Tandem driven dynamic self-inhibition of acetylcholinesterase.

A concept of tandem driven dynamic self-inhibition is demonstrated through dynamic inhibitors of acetylcholinesterase (AChE) using reversible transthiolesterification.

[1]  O. Ramström,et al.  Dynamic asymmetric multicomponent resolution: lipase-mediated amidation of a double dynamic covalent system. , 2009, Journal of the American Chemical Society.

[2]  Fei Wang,et al.  Study on acetylcholinesterase inhibition induced by endogenous neurotoxin with an enzyme-semiconductor photoelectrochemical system. , 2009, Chemical communications.

[3]  A. Fischer,et al.  Crystallization-induced secondary selection from a tandem driven dynamic combinatorial resolution process. , 2008, The Journal of organic chemistry.

[4]  A. Fischer,et al.  Tandem driven dynamic combinatorial resolution via Henry-iminolactone rearrangement. , 2008, Chemical communications.

[5]  D. Trauner,et al.  Regulating Enzymatic Activity with a Photoswitchable Affinity Label , 2008, Chembiochem : a European journal of chemical biology.

[6]  Jean-Marie Lehn,et al.  From supramolecular chemistry towards constitutional dynamic chemistry and adaptive chemistry. , 2007, Chemical Society reviews.

[7]  R. Larsson,et al.  Dynamic combinatorial resolution: direct asymmetric lipase-mediated screening of a dynamic nitroaldol library. , 2007, Angewandte Chemie.

[8]  S. Gellman,et al.  An antiparallel alpha-helical coiled-coil model system for rapid assessment of side-chain recognition at the hydrophobic interface. , 2006, Journal of the American Chemical Society.

[9]  P. Corbett,et al.  Dynamic combinatorial chemistry. , 2006, Chemical reviews.

[10]  Bas de Bruin,et al.  Dynamic combinatorial chemistry: the unexpected choice of receptors by guest molecules. , 2006, Angewandte Chemie.

[11]  William Lindstrom,et al.  Inhibitors of HIV-1 protease by using in situ click chemistry. , 2006, Angewandte Chemie.

[12]  M. K. Azim,et al.  Structural basis of acetylcholinesterase inhibition by triterpenoidal alkaloids. , 2005, Biochemical and biophysical research communications.

[13]  J. Sanders,et al.  Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages. , 2005, Chemical communications.

[14]  D. Reinhoudt,et al.  Templation in Noncovalent Synthesis of Hydrogen-Bonded Rosettes , 2005 .

[15]  S. Gellman,et al.  Backbone thioester exchange: a new approach to evaluating higher order structural stability in polypeptides. , 2004, Journal of the American Chemical Society.

[16]  R. Larsson,et al.  Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library. , 2004, Angewandte Chemie.

[17]  Chi-Huey Wong,et al.  In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. , 2004, Angewandte Chemie.

[18]  Yuan-Ping Pang,et al.  Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. , 2003, Journal of the American Chemical Society.

[19]  P. Taylor,et al.  Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. , 2002, Angewandte Chemie.

[20]  Olof Ramström,et al.  Drug discovery by dynamic combinatorial libraries , 2002, Nature Reviews Drug Discovery.

[21]  J. Lehn,et al.  Dynamic Deconvolution of a Pre‐Equilibrated Dynamic Combinatorial Library of Acetylcholinesterase Inhibitors , 2001, Chembiochem : a European journal of chemical biology.

[22]  C. Guillou,et al.  Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts. , 2000, Bioorganic & medicinal chemistry letters.

[23]  P Taylor,et al.  The cholinesterases: from genes to proteins. , 1994, Annual review of pharmacology and toxicology.

[24]  J. Sussman,et al.  Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[25]  D. Rideout,et al.  A self-assembling protein kinase C inhibitor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26]  S. Bernhard,et al.  Studies of catalysis by acetylcholinesterase. Synergistic effects of inhibitors during the hydrolysis of acetic acid esters. , 1972, Biochemistry.

[27]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.