Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors

Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms and the pathophysiological significance of this high glucose need remain unclear. While the role for hypoxia and hypoxia inducible factor 1α has been demonstrated, the contribution of lipid micro‐environment and more specifically oxysterols is yet to be explored.

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