immunity.

[10]  A. Bakker,et al.  Id2 and Id3 Inhibit Development of Cd34+ Stem Cells into Predendritic Cell (Pre-Dc)2 but Not into Pre-Dc1 , 2000, The Journal of experimental medicine.

[11]  B. Blom,et al.  Generation of Interferon α–Producing Predendritic Cell (Pre-Dc)2 from Human Cd34+ Hematopoietic Stem Cells , 2000, The Journal of experimental medicine.

[12]  P. Lipsky,et al.  Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus1 , 2000, The Journal of Immunology.

[13]  N. Kadowaki,et al.  Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity , 2000, The Journal of experimental medicine.

[14]  D. Isenberg,et al.  Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy. , 2000, Arthritis and rheumatism.

[15]  J. Banchereau,et al.  Flt3-Ligand and Granulocyte Colony-Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets In Vivo1 , 2000, The Journal of Immunology.

[16]  T. Di Pucchio,et al.  Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice , 2000, The Journal of experimental medicine.

[17]  D. Isenberg.  Lupus—molecular and cellular pathogenesis. , 2000, Annals of the rheumatic diseases.

[18]  F. Huang,et al.  A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes , 2000, The Journal of experimental medicine.

[19]  R. Steinman,et al.  The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells , 2000, The Journal of experimental medicine.

[20]  L. Rönnblom,et al.  Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus. , 1999, Journal of immunology.

[21]  D. Jarrossay,et al.  Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon , 1999, Nature Medicine.

[22]  N. Kadowaki,et al.  The nature of the principal type 1 interferon-producing cells in human blood. , 1999, Science.

[23]  M. Cooper,et al.  Impairment of  T and B Cell Development by Treatment with a Type I Interferon , 1998, The Journal of experimental medicine.

[24]  J. Banchereau,et al.  CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha: II. Functional analysis. , 1997, Blood.

[25]  J. Banchereau,et al.  The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand , 1997, The Journal of experimental medicine.

[26]  R. Zinkernagel,et al.  Virus-induced Transient Bone Marrow Aplasia: Major Role of Interferon-α/β during Acute Infection with the Noncytopathic Lymphocytic Choriomeningitis Virus , 1997, The Journal of experimental medicine.

[27]  F. Finkelman,et al.  Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. , 1996, Journal of immunology.

[28]  J. Banchereau,et al.  CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype , 1996, The Journal of experimental medicine.

[29]  R. Steinman,et al.  Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. , 1994, Immunology.

[30]  E. Schrumpf,et al.  Psoriasis induced by interferon‐α , 1991 .

[31]  C. Steinman,et al.  Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone. , 1990, The Journal of clinical investigation.

[32]  D. Woodrow,et al.  Interferon-induced glomerular basement membrane and endothelial cell lesions in mice. An immunogold ultrastructural study of basement membrane components. , 1988, The American journal of pathology.

[33]  A. Meager,et al.  IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS , 1987, The Lancet.

[34]  R. Friedman,et al.  Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon. , 1982, Science.

[35]  I. Gresser,et al.  Progressive glomerulonephritis in mice treated with interferon preparations at birth , 1976, Nature.

[36]  K. Lennert,et al.  T-ASSOCIATED PLASMA-CELLS , 1975, The Lancet.

[37]  S. Imamura,et al.  CD 34 + Hematopoietic Progenitors from Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to GM-CSF + TNFoL , 2003 .

[38]  R. Steinman.  Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance , 2002 .

[39]  W. Heath,et al.  Cross-presentation, dendritic cells, tolerance and immunity. , 2001, Annual review of immunology.

[40]  R. Williams,et al.  Detection of nucleosome particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7. , 2001, The Journal of rheumatology.

[41]  V. Pascual,et al.  Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. , 2001, Science.

[42]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[43]  E. Schrumpf,et al.  Psoriasis induced by interferon-alpha. , 1991, The British journal of dermatology.

[44]  K. Lennert,et al.  [Pseudofollicular nests of plasmacells (of a special type?) in paracortical pulp of human lymph nodes (author' s transl)]. , 1973, Virchows Archiv. B, Cell pathology.